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Missense p.V742G variant in MIB2 is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.
Here, we report a novel interaction between CYLD and MIB2 that supports the hypothesis that the CYLD/MIB2 interaction might play a pathogenic role in human cancer.
The DLAIS motif in MAVS (show MAVS Proteins) was found to be critical for MIB2 binding, the ligation of K63-linked ubiquitin to TANK-binding kinase 1 (show TBK1 Proteins), and phosphorylation-mediated IRF3 (show IRF3 Proteins)/7 activation.
identify MIB2 as a novel component of the activated BCL10 (show BCL10 Proteins) signaling complex and a missing link in the BCL10 (show BCL10 Proteins)-dependent NF-kappaB (show NFKB1 Proteins) signaling pathway.
Mib2 has functional similarities to Mib1, but might have distinct roles in Notch (show NOTCH1 Proteins) signaling as an E3 ubiquitin ligase (show MUL1 Proteins)
Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is down-regulated in melanoma.
skeletrophin is a novel ubiquitin ligase that targets the intracellular region of Jagged-2 (show JAG2 Proteins) and is aberrantly overexpressed in multiple myeloma cells.
skeletrophin might be a novel suppressor factor for melanoma invasion
Data identify Mind bomb-2 as an E3 ubiquitin ligase (show MUL1 Proteins) that interacts with and ubiquitinates the NR2B (show GRIN2B Proteins) subunit of the NMDAR (show GRIN1 Proteins) in mammalian cells.
created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube
Mib and Mib2 interact with Fih-1 that is involved in the hypoxia signaling pathway.
Zebrafish Mib and Mib2 are colocalized in transfected cells and function redundantly in regulating Notch (show NOTCH1 Proteins) signaling in embryos.
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
E3 ubiquitin-protein ligase MIB2
, mind bomb homolog 2
, mindbomb homolog 2
, novel zinc finger protein
, putative NF-kappa-B-activating protein 002N
, zinc finger ZZ type with ankyrin repeat domain protein 1
, zinc finger, ZZ type with ankyrin repeat domain 1
, dystrophin-like protein
, mind bomb-2
, RBSC-skeletrophin/dystrophin-like polypeptide
, mindbomb E3 ubiquitin protein ligase 2 S homeolog