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Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR (show CYP27B1 Proteins) inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe (show APOE Proteins)(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Activated RAS signaling reduced Vitamin D Receptor (VDR) level in intestinal epithelial cells.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut (show GUSB Proteins) inflammation.
Vdr (show CYP27B1 Proteins) and Casr (show CASR Proteins) are required for beta-catenin (show CTNNB1 Proteins)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
Absence of VDR-mediated PPARgamma suppression underlies alopecia in VDR-/- mice.
Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses.
VDR (show CYP27B1 Proteins) is important for the maintenance of physiological level of Axin1 (show AXIN1 Proteins)
The data support the hypothesis that Vdr in mature adipocytes alters the metabolic response to high-fat diets and exerts anti-proliferative effects on the mammary epithelium.
binds vitamin D3\; acts as a transcriptional regulator of the osteocalcin gene
vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D3 receptor
, vitamin D receptor
, vitamin D receptor alpha
, vitamin D receptor beta
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1