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Missense p.V742G variant in MIB2 is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.
Here, we report a novel interaction between CYLD and MIB2 that supports the hypothesis that the CYLD/MIB2 interaction might play a pathogenic role in human cancer.
The DLAIS motif in MAVS was found to be critical for MIB2 binding, the ligation of K63-linked ubiquitin to TANK-binding kinase 1, and phosphorylation-mediated IRF3/7 activation.
identify MIB2 as a novel component of the activated BCL10 signaling complex and a missing link in the BCL10-dependent NF-kappaB signaling pathway.
Mib2 has functional similarities to Mib1, but might have distinct roles in Notch signaling as an E3 ubiquitin ligase
Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is down-regulated in melanoma.
skeletrophin is a novel ubiquitin ligase that targets the intracellular region of Jagged-2 and is aberrantly overexpressed in multiple myeloma cells.
skeletrophin might be a novel suppressor factor for melanoma invasion
Data identify Mind bomb-2 as an E3 ubiquitin ligase that interacts with and ubiquitinates the NR2B subunit of the NMDAR in mammalian cells.
created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube
Mib and Mib2 interact with Fih-1 that is involved in the hypoxia signaling pathway.
Zebrafish Mib and Mib2 are colocalized in transfected cells and function redundantly in regulating Notch signaling in embryos.
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
E3 ubiquitin-protein ligase MIB2
, mind bomb homolog 2
, mindbomb homolog 2
, novel zinc finger protein
, putative NF-kappa-B-activating protein 002N
, zinc finger ZZ type with ankyrin repeat domain protein 1
, zinc finger, ZZ type with ankyrin repeat domain 1
, dystrophin-like protein
, mind bomb-2
, RBSC-skeletrophin/dystrophin-like polypeptide
, mindbomb E3 ubiquitin protein ligase 2 S homeolog