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anti-Mouse (Murine) Vitamin D Receptor Antibodies:
anti-Rat (Rattus) Vitamin D Receptor Antibodies:
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Chemical Polyclonal Vitamin D Receptor Primary Antibody for IF (p), IHC (p) - ABIN682513
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
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Chemical Polyclonal Vitamin D Receptor Primary Antibody for IHC (p), WB - ABIN3043960
Gao, Wang, Yan, Zeng, Ma, Niu, Zhou, Jiang, Chen: Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats. in PLoS ONE 2016
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Chemical Polyclonal Vitamin D Receptor Primary Antibody for WB - ABIN3042969
Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR. in American journal of translational research 2017
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Chemical Monoclonal Vitamin D Receptor Primary Antibody for IHC (p) - ABIN2477108
Ditsch, Toth, Mayr, Lenhard, Gallwas, Weissenbacher, Dannecker, Friese, Jeschke: The association between vitamin D receptor expression and prolonged overall survival in breast cancer. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012
Chemical Polyclonal Vitamin D Receptor Primary Antibody for ELISA, WB - ABIN2477107
Cheng, Chen, Huang, Chang, Hung: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. in Journal of cellular biochemistry 2006
Dog (Canine) Polyclonal Vitamin D Receptor Primary Antibody for ELISA, WB - ABIN547464
Malerba, Pignatti: A review of asthma genetics: gene expression studies and recent candidates. in Journal of applied genetics 2005
Human Monoclonal Vitamin D Receptor Primary Antibody for DB, WB - ABIN4251062
Momen-Heravi, Masugi, Qian, Nishihara, Liu, Smith-Warner, Keum, Zhang, Tchrakian, Nowak, Yang, Ma, Bowden, da Silva, Wang, Fuchs, Meyerhardt, Ng, Wu, Giovannucci, Ogino, Zhang: Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. in International journal of cancer 2017
Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
zebrafish embryos lacking vdrb produced fewer sensory hair cells in the ears and showed disruption of balance and motor coordination.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
investigation of binding of ligands that induce significant conformational changes at the protein level
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
While further studies are required to determine the mechanisms, by which vitamin D activity regulates osteoclastic bone resorption, our findings suggest that VDR-mediated activity in mature osteoclasts is required to moderate osteoclastic activity during growth and in ovariectomy-induced bone loss.
Our data indicate abnormal osteoclastogenesis due to the absence of Vdr expression, consistent with direct effects of vitamin D signalling being important for regulating the maturation and resorptive activities of osteoclasts.
We conclude that the relative VDR level and the 1,25D availability to cells, are important co-determinants for whether 1,25D plays a promoting or suppressive role in osteoblast-mediated osteogenic activity.
Taken together, our in vivo studies using ChIP-seq analyses and the mini-gene transgenic mice improve our understanding of the tissue-specific regulatory mechanisms of controlling VDR expression and the mechanisms of action of the VDR.
Low VDR expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer.
These findings suggest that Vdr has a cell-intrinsic function in early erythroid progenitors.
Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Activated RAS signaling reduced Vitamin D Receptor (VDR) level in intestinal epithelial cells.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut inflammation.
Unique protective roles for vitamin D signaling during colitis in the colon epithelium as well as nonepithelial cells in the colon microenvironment (i.e., modulation of M biology).
Vdr and Casr are required for beta-catenin-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
Study is the first to describe the A61894G polymorphism, which is in linkage disequilibrium with T61968C, and its association with leprosy occurrence in Brazilian patients. According to analysis, both polymorphisms are closely linked to disease development and study suggests that the combined genotype TCAA favors leprosy susceptibility.
Results show that colorectal cancer (CRC) subjects had lower serum 25(OH)D levels and higher VDR gene expression, and these were negatively correlated in the CRC group. VDR DNA methylation at position 4 had lower levels in the CRC group.
This study investigated specific interactions between vitamin D receptor (VDR) and its ligand. The difference in chirality of ligands causes the difference in Histidine protonations.
Non-obese participants had significantly lower mean VDR gene expression in visceral adipose tissues than both the obese and morbidly obese ones and had also lower expression in subcutaneous adipose tissues than the morbidly obese participants.
rs2228570 of VDR might be a moderate risk factor for breast cancer development in the Ethiopian population
Genetic variations in the VDR were not associated with five different measurements of muscle strength or physical performance (hand grip strength right and left, 6 m walking test (easy and narrow) and timed-stands test). However, one of the 7 Single Nucleotide Polymorphisms of the gene for the VDR receptor, rs7136534, was associated with prevalence of falls (33.6% of the AA, 14.6% of the AG and 16.5% of the GG allele).
The aim of the study was to verify the relationship between polymorphisms of the vitamin D receptor gene (VDR), clinical findings, and serum vitamin D (VD) levels in asthmatics
This study demonstrated that the protective effect of the VDR FokI FF genotype on lipid profile in juvenile idiopathic arthritis patients treated with etanercept.
Polymorphic alleles and genotypes of the VDR gene can be used as predictors of arterial hypertension development in obese patients with subsequent characterization of the state of the renin-angiotensin-aldosterone-system system
VDR and VDBP mutations were found highly related with Obstructive sleep apnea syndrome.
In summary, this case-control study conducted in the Henan rural population identified two novel polymorphic loci (rs2189480 and rs3847987) of the VDR gene that are associated with the risk of developing T2DM. We also found that these two polymorphic loci can interact with the risk factor of low physical activity to increase the risk of T2DM development.
that the genetic variants of vitamin D receptor and group-specific component genes contribute to genetic predisposition to lumbar disc degeneration in Iran
VDRE binding and co-activator recruitment by VDR appear to be functionally inseparable events that affect vitamin D-elicited gene transcription.
25(OH)D concentrations were associated with DNA methylation of CpGs in several vitamin D-related genes, with potential links to immune function-related genes. Methylation of CpGs in vitamin D-related genes may interact with 25(OH)D to affect the risk of breast cancer.
Functional SNPs of VDR gene including rs739837, rs3847987 and rs2228570 might be irrelevant to the pathogenesis of idiopathic hypoparathyroidism
Vitamin D receptor (VDR) BsmI gene polymorphism is associated with chronic renal failure risk in the Chinese and Spanish individuals. VDR FokI gene polymorphism is associated with CRF risk in Asian subjects.
Fok1 genotype and f allelic frequencies may be susceptible risk factors for Systemic Lupus Erythematosus rather than Osteoarthritis in Egyptian patients.
Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk.
VDR rs2228570 AG genotype is at a decreased risk and the GG genotype is at an increased risk of lumbar degenerative disc disease in the Turkish population
the SNP rs10735810 allele A in the VDR gene promoter region may influence the level of serum calcium, but not influence the formation of nephrolithiasis in a Han Chinese population.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein