Browse our Peroxisome Proliferator-Activated Receptor alpha Proteins (PPARA)

Human Peroxisome Proliferator-Activated Receptor alpha (PPARA) interaction partners

1. Improvements in metabolic and neurodegenerative diseases are often attributed to anti-inflammatory effects of PPAR activation. (Review)

2. circRNA_0046366, which demonstrated expression loss in HepG2-based hepatocellular steatosis, exerts antagonistic effect on miR (show MLXIP Proteins)-34a activity. miR (show MLXIP Proteins)-34a inactivation abrogates its inhibitory role against PPARalpha.

3. We first reported that the FOMX1 pathway is the most upregulated and the PPARalpha pathway is the most downregulated pathway in Triple Negative Breast Cancers (TNBCs). These two pathways could be simultaneously targeted in further studies. Also the pathway classifier we performed in this study provided insight into the TNBC heterogeneity.

4. Polymorphism of PPARA is associated with late onset of type 2 diabetes mellitus.

5. results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha signaling, inhibiting the TLR4 (show TLR4 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (show TLR4 Proteins)/ERK1/2/AP-1 (show FOSB Proteins)/STAT3 (show STAT3 Proteins)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.

6. data suggested that miR (show MLXIP Proteins)-19a negatively controlled the autophagy of hepatocytes attenuated in D-GalN (show GAL Proteins)/LPS (show IRF6 Proteins)-stimulated hepatocytes via regulating NBR2 and AMPK (show PRKAA1 Proteins)/PPARalpha signaling.

7. The minor allele of rs1800206 and rs1805192 from PPAR A and PPAR G (show ARF6 Proteins) and its interaction were associated with increased Breast Cancer risk.

8. High concentrations of DINCH urinary metabolites activate human PPAR-alpha.

9. PPARalpha is overexpressed in primary glioblastoma

10. these results suggest that the E2F1 (show E2F1 Proteins)/miR19a/PPARalpha feedback loop is critical for glioma progression

Cow (Bovine) Peroxisome Proliferator-Activated Receptor alpha (PPARA) interaction partners

1. This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.

2. OCTN2 (show SLC22A5 Proteins) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.

3. In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.

4. Data suggest that PPARalpha (but not PPARgamma (show PPARG Proteins)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.

5. Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.

6. Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.

7. Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.

8. The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (show PTGS2 Proteins) levels in bovine endometrial stromal cells.

Pig (Porcine) Peroxisome Proliferator-Activated Receptor alpha (PPARA) interaction partners

1. Our results provide novel insights into regulation of PPAR expression in ovarian follicles. We observed that FSH (show BRD2 Proteins) increased mRNA and protein expression of all PPARs isoforms, while LH only increased PPAR alpha and gamma. Steroids like progesterone and estradiol increased expression of PPAR alpha and gamma without affecting the beta isoform, while testosterone had no effect on all PPARs expression.

2. The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.

3. The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.

4. PPARalpha is likely to play a central role in adaptation to fasting in pig liver

5. Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.

6. FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (show DGAT1 Proteins) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (show ADIPOR1 Proteins) (SSC10p13) and CREB (show CREB1 Proteins) (SSC15q24)

7. PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.

Xenopus laevis Peroxisome Proliferator-Activated Receptor alpha (PPARA) interaction partners

Mouse (Murine) Peroxisome Proliferator-Activated Receptor alpha (PPARA) interaction partners

1. These data may indicate that insulin (show INS Proteins) resistance in Adp(-/-) mice is likely caused by an increase in concentrations of TNFalpha (show TNF Proteins) and FFA via downregulation of PPARalpha.

2. Results from transcriptional and epigenomic analyses in the livers of mice fed either a high-fat diet or nutrition-restricted diet, found extensive binding of PPARalpha near genes involved in glycolysis/gluconeogenesis and uncovered a role for this factor in regulating anaerobic glycolysis.

3. Peroxisome proliferator-activated receptor alpha (PPARalpha) target gene expression was almost absent in contrast to increased lipid synthesis in the TIS21 (show BTG2 Proteins) protein (TIS21 (show BTG2 Proteins)) knockout (TIS21 (show BTG2 Proteins)-KO) mice compared to WT mice.

4. Clofibrate treatment revealed an essential role of PPARalpha in regulating hepatic bile acid synthesis, transport and signaling.

5. IL-6 and aging are involved in regulation of PPARalpha and PGC-1alpha expression and may influence the mitochondrial function.

6. The authors identify an endogenous role for PPARalpha in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. They also suggest PPARalpha as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits

7. p21 plays a relevant role in fasting adaptation through the positive regulation of PPARalpha.

8. PPARalpha is required for the ChREBP (show MLXIPL Proteins)-induced glucose response of FGF21 (show FGF21 Proteins). Loss of PPARalpha impairs Fgf21 (show FGF21 Proteins) promoter accessibility at the carbohydrate-responsive element .

9. Data, including data from studies in knockout mice, suggest that hepatic induction of cytochrome P450s (Cyp3a, Cyp2b, and Cyp2c) by hypolipidemic agent gemfibrozil is suppressed by Ppara activation.

10. We demonstrated that PPARalpha activation contributes to liver protection and decreases liver inflammation in acute liver failue (ALF (show GTF2A1L Proteins)), particularly through regulating CHOP (show DDIT3 Proteins). Our findings may provide a rationale for targeting PPARalpha as a potential therapeutic strategy to ameliorate ALF (show GTF2A1L Proteins).