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maintenance of the cancer cell state is dependent on recruitment of Mediator and Cohesin through FOXA and master transcription factors
co-expression of PPARgamma (show PPARG Antibodies) and TRAP220 represents a biomarker for good prognosis in colorectal cancer patients
Data suggest that mediator complex subunit 1 (Med1/TRAP220) is a target for checkpoint kinase 2 (Chk2 (show CHEK2 Antibodies))-mediated phosphorylation and may play a role in cellular DNA damage responses by mediating proper induction of gene transcription upon DNA damage.
In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR (show NR3C1 Antibodies)) pathway with the genes MED1, HSPA1L (show HSPA1L Antibodies), GTF2A1 (show GTF2A1 Antibodies) and TAF15 (show TAF15 Antibodies), which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.
modulation of ESR1 (show ESR1 Antibodies)-MED1 interactions by cAMP signaling plays a critical role in human decidualization.
Our data indicate that MED1 serves as a key mediator in ARv567es induced gene expression
Results show that miR-1 (show FSD1 Antibodies) is downregulated in osteosarcoma cells but both of its targets Med1 and Med31 (show MED31 Antibodies) were overexpressed suggesting that MiR-1 (show FSD1 Antibodies) plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 and Med31 (show MED31 Antibodies).
MED1 is required for optimal PRDM16 (show PRDM16 Antibodies)-induced Ucp1 (show UCP1 Antibodies) expression
no association between SCZ and the SNPs of VDR (show CYP27B1 Antibodies), suggesting that VDR (show CYP27B1 Antibodies) is not a major gene for SCZ in Chinese Han population. However, our data indicate a potential involvement of VDR (show CYP27B1 Antibodies) SNPs in the susceptibility of risperidone-treated patients to MetS (show ETV3 Antibodies)
hyperactivated ERK (show EPHB2 Antibodies) and/or AKT (show AKT1 Antibodies) signaling pathways promoted MED1 overexpression in prostate cancer cells.
Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (show MBD4 Antibodies) plays role in enamel formation; Med1 (show MBD4 Antibodies) induces Alpl (show ALPL Antibodies) via stimulation of Notch1 (show NOTCH1 Antibodies) signaling by forming Notch1 (show NOTCH1 Antibodies)-RBP-Jk (show RBPJ Antibodies) complex on Alpl (show ALPL Antibodies) promoter. (Med1 (show MBD4 Antibodies) = mediator complex subunit 1; Alpl (show ALPL Antibodies) = alkaline phosphatase, liver-bone-kidney; Notch1 (show NOTCH1 Antibodies) = Notch gene homolog 1 (show NOTCH1 Antibodies); RBP-Jk (show RBPJ Antibodies) = kappa J region recombining binding protein suppressor of hairless (show RBPJ Antibodies))
MED1 (show MBD4 Antibodies) in macrophages has an antiatherosclerotic role via PPARgamma (show PPARG Antibodies)-regulated transactivation.
Cardiomyocyte-specific ablation of Med1 (show MBD4 Antibodies) causes lethal dilated cardiomyopathy in mice.
Med1 (show MBD4 Antibodies) deletion disrupted cardiac mitochondrial and metabolic gene expression patterns
Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop formation, are dynamically recruited to the IgH locus enhancers.
We conclude that MED1 (show MBD4 Antibodies) regulates the temporal progression of primary spermatocytes through meiosis, with its absence resulting in abbreviated pre-leptotene, leptotene, and zygotene stages, and a prolonged pachytene stage.
These results demonstrate that Med1 (show MBD4 Antibodies) is a master regulator in adult stem cells to govern epithelial cell fate
The novel function of MED1 (show MBD4 Antibodies) in keratinocytes.
PRDM16 (show PRDM16 Antibodies) deficiency in BAT (show BAAT Antibodies) reduces MED1 (show MBD4 Antibodies) binding at PRDM16 (show PRDM16 Antibodies) target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes
Collectively, these observations strongly suggest that MED1 (show MBD4 Antibodies) has an important affect on mitochondrial function.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.
, PPAR binding protein
, PPAR-binding protein
, PPARG binding protein
, TR-interacting protein 2
, activator-recruited cofactor 205 kDa component
, mediator of RNA polymerase II transcription subunit 1
, p53 regulatory protein RB18A
, peroxisome proliferator-activated receptor-binding protein
, thyroid hormone receptor-associated protein complex 220 kDa component
, thyroid hormone receptor-associated protein complex component TRAP220
, thyroid receptor interacting protein 2
, thyroid receptor-interacting protein 2
, vitamin D receptor-interacting protein 230 kD
, vitamin D receptor-interacting protein complex component DRIP205
, mediator complex subunit 1
, peroxisome proliferator-activated receptor binding protein
, membrane component, chromosome 17, surface marker 2
, Ppar binding protein
, peroxisome proliferator activated receptor binding protein