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results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha signaling, inhibiting the TLR4 (show TLR4 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (show TLR4 Proteins)/ERK1/2/AP-1 (show FOSB Proteins)/STAT3 (show STAT3 Proteins)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.
data suggested that miR (show MLXIP Proteins)-19a negatively controlled the autophagy of hepatocytes attenuated in D-GalN (show GAL Proteins)/LPS (show IRF6 Proteins)-stimulated hepatocytes via regulating NBR2 and AMPK (show PRKAA1 Proteins)/PPARalpha signaling.
The minor allele of rs1800206 and rs1805192 from PPAR A and PPAR G (show ARF6 Proteins) and its interaction were associated with increased Breast Cancer risk.
High concentrations of DINCH urinary metabolites activate human PPAR-alpha.
PPARalpha is overexpressed in primary glioblastoma
these results suggest that the E2F1 (show E2F1 Proteins)/miR19a/PPARalpha feedback loop is critical for glioma progression
Data conclude that the ER-stress mediated reduction in apoA-I (show APOA1 Proteins) transcription could be partly mediated via the inhibition of PPARalpha mRNA expression and activity. In addition, BET inhibition increased apoA-I (show APOA1 Proteins) transcription, even if PPARalpha production and activity were decreased. Both BET inhibition and PPARalpha activation ameliorate the apoA-I (show APOA1 Proteins) lowering effect of ER-stress and are therefore interesting targets to elev...
Results demonstrated that PPARa directly inhibited Glut1 (show SLC2A1 Proteins) mRNA expression resulting in influx of glucose in cancer cells.
PPARalpha and LXRalpha (show NR1H3 Proteins) may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Our results support an important association between rs1800206 minor allele of PPAR alpha and diabetic retinopathy, and the interaction analysis also shown a combined effect of Leu162 allele-abdominal obesity interaction on diabetic retinopathy.
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (show SLC22A5 Proteins) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (show PPARG Proteins)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (show PTGS2 Proteins) levels in bovine endometrial stromal cells.
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (show DGAT1 Proteins) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (show ADIPOR1 Proteins) (SSC10p13) and CREB (show CREB1 Proteins) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
The authors identify an endogenous role for PPARalpha in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. They also suggest PPARalpha as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits
p21 plays a relevant role in fasting adaptation through the positive regulation of PPARalpha.
PPARalpha is required for the ChREBP (show MLXIPL Proteins)-induced glucose response of FGF21 (show FGF21 Proteins). Loss of PPARalpha impairs Fgf21 (show FGF21 Proteins) promoter accessibility at the carbohydrate-responsive element .
Data, including data from studies in knockout mice, suggest that hepatic induction of cytochrome P450s (Cyp3a, Cyp2b, and Cyp2c) by hypolipidemic agent gemfibrozil is suppressed by Ppara activation.
We demonstrated that PPARalpha activation contributes to liver protection and decreases liver inflammation in acute liver failue (ALF (show GTF2A1L Proteins)), particularly through regulating CHOP (show DDIT3 Proteins). Our findings may provide a rationale for targeting PPARalpha as a potential therapeutic strategy to ameliorate ALF (show GTF2A1L Proteins).
These findings indicate that PPARalpha promotes osteogenic differentiation via the Sirt1 (show SIRT1 Proteins)-dependent signaling pathway.
CD36 (show CD36 Proteins) is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR)-related transcriptional responses in the muscle with exercise training.
In mice, the oral administration of linalool for 3 weeks reduced plasma TG concentrations in Western-diet-fed C57BL/6J mice (31%, P < 0.05) and human apo (show C9orf3 Proteins) E2 mice (50%, P < 0.05) and regulated hepatic PPARalpha target genes.
a novel PPARalpha-dependent gene
fenofibrate upregulated VLDLR (show VLDLR Proteins) transcriptional activity through PPAR response element binding to the VLDLR (show VLDLR Proteins) promoter.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor alpha
, ppar alpha
, xPPAR alpha
, peroxisome proliferator-activated receptor-alpha