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PUMA Proteins

(BCL2 Binding Component 3 (BBC3))
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
PUMA Protein (AA 141-261) (His-IF2DI Tag) PUMA Protein (AA 141-261) (His-IF2DI Tag) PUMA Protein (AA 141-261) (His-IF2DI Tag) (ABIN7121980)

BBC3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA

PUMA Protein (AA 1-261) (His tag) PUMA Protein (AA 1-261) (His tag) PUMA Protein (AA 1-261) (His tag) (ABIN3089925)

Crystallography grade BBC3 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

PUMA Protein (AA 1-193) (His tag) PUMA Protein (AA 1-193) (His tag) PUMA Protein (AA 1-193) (His tag) (ABIN3089700)

Crystallography grade BBC3 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

PUMA Proteins by Grade

Find PUMA Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PUMA Proteins by Origin

Find PUMA Proteins for a variety of species such as anti-Human PUMA, anti-Rat PUMA, anti-Mouse PUMA. The species listed below are among those available. Click on a link to go to the corresponding products.

PUMA Proteins by Source

Here you will find PUMA Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PUMA Proteins by Protein Type

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PUMA Proteins by Application

Find PUMA Proteins validated for a specific application such as ELISA, WB, SDS, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PUMA Proteins by Biological Activity

Find PUMA Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular PUMA Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7121980
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3089925
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3089700
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3128059
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2730162
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7504951
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7319938
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395239
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2468998
Quantity 0.05 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2730161
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1623829
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PUMA Proteins

Carpenter, Han, Paw, Lo: "HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells." in: PLoS ONE, Vol. 8, Issue 11, pp. e78836, (2013) (PubMed).

Aliases for PUMA Proteins

BCL2 binding component 3 (BBC3) Proteins
Bcl-2 binding component 3 (Bbc3) Proteins
BCL2 binding component 3 (Bbc3) Proteins
BCL2 binding component 3 (bbc3) Proteins
BBC3 Proteins
JFY-1 Proteins
JFY1 Proteins
Puma Proteins
PUMA Proteins
PUMA/JFY1 Proteins
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