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Human FURIN Protein expressed in HEK-293 Cells - ABIN2181123
Roveri, Pfohl, Jaaks, Alijaj, Leroux, Luciani, Bernasconi: Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma. in Nanomedicine (London, England) 2017
Human FURIN Protein expressed in Wheat germ - ABIN1354517
Heng, Dynon, Li, Edgell, Walton, Rombauts, Vollenhoven, Nie: Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. in Analytical biochemistry 2015
Silencing furin genes reduced the survival of M. marinum-infected zebrafish embryos. A mycobacterial infection upregulated furinA in adult zebrafish.
Genetic analysis of fin development in zebrafish identifies furin as potential novel fraser syndrome disease genes
furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning
2 out of 3 schizophrenia (SCZ)-associated SNPs located in the 3'UTR were predicted to alter 3 miRNAs' binding sites in 2 target genes. Of the identified SNPs, the most genome-wide significant SNP rs4702 (A/G) in the FURIN 3'UTR. Allele-specific downregulation of FURIN by miR-338-3p was validated; also demonstrated that miR-338-3p-mediated FURIN inhibition reduced BDNF maturation and secretion.
It has been shown that the cytoplasmic domains of furin bind the mu subunits of AP-1 and AP-2 in a phosphorylation-dependent manner.
High FURIN levels show signs of lower disease activity suggesting that FURIN might have a protective role in primary Sjogren's syndrome.
the furin inhibitor dec-RVKR-CMK blocked entry of MERS-CoV harboring an S protein lacking furin cleavage sites; it even blocked entry into furin-deficient LoVo cells. In addition, dec-RVKR-CMK inhibited not only the enzymatic activity of furin but also those of cathepsin L, cathepsin B, trypsin, papain, and TMPRSS2.
Using protein X-ray crystallography, this study investigated the extended substrate binding site of furin in complex with three peptide-derived inhibitors at up to 1.9 A resolution.
In squamous cell carcinoma of the cervix (SCCC), higher levels of MMP-14 expression were established in tumor cells, as evidenced by IHC (+3) and RT-PCR.Furin activity in the tumor was much higher than that in normal tissues. The expression of TIMP-2 mRNA was sufficiently obvious in both the tumor and normal tissues to the bottom of the uterine cavity.
these findings identify furin as an important factor for aRMS progression and survival. Thus, we propose furin as a novel therapeutic target for treatment of aRMS.
Novel protein crystallographic structures of the prototypical PC family member furin in different functional states were determined to 1.8-2.0 A.
findings uncover a role of ERK1 in the regulation of furin activity by supporting a self-sustaining loop for high TGF-beta activity in glioma-initiating cells.
Divers studies have confirmed the expression of furin in a large spectrum of cancers. Functional studies modulating its activity uncovered its importance for the processing of many cancer-related substrates and strongly indicate that high furin activity promotes the malignant phenotype of cancer cells. [review]
Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells probably via Hippo-YAP pathway and may be a potential target for anti-pancreatic cancer.
Results suggest that (pro)renin receptor (s(P)RR) is generated by sequential processing by site-1 protease (S1P) and furin protein.
Compared with the homozygous genotype CC of rs2071410, the frequency of CG + GG genotype in the case group was significantly higher than in the control group. Individuals with CG + GG genotype had 49.3% increased risk of Transient Ischemic Attack compared with individuals with CC genotype. Patients with CG + GG genotype had worse 90-day prognosis after Transient Ischemic Attack treatment than patients with CC genotype.
our study provides evidence that furin activity and epithelial-mesenchymal transition are potential indicators of the aggressive phenotype in recurrent laryngeal cancer after irradiation and that furin is a potentially useful target against laryngeal cancer
Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
The authors show that Human papillomavirus type 16 L2 is cleaved during virion morphogenesis in differentiated tissue and that tissue-derived native virus initiates infection independent of cellular furin.
Data suggest that the full Crimean-Congo hemorrhagic fever virus can be reproduced by reverse genetics; in this system, furin cleavage of the nonstructural glycoprotein reveals mature GP38.
we could not confirm an effect of the SNP on FURIN expression in vitro and no correlations could be found in vivo with FURIN expression or outcome.
the plasma level of FURIN does not predict the severity of infectious disease, it may be of use in the diagnostics of autoimmune diseases.
Upon meiosis onset, active furin/IGF-1 receptor relocates into the cytoplasm to activate (phosphorylate) Akt to promote meiosis. In summary, our finding suggests that Plac1, a protein that is crucial for placentation, is also essential for oocyte meiosis and fertilization.
The developmental arrest of early secondary follicles following furin disruption might be rooted in the loss of the mature form of ADAMTS1 and compromised proliferation of granulosa cells in mutant mice.
FURIN has an anti-inflammatory function in LysM+ myeloid cells in vivo.
The proprotein convertase furin is responsible for pro-OCN maturation in vitro and in vivo.
Studied the impact of Furin inhibition on the development and progression of hepatocellular carcinoma.
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation
the role of serpinB8/furin in obesity-associated chronic inflammation
Furin has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase in hepatocytes
overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
we observed an increased susceptibility to UV in single furin transgenic mice that was not substantially enhanced in the double furin/PACE4 transgenic mice.
These data suggest that obesity states facilitate the cleavage of adipolin presumably through upregulation of furin in adipose tissue.
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.
An endothelial cell-specific knockout mice of the Furin gene was generated. This resulted in postnatal lethality, likely due to heart ventricular septal and/or valve defects.
Furin and Pace4 are released by the extraembryonic microenvironment, and that they cleave a membrane-bound reporter substrate in adjacent epiblast cells and activate Nodal to maintain pluripotency
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.
in hepatocytes furin regulates PCSK9 mRNA levels and is the key in vivo-inactivating protease of circulating PCSK9.
transferrin receptor 2 and HFE are involved in holotransferrin-dependent signaling for the regulation of furin which involved Erk phosphorylation. Furin in turn may control hepcidin expression.
Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase
Point mutation of the furin cleavage site at the S2' position of the S protein enables the virus to infect cultured cells independently of trypsin.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene.
furin (paired basic amino acid cleaving enzyme)
, furin A
, furin B
, FES upstream region
, dibasic processing enzyme
, dibasic-processing enzyme
, furin, membrane associated receptor protein
, paired basic amino acid residue-cleaving enzyme
, proprotein convertase subtilisin/kexin type 3
, paired basic amino acid residue cleaving enzyme
, prohormone convertase 3
, subtilisin pro-protein processing enzyme
, paired basic amino acid cleaving enzyme
, trans Golgi network protease furin
, Paired basic amino acid cleaving enzyme (furin)
, Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
, proprotein convertase subtilisin/kexin type3