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DRED is a 540 kDa complex containing the nuclear orphan receptors TR2 and TR4, which form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites. TR2 & 4 mRNAs are expressed at all stages of murine and human erythropoiesis.
TR2 that may exert an important repressor in regulating ER activity in mammary glands.
TR2 and TR4 can have distinct functions. Existence of differential and bi-directional regulation between PPAR alpha and TR2/TR4. Possible roles in PPAR alpha signaling pathway in human keratinocytes.
TR2 may function as a negative modulator to suppress androgen receptor function in prostate cancer. Further studies on how to control TR2 function may result in the ability to modulate AR function in prostate cancer.
The NF1-A transcription factor plays an important role in the transcriptional activation of the TR2 gene expression via a promoter activating cis-element.
This study supports a role for Nr2c1 in defining the biphasic period of retinal development and specifically influencing the early phase of retinal cell fate.
Nr2c1 may be a candidate for mediating parallel adaptive changes in cranial neural sensory specializations such as the olfactory epithelium, retina and mystacial vibrissae and in non-neural craniofacial features including teeth
TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes
in adult erythroid cells, TR2/TR4 bind to the embryonic beta-type globin promoters but not to the adult beta-globin promoter.
TR2 may not play essential roles in spermatogenesis and normal testis development, function, and maintenance. Alternatively, the roles of TR2 may be redundant and could be played by other close members of the nuclear receptor superfamily (TR2 receptor)
These results suggest a SUMOylation-dependent partitioning and differential coregulator recruitment contribute to the maintenance of a homeostatic supply of activating, Tr2, thus fine-tuning Oct4 expression and regulating stem-cell proliferation.
Silencing of the embryonic and fetal beta globin genes is delayed in erythroid cells of Tr2 and Tr4 null mutant mice, whereas in transgenic mice expressing dominant-negative TR4 (dnTR4), human embryonic epsilon-globin is activated in erythroid cells.
TR2 and TR4 orphan nuclear receptors repress Gata1 transcription.
Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression
Possible roles for TR2 and TR4 in early embryonic development by regulating key genes involved in stem cell self-renewal, commitment, and differentiation.
This is the first report identifying a deacetylase-independent function for HDAC3, which serves as a specific carrier molecule that targets a specifically phosphorylated protein to promyelocytic leukemia (PML) nuclear bodies.
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
nuclear receptor subfamily 2, group C, member 1
, Nuclear receptor subfamily 2 group C member 1
, TR2 nuclear hormone receptor
, nuclear receptor subfamily 2 group C member 1
, nuclear receptor subfamily 2, group C isoform
, orphan nuclear receptor TR2
, developmental orphan receptor 2
, developmental orphan receptor 2-A
, nuclear receptor subfamily 2 group C member 1-A
, orphan nuclear receptor TR2-A
, testicular receptor 2-A
, 80-3 cNDA
, early embryonic nuclear receptor
, nuclear receptor subfamily 2, group H, member 1
, orphan receptor, TR2-11
, testicular receptor 2
, pregnancy specific beta-1-glycoprotein 4