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These findings support the therapeutic application of resveratrol and ERR-alpha in combating obesity-mediated cardiac dysfunction.
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results reveal a novel ERRalpha/RANK axis by which ERRalpha in primary breast cancer promotes early dissemination of cancer cells to bone. These findings suggest that ERRalpha may be a useful therapeutic target to prevent bone metastases.
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this study identifies ESRRA as a critical activator of autophagy via both transcriptional and posttranslational control to promote antimicrobial host responses.
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Systemic ablation of ERRalpha in mice demonstrated clear beneficial effects for loss of ERRalpha function in protection from HFD-provoked body weight gain manifested not only from a reduction in white adipose tissue stores but also from an impediment in intrahepatic lipid accumulation. The prevention of HFD-induced NAFLD in ERRalpha-null mice was underscored by transcriptional repression of de novo lipogenesis.
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ERRalpha overexpression attenuated Tau phosphorylation at selective sites in an animal model of Alzheimer's disease.
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This work reveals a molecular mechanism by which ERRalpha-induced metabolic reprogramming promotes survival of lapatinib-resistant cancer cells.
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the involvement of ERRalpha in the progression of cisplatin-induced AKI is probably through impaired mitochondrial dynamics
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Localizing ESRRA binding sites in cortical chromatin, it has been shown that this nuclear receptor binds both differentially expressed energy-related and neurodevelopmental transcription factor genes during social challenge.
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The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells
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findings highlight a MYC/ERRalpha pathway that contributes to physiological and pathological bone loss by integrating the MYC/ERRalpha axis to drive metabolic reprogramming during osteoclast differentiation
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Study performed a structural and functional assessment of glutamatergic synapses on medium spiny neurons in the nucleus accumbens of Esrra-null mice, and discovered sex-specific alterations in miniature excitatory postsynaptic currents frequency and amplitude, reduced paired-pulse ratio, and reduction in glutamatergic synaptic vesicles consistent with altered functional connectivity
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The nuclear receptor, estrogen-related receptor alpha (ERRalpha), was shown to regulate the expression of genes required for lactate utilization.
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In bone, the effects of cholesterol, statin, and bisphosphonate on osteoclastogenesis require ERRalpha; and consequently, cholesterol-induced bone loss or bisphosphonate osteoprotection is lost in ERRalpha knockout mice.
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We conclude that E2-induced ERRalpha expression in endothelium plays an important role for the E2-induced vasculoprotective effect
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Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
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These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.
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Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor activation in aged male mice.
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ERRa is a negative regulator of TLR-induced inflammatory responses through inducing Tnfaip3 transcription and controlling the metabolic reprogramming.
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study shows that ERRalpha plays a key role in directing transcriptional programs required for optimal mitochondrial oxidative potential and muscle fitness
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Mice lacking both ERRalpha and cardiac Errg develop severe bradycardia, lethal cardiomyopathy, and heart failure featuring metabolic, contractile, and conduction dysfunctions.
