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anti-Human Retinoid X Receptor alpha Antibodies:
anti-Mouse (Murine) Retinoid X Receptor alpha Antibodies:
anti-Rat (Rattus) Retinoid X Receptor alpha Antibodies:
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Human Polyclonal Retinoid X Receptor alpha Primary Antibody for ELISA, WB - ABIN2476395
Stewart, Tuffnell: Cloning the cDNA for horse growth hormone and expression in Escherichia coli. in Journal of molecular endocrinology 1991
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Human Monoclonal Retinoid X Receptor alpha Primary Antibody for EMSA, IP - ABIN2668713
Subbarayan, Mark, Messadeq, Rustin, Chambon, Kastner: RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses. in The Journal of clinical investigation 2000
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Human Polyclonal Retinoid X Receptor alpha Primary Antibody for ELISA, WB - ABIN250299
Claudel, Leibowitz, Fiévet, Tailleux, Wagner, Repa, Torpier, Lobaccaro, Paterniti, Mangelsdorf, Heyman, Auwerx: Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. in Proceedings of the National Academy of Sciences of the United States of America 2001
the rs11638944:C>G transversion exerts a cis (show CISH Antibodies)-acting effect on the expression levels of LOXL1 (show LOXL1 Antibodies), mediated by differential binding of the transcription factor retinoid X receptor alpha and by modulating alternative splicing of LOXL1 (show LOXL1 Antibodies), eventually leading to reduced levels of LOXL1 (show LOXL1 Antibodies) mRNA in cells and tissues of risk allele carriers for pseudoexfoliation syndrome
RXRA SNPs are not associated with vitamin D status and multiple sclerosis.
This review analyzes the non-genomic effects of RXRA in normal and tumor cells, and discusses the functional differences based on RXRA protein structure (structure source: the RCSB Protein Data Bank). [review]
The results showed that overexpression of RXRalpha was correlated with unfavorable prognosis, suggesting that RXRalpha may serve as a potential targeted therapeutic marker in the treatment of Esophageal carcinoma (EC).
we found that RXRalpha was upregulated in head and neck squamous cell carcinoma
Single nucleotide polymorphism rs11185644 near the RXRA was significantly associated with 25-Hydroxyvitamin D dose-response.
Variability in the methylation status of the RXRalpha promoter near the EGR (show EGR1 Antibodies) transcription factor binding site in newborn cord blood provides controversial epigenetic insights into RXRalpha regulation via EGR (show EGR1 Antibodies) proteins.
Here, the authors characterize mutant RXRA, demonstrating it induces enhancer/promoter activity in the context of RXRA/PPAR (show PPARA Antibodies) heterodimers in human bladder cancer cells.
Loss of RXRA is associated with Non-Small Cell Lung Cancer.
These findings unveil RXRalpha as an important cellular factor in modulating HBV infection and may point to a new strategy for host-targeted therapies against HBV.
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease
Mice lacking the RXR-alpha receptor develop spontaneous melanoma following a single ultraviolet radiation exposure compared to mice with functional RXR-alpha receptor.
The primary aim of the present study was to investigate the potential of Nur77 (show NR4A1 Antibodies) in Amyloid betainduced neuron apoptosis, and to evaluate the effect of RXRalpha nuclear export inhibition on neuronal apoptosis.
These data suggest that RXRs may be of crucial importance in the mechanism of allergic asthma and that the novel RXR partial agonist NEt-4IB may be a promising candidate for the treatment of allergic airway inflammation and airway hyperresponsiveness in a model of allergic asthma.
The study shows that FXR (show NR1H4 Antibodies)/RXR regulates Chop (show DDIT3 Antibodies) expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
These results suggest a mechanism to establish RXR therapeutic targets with significance in neurodegeneration.
The optimal PPARalpha (show PPARA Antibodies)/RXRalpha heterodimer binding sequence was WAWVTRGGBBAHRGKTYA. The single nucleotide substitution, which reduces binding of RXRalpha to DNA, attenuated PPARalpha (show PPARA Antibodies)-induced transcriptional activation, but this is not always true for PPARalpha (show PPARA Antibodies).
A change in the heterodimeric partner of Peroxisome Proliferator Activated Receptor-alpha (show PPARA Antibodies) from retinoid X receptor (show RXRB Antibodies) to Silent information regulator 1 is responsible for the impaired fatty acid metabolism and cardiac dysfunction in the failing heart.
interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
nuclear receptor subfamily 2 group B member 1
, retinoic acid receptor RXR-alpha
, retinoid X nuclear receptor alpha
, RXR alpha 1
, retinoid X receptor, alpha
, retinoic acid receptor
, retinoid x receptor alpha
, retinoid X receptor alpha
, retinoid X receptor alpha protein
, nuclear receptor subfamily 2 group B member 1-B
, retinoic acid receptor RXR-alpha-B
, retinoid X receptor alpha-B
, retinoid x receptor, gamma