Browse our anti-Retinoid X Receptor alpha (RXRA) Antibodies

Human Retinoid X Receptor, alpha (RXRA) interaction partners

1. RXRalpha provokes tumor suppression through p53/p21/p16 and PI3K-AKT signaling pathways during stem cell differentiation and in cancer cells.

2. Knockdown of RXRA induces the production of reactive oxygen species (ROS) and DNA damage via the ITPR2-MCU calcium signaling axis and consequently triggers cellular senescence by activating p53, whereas RXRA overexpression decreases DNA damage accumulation and then delays replicative senescence.

3. FXR and RXR bind to the transcriptional coregulator steroid receptor coactivator 1 with higher affinity when they are part of the heterodimer complex than when they are in their respective monomeric states.

4. ENHO, RXRA, and LXRA polymorphisms and dyslipidemia, related comorbidities and survival in hemodialysis patients have been reported.

5. tRXRalpha was expressed in colorectal tissues from ulcerative colitis patients while tRXRalpha was barely detected in colorectal tissues from healthy individuals.

6. there is a novel, so far uncharacterized cistromic crosstalk between RXR and STAT6.

7. the rs11638944:C>G transversion exerts a cis-acting effect on the expression levels of LOXL1, mediated by differential binding of the transcription factor retinoid X receptor alpha and by modulating alternative splicing of LOXL1, eventually leading to reduced levels of LOXL1 mRNA in cells and tissues of risk allele carriers for pseudoexfoliation syndrome

8. RXRA SNPs are not associated with vitamin D status and multiple sclerosis.

9. This review analyzes the non-genomic effects of RXRA in normal and tumor cells, and discusses the functional differences based on RXRA protein structure (structure source: the RCSB Protein Data Bank). [review]

10. The results showed that overexpression of RXRalpha was correlated with unfavorable prognosis, suggesting that RXRalpha may serve as a potential targeted therapeutic marker in the treatment of Esophageal carcinoma (EC).

11. we found that RXRalpha was upregulated in head and neck squamous cell carcinoma

12. Single nucleotide polymorphism rs11185644 near the RXRA was significantly associated with 25-Hydroxyvitamin D dose-response.

13. Variability in the methylation status of the RXRalpha promoter near the EGR transcription factor binding site in newborn cord blood provides controversial epigenetic insights into RXRalpha regulation via EGR proteins.

14. Here, the authors characterize mutant RXRA, demonstrating it induces enhancer/promoter activity in the context of RXRA/PPAR heterodimers in human bladder cancer cells.

15. Loss of RXRA is associated with Non-Small Cell Lung Cancer.

16. These findings unveil RXRalpha as an important cellular factor in modulating HBV infection and may point to a new strategy for host-targeted therapies against HBV.

17. RXRalpha regulates HBV replication in and minichromosome remodeling.

18. Findings indicate that Gc globulin (GC) rs16847024, retinoid X receptor gamma (RXRG) rs17429130 and retinoid X receptor alpha (RXRA) rs4917356 were candidate susceptibility markers for gestational diabetes mellitus (GDM) in Chinese females.

19. retinoic acid receptor beta-retinoic X receptor alpha heterodimer quaternary architecture variable

20. Immune cell-infiltration is controlled by activated peroxisome proliferator activated receptor gamma (PPARgamma)/retinoid X receptor alpha (RXRalpha) that inhibits expression/secretion of inflammatory cytokines.

Mouse (Murine) Retinoid X Receptor, alpha (RXRA) interaction partners

1. RARalpha signaling in interneurons is crucial for visual deprivation-induced homeostatic synaptic plasticity in visual cortical circuits.

2. Transgenic expression of truncated RXRalpha in mice accelerates the development of colitis-associated colon cancer (CAC). The tumorigenic effect of truncated RXRalpha is primarily dependent on its expression in myeloid cells, which results in interleukin-6 (IL-6) induction and STAT3 activation.

3. Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease

4. Loss of RXRA is associated with Non-Small Cell Lung Cancer.

5. Mice lacking the RXR-alpha receptor develop spontaneous melanoma following a single ultraviolet radiation exposure compared to mice with functional RXR-alpha receptor.

6. The primary aim of the present study was to investigate the potential of Nur77 in Amyloid betainduced neuron apoptosis, and to evaluate the effect of RXRalpha nuclear export inhibition on neuronal apoptosis.

7. These data suggest that RXRs may be of crucial importance in the mechanism of allergic asthma and that the novel RXR partial agonist NEt-4IB may be a promising candidate for the treatment of allergic airway inflammation and airway hyperresponsiveness in a model of allergic asthma.

8. The study shows that FXR/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.

9. These results suggest a mechanism to establish RXR therapeutic targets with significance in neurodegeneration.

10. The optimal PPARalpha/RXRalpha heterodimer binding sequence was WAWVTRGGBBAHRGKTYA. The single nucleotide substitution, which reduces binding of RXRalpha to DNA, attenuated PPARalpha-induced transcriptional activation, but this is not always true for PPARalpha.

11. A change in the heterodimeric partner of Peroxisome Proliferator Activated Receptor-alpha from retinoid X receptor to Silent information regulator 1 is responsible for the impaired fatty acid metabolism and cardiac dysfunction in the failing heart.

12. interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma

13. a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN

14. This uncovered a novel RXR-dependent innate immune regulatory pathway, suggesting that downregulation of RXR expression or RXR antagonist treatment benefits host antiviral response, whereas RXR agonist treatment may increase risk of viral infections.

15. Data suggest that retinoic acid and GM-CSF-induced retinal dehydrogenase 2 (RALDH2) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor complex to the Aldh1a2 promoter.

16. The expression and binding of RXRalpha to CYP3A genes in liver was sex-dependent and regulated by growth hormone secretion.

17. The depletion of retinoic acid and the inhibition of RXRalpha function in hepatic tumors involve more complex mechanisms besides the activation of RAS/ERK pathway.

18. These observations suggest that beta-apo-13-carotenone regulates RXRalpha transcriptional activity by inducing the formation of the "transcriptionally silent" RXRalpha tetramer.

19. RXRs modulate post-UVR survival of dermal fibroblasts in a "non-cell autonomous" manner, underscoring their role in immune surveillance, while independently mediating post-UVR melanocyte survival in a "cell autonomous" manner

20. Drupanin, a component of BGP, is a novel RXR agonist with slight PPARgamma agonistic activity.

Pig (Porcine) Retinoid X Receptor, alpha (RXRA) interaction partners

1. Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.