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Human BAX Protein expressed in Wheat germ - ABIN1346446
Kim, Kim, Park, Hwang, Kim, Lee, Kang, Um: Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax. in Cellular signalling 2012
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Bid (show BID Proteins) and Bax are signal transduction factors in granulosa cells and play proapoptotic roles.
The data demonstrate that severe hypocapnia results in increased Bax expression, DNA fragmentation, and membrane lipid peroxidation in mitochondria of cerebral cortical neurons of newborn piglets, and may result in apoptotic cell death.
BoHV-5 replication apparently modulates BCL-2 (show BCL2 Proteins) expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
It was concluded that the Fas (show FAS Proteins)-FasL (show FASL Proteins) signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (show TDO2 Proteins) cell lymphoma/leukemia-2 associated X upregulation.
apoptosis-inducing factor (show AIFM1 Proteins) was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 (show BCL2 Proteins) protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax, Bcl-2 (show BCL2 Proteins), caspase-3 (show CASP3 Proteins) and-7 cannot be used as a reliable apoptosis detection method.
The effect of culture conditions on expression of heat shock protein 70 (show HSP70 Proteins) and Bax protein in bovine blastocysts is reported.
xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis.
These results suggest a role for mitochondrial p53 (show TP53 Proteins) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2 (show BCL2 Proteins).
our data present preliminary evidence that inherited abnormalities in the intrinsic apoptosis pathway, related to BAX G(-248)A and BCL2 (show BCL2 Proteins) C(-717)A SNPs, are associated with treatment response and act as independent prognostic factors in DLBCL.
SFRP5 (show SFRP5 Proteins) confers protection against oxidative stress-induced (show SQSTM1 Proteins) apoptosis through inhibition of beta-catenin (show CTNNB1 Proteins) activation and downregulation of Bax.
The ratio of Bax/Bcl-2 (show BCL2 Proteins) was significantly enhanced by the Ginsenoside Rg3 to Paclitaxel.
this study show that PATZ1 (show ZNF278 Proteins) expression correlates positively with BAX and negatively with BCL6 (show BCL6 Proteins) and survival in human diffuse large B cell lymphomas
YY1 (show YY1 Proteins) promotes apoptosis via upregulating Bax transcription and subsequent activation of Bax by translocation from the cytosol to the mitochondrial membrane.
Immunohistochemical analysis showed that STAT3 (show STAT3 Proteins), GRP78 (show HSPA5 Proteins) and BAX protein levels in the combination group were significantly higher than those in STAT3 (show STAT3 Proteins) group and CDDP group (P<0.05). Exogenous STAT3 (show STAT3 Proteins) and CDDP may synergistically inhibit the xenograft tumour growth through up-regulation of BAX protein via GRP78 (show HSPA5 Proteins).
This is the first study evaluating the potential relationship between BCL2 (show BCL2 Proteins) and BAX gene polymorphisms and RRD (show DHRS4 Proteins) in a Greek population, showing a significant association between BAX rs4645878 polymorphism and RRD (show DHRS4 Proteins) susceptibility. This finding suggests that an apoptotic mechanism is implicated in the pathogenesis of RRD (show DHRS4 Proteins)
Heavy ion irradiation could induce p53 (show TP53 Proteins)(-/-) hepatoma cells to undergo apoptosis via E2F1 (show E2F1 Proteins)/Bax/Casp3 (show CASP3 Proteins) signaling pathway.
Bax effects were dependent on its oligomeric state. Monomeric Bax did not affect the membrane, oligomeric Bax lowered the breakthrough force of the membrane, which in the context of pore formation, implies a lowering of the line tension at the edge of the pore.
The results strongly suggest that the direct apoptosis-activation activities of Bid (show BID Proteins), Bim (show BCL2L11 Proteins), Puma (show BBC3 Proteins), and p53 (show TP53 Proteins) are not essential for activating Bax/Bak (show BAK1 Proteins) once the anti-apoptotic Bcl-2 (show BCL2 Proteins) proteins are neutralized.
although all CR subtypes undergo cell death, septum, but not hem, CRs (show CARS Proteins) die in a Bax-dependent manner. Bax-inactivated rescued septum-CRs (show CARS Proteins) maintain immature electrophysiological properties
An autoinhibited dimeric form of BAX regulates the cytosolic BAX activation pathway.
Postnatal synaptic rearrangement needed for acquisition of skilled behaviors requires the activity-dependent, non-apoptotic Bax/Bak (show BAK1 Proteins)-caspase (show CASP3 Proteins) signaling cascade. Adult Bax/Bak (show BAK1 Proteins) mutant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval behaviors.
Study found that emphysema occurred in ku70(-/-) mice at the age of three-months old, and that Bax deficiency was able to suppress it. These results suggest that Bax-mediated apoptosis induces emphysema in ku70(-/-) mice.
The polyglutamine embedded in the ER membrane was observed at the same time as Bax insertion. These results demonstrated that the ER membrane may be a target of polyglutamine, which triggers cell death through Bax.
These results suggest that Bax mediates beta-cell apoptosis in Pdx1 (show PDX1 Proteins)-deficient diabetes.
Bim (show BCL2L11 Proteins) and Puma (show BBC3 Proteins) overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.
This study demonstated that Bax KO mice show Hyperactivity and depression.
The influence of chronic ethanol consumption on the expression of the Bdnf (show BDNF Proteins), Bax, Bcl-xL (show BCL2L1 Proteins), and CASP3 (show CASP3 Proteins) genes was studied in the brain structures of B6-1473C (C/C) and B6-1473G (G/G) mice that had been obtained on the base of the C57BL/6 strain.
These data indicate that the rapid and robust microglial activation and PIF (show DCD Proteins) expression observed in situ following acute EtOH exposure is largely driven indirectly by BAX-dependent apoptotic cell death, rather than directly by the EtOH.
The content of Bax protein in the cardiomyocyte cytoplasm decreased, thus indicating that the mitochondrial pathway was not involved in the realization of the apoptotic program in a model of ventricular overload.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax and decreasing expression of bcl2 (show BCL2 Proteins).
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 (show BCL2 Proteins) and increased expression of Bax.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2-associated X protein (BAX) transcripts and protein depending on luteal stage.
bcl-2 (show BCL2 Proteins) and bax were expressed strongly in denervated guinea-pig facial muscle. [bcl-2 (show BCL2 Proteins); bax]
goat oocytes based on G6PDH (show G6PD Proteins)-activity through the BCB test improves their developmental competence, increases intracellular GSH content, and affects the expression of the apoptosis-related genes9 Bax and Bcl-2 (show BCL2 Proteins) ).
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
BCL2-associated X protein
, BCL2-associated protein
, apoptosis regulator BAX
, bax zeta
, BCL2-associated X protein omega
, BCL2-associated X protein transcript variant delta2
, bcl-2-like protein 4