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Human Retinoic Acid Receptor alpha Protein expressed in Wheat germ - ABIN1317431
Schulz, Paus, Frey, Schmid, Kohl, Mennerich, Winkler, Gillardon: Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. in PLoS ONE 2011
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Our findings unveil a novel essential oncogenic activity of PML (show PML Proteins)/RARA in Acute promyelocitic leukemia
Findings reveal a previously unrecognized role of c-Myc (show MYC Proteins) as a potential ceRNA for PML (show PML Proteins)/RARalpha in acute promyelocytic leukemia (show PML Proteins).
RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway
It has been shown that the AP-1 (show FOSB Proteins) family member JunB (show JUNB Proteins) and retinoic acid receptor alpha (RARa) mediate catalase (show CAT Proteins) transcriptional activation and repression, respectively, by controlling chromatin remodeling through a histone deacetylases-dependent mechanism.
Work identifies the TP53 (show TP53 Proteins) tumor suppressor as a novel target through which NPM1 (show NPM1 Proteins)-RARA impacts leukemogenesis.
Dual small interfering RNA (siRNA) silencing of RARalpha and RARgamma reversed RA blockade of P4-induced CK5 (show KRT5 Proteins). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (show KRT5 Proteins) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
High RARA expression is associated with acute myeloid leukemia (show BCL11A Proteins).
Data suggest that the binding of Z-10 to RXRalpha (show RXRA Proteins) inhibited the interaction of RXRalpha (show RXRA Proteins) with PML (show PML Proteins)-RARalpha, leading to Z-10's selective induction of PML (show PML Proteins)-RARalpha degradation.
PML (show PML Proteins)-RARa bcr1 (show BCR Proteins) fusion is not responsible for colorectal tumor development.
overexpression of NLS (show ALDH1A2 Proteins)-RARalpha promoted the proliferation of APL (show FASL Proteins) cells and inhibited their differentiation via the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway.
RARalpha competes with other PFN2a-binding proteins bearing PRMs and involved in actin filaments elongation. Consequently, the actin filament network is altered and MEFs adhesion is decreased. This novel role opens novel avenues for the understanding of pathologies characterized by increased levels of cytoplasmic RARalpha.
These data suggest that impairment of cardiac RARalpha signaling may be a novel mechanism that is directly linked to pathological stimuli-induced diastolic dysfunction.
Retinoic acid receptor alpha agonist all trans retinoic acid can protect the liver from ischemia reperfusion injury by promoting autophagy, which is dependent on Foxo3 (show FOXO3 Proteins)/p-Akt (show AKT1 Proteins)/Foxo1 (show FOXO1 Proteins) signaling.
both the PML (show PML Proteins)-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) required DNMT3A (show DNMT3A Proteins)
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (show WNT2 Proteins) signalling through physical interactions of RARs (show RARS Proteins) with beta-catenin (show CTNNB1 Proteins).
our findings challenge the predominant model in the field and we propose that PML (show PML Proteins)/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.
DNA-binding-defective PML (show PML Proteins)/RARA mutants could not repress the transcription of retinoic acid regulated genes.
although X-RARA fusion proteins have been suggested to act by blocking retinoid-dependent transcriptional programs , we observed a surprising paucity of natural retinoids capable of transactivating Gal4 (show LGALS4 Proteins)-RARA in primary mouse bone marrow cells
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha and RARgamma in bone structure regulation.
Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Proteins)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (show SP1 Proteins) via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.
Increased expression of mammary TRbeta1 (show THRB Proteins) and DIO2 (show DIO2 Proteins), and decreased RXRalpha (show RXRA Proteins), provide a mechanism to increase thyroid hormone (show PTH Proteins) activity within the mammary gland during lactation.
results show role for retinoic acid receptor (show RARB Proteins) as a regulator of spatial patterning of the pre-placodal ectoderm (PPE)through Tbx1 and RIPPLY3; demonstrate that Ripply3, acting downstream of RAR (show RAB40B Proteins) signaling, is key player in establishing boundaries in the PPE
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
retinoic acid receptor alpha
, retinoic acid receptor, alpha
, retinoic acid receptor alpha-like
, nuclear receptor subfamily 1 group B member 1
, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
, retinoic acid nuclear receptor alpha variant 1
, retinoic acid nuclear receptor alpha variant 2
, retinoic acid receptor, alpha polypeptide
, RAR alpha 1
, rar alpha
, xRAR alpha
, retinoic acid receptor alpha 1 isoform