MED1 antibody

Catalog No. ABIN7259644

Product Details anti-MED1 Antibody

Target: MED1 (Mediator Complex Subunit 1 (MED1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED1 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human MED1 (NP_004765.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MED1

Target: MED1 (Mediator Complex Subunit 1 (MED1))

Alternative Name: MED1 (MED1 Products)

Synonyms: CRSP1 antibody, CRSP200 antibody, DRIP205 antibody, DRIP230 antibody, PBP antibody, PPARBP antibody, PPARGBP antibody, RB18A antibody, TRAP220 antibody, TRIP2 antibody, CRSP-1 antibody, MED1 antibody, pbp antibody, nbr1 antibody, crsp1 antibody, rb18a antibody, trip2 antibody, pparbp antibody, crsp200 antibody, drip205 antibody, drip230 antibody, ppargbp antibody, trap220 antibody, CG7162 antibody, Dmel\\CG7162 antibody, Med1 antibody, Med1/SOP3/TRAP220 antibody, Trap220 antibody, dTRAP220 antibody, AI480703 antibody, CRSP210 antibody, Pparbp antibody, l11Jus15 antibody, RGD1559552 antibody, mediator complex subunit 1 antibody, calcitonin-related polypeptide beta antibody, Mediator complex subunit 1 antibody, mediator of RNA polymerase II transcription subunit 1 antibody, MED1 antibody, CALCB antibody, med1 antibody, Med1 antibody

Background: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.

Molecular Weight:

Observed_MW: 160 kDa

Calculated_MW: 61 kDa/168 kDa

Gene ID: 5469

UniProt: Q15648

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha