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Full name:: V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) Proteins (MYC)

On www.antibodies-online.com are 30 V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) Proteins from 8 different suppliers available. Additionally we are shipping C-MYC Antibodies (917) and C-MYC Kits (62) and many more products for this protein. A total of 1032 C-MYC products are currently listed.

Synonyms:: anon-WO03040301.171, AU016757, bHLHe39, bHLHe57, c-MYC, c-myc II, CG10798, CMyc, d-myc, da, dm, dm/dMyc, dm/myc, Dmel\CG10798, dmyc, dmyc1, EG:BACN5I9.1, l(1)G0139, l(1)G0354, l(1)G0359, LOC100136746, mMyc, MRTL, myc, myc-B, myc2, MYCC, Niard, Nird, RNCMYC, zc-myc

list all proteins	Gene Name	GeneID	UniProt
	MYC	4609	P01106
	MYC	24577	P09416
	MYC	17869	P01108
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C-MYC Proteins (MYC) by Origin

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Top referenced C-MYC Proteins

Human C-MYC Protein expressed in HEK-293 Cells - ABIN2715370 : Garcia-Sanz, Quintanilla, Lafita, Moreno-Bueno, García-Gutierrez, Tabor, Varela, Shiio, Larsson, Portillo, Leon: Sin3b interacts with Myc and decreases Myc levels. in The Journal of biological chemistry 2014 (PubMed)
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More Proteins for C-MYC Interaction Partners

Human V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) interaction partners

The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.
Multivariable analysis indicated that IPI (P = 0.002), chemotherapy regimens (P = 0.017), and MYC gene rearrangements (P = 0.004) were independent adverse prognostic factors for all diffuse large B cell Lymphoma(DLBCL) patients in this study. Results demonstrated that the poor survival of DLBCL patients with HBV infection was closely involved in chemotherapy regimens, IPI, and MYC gene rearrangements
MYC extra copy in diffuse large B-cell lymphoma is an independent poor prognostic factor
The c-Myc/miR (show MLXIP Proteins)-200b/PRDX2 (show PRDX2 Proteins) loop regulates colorectal cancer (CRC (show CALR Proteins)) progression and its disruption enhances tumor metastasis and chemotherapeutic resistance in CRC (show CALR Proteins).
We found that the combination of alpha-mangostin with TRAIL induced apoptosis of SAS (show TSPAN31 Proteins) cells through the mitochondrial pathway via activation of caspase-9 (show CASP9 Proteins) and -3/7, following release of cytochrome c (show CYCS Proteins). This apoptosis was induced by S/G2 (show STRN3 Proteins)/M-phase arrest. Immunopositivity for c-Myc was observed in the cytoplasm of tumor cells in 16 (40%) of the 40 cases of human oral squamous cell carcinoma (HOSCC).
current data demonstrate that both INSR (show INSR Proteins) and IGF1R (show IGF1R Proteins) are directly targeted by C-myc and exert similar effects to promote the tumorigenesis and metastasis of TSCC through the NF-kappaB (show NFKB1 Proteins) pathway.
clusters of enhancers, such as BENC in the MYC gene, form highly combinatorial systems that allow precise control of gene expression across normal cellular hierarchies and which also can be hijacked in malignancies
This study elucidates the molecular basis of the c-Myc/EGLN1 (show EGLN1 Proteins)-mediated induction of LSH (show HELLS Proteins) expression that inhibits ferroptosis
the findings outlined in the current study suggest that PCAT-1 regulates the invasiveness and drug resistance in CRC (show CALR Proteins) cells and that PCAT-1 may promote CRC (show CALR Proteins) cell invasion by modulating the expression of c-Myc.
data show that Hdac1 (show HDAC1 Proteins) and Hdac2 (show HDAC2 Proteins) impact on Emu-myc B cell proliferation and apoptosis and suggest that a critical level of Hdac (show HDAC3 Proteins) activity may be required for Emu-myc tumorigenesis and proper B cell development

Cow (Bovine) V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) interaction partners

Ouabain-induced proliferation might be attributed, at least in part, to decrease of intracellular free calcium and increase of c-myc mRNA expression, and that may be directly or indirectly involved in regulation of blood pressure.

Rabbit V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) interaction partners

report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development

Mouse (Murine) V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) interaction partners

Although mnt heterozygosity clearly slowed lymphomagenesis in vavP-MYC10 and Emu-myc mice, the change(s) in cellular properties responsible for this effect remain to be identified.
clusters of enhancers, such as BENC in the myc gene, form highly combinatorial systems that allow precise control of gene expression across normal cellular hierarchies and which also can be hijacked in malignancies
Conditional deletion of Myc in hyaloid vascular endothelial cells suppressed both proliferation and cell death.
c-Myc repression during development is crucial for the maturation of preacinar cells, and c-Myc overexpression can contribute to pancreatic carcinogenesis through the induction of a dedifferentiated state.
MYC negatively regulated the expression of genes involved in mitochondrial biogenesis and maintenance but positively regulated genes involved in DNA and histone methylation. Knockdown of MYC in colorectal cancer cells reset the altered metabolism and suppressed cell growth.
High myc expression is associated with Intestinal Tumorigenesis.
results shed light on how overexpressed MYC alters the various phases of the RNAPII cycle and the resulting transcriptional response.
c-Myc overexpression stimulated proliferation and activation of renal fibroblasts by inducing integrin alphav-mediated TGF-beta (show TGFB1 Proteins) signaling.
In the Myc-induced liver tumor model in zebrafish, a dramatic increase of liver size with neoplastic features was observed, as well as enhanced angiogenesis, and increase liver-infiltrated neutrophils and hypoxia. This model provides an excellent platform for study of tumor microenvironment.
Using inducible genetic mosaics, we overexpressed Myc in the epicardium and determined the differential expansion of Myc-overexpressing cells with respect to their wild type counterparts. Myc-overexpressing cells overcolonized all epicardial-derived lineages and showed increased ability to invade the myocardium and populate the vasculature.

Zebrafish V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) interaction partners

Methylparabens exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group.
Apoptosis was also observed with myca expression; introduction of homozygous tp53 (show TP53 Proteins)(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.
MYC down-regulation induces mitochondrial apoptosis in T lymphoblasts.

Xenopus laevis V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) interaction partners

These findings not only reveal a novel role of Mad1 (show MXD1 Proteins) in regulating developmental cell death but also suggest that a balance of Mad and Myc controls cell fate determination during adult organ development.
Thyroid hormone (show PTH Proteins) activates protein arginine methyltransferase 1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development.(
c-Myc has a direct role in the control of DNA replication
Findings support a model in which Myc, Twist and Slug/Snail2 function in a regulatory circuit within lateral plate mesoderm that directs normal vessel formation in both the vascular and lymphatic systems.

Fruit Fly (Drosophila melanogaster) V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) interaction partners

Expression of Drosophila Myc (dMyc) suppresses, whereas loss of dMyc enhances, ectopically activated JNK (show MAPK8 Proteins) signaling-induced cell death. dMyc impedes physiologically activated JNK (show MAPK8 Proteins) pathway-mediated cell death. Loss of dMyc triggers JNK (show MAPK8 Proteins) pathway activation and JNK (show MAPK8 Proteins)-dependent cell death.
tissue-specific downregulation of the Drosophila homolog of human c-myc proto-oncogene (dMyc) suppresses tau-mediated morphological and functional deficits by reducing abnormal tau hyperphosphorylation and restoring the heterochromatin loss.
dMyc has an essential role in preventing JNK (show MAPK8 Proteins)-mediated retinal glial activation
the key target of the Psi/MED network in controlling developmentally regulated tissue growth is the transcription factor MYC.
Myc dosage plays crucial role in determining sex-specific size in Drosophila larvae and adult tissue. Double dose of Myc in females serves at least twice in development to promote sexual size dimorphism.
BicC (show BICC1 Proteins) down regulates Myc in the Malpighian tubule.
activation of the TOR-Myc axis in midgut stem and progenitor cells influences a variety of traits in Drosophila
Drosophila adult muscle precursors display homing behavior to muscle niche and the niche-driven Insulin (show INS Proteins)-Notch (show NOTCH1 Proteins)-dMyc cascade plays a key role in setting the activated state of adult muscle precursors.
a functional link between Myc, a renowned oncogene (show RAB1A Proteins), and the essential nucleotide biosynthetic enzyme CTPsyn.
MYC and S6K (show RPS6KB1 Proteins) cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A (show RRN3 Proteins).

C-MYC (MYC) Protein Profile

Protein Summary

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Alternative names and synonyms associated with C-MYC (MYC)

MYC proto-oncogene, bHLH transcription factor (MYC)
v-myc myelocytomatosis viral oncogene homolog (LOC100136746)
MYC proto-oncogene, bHLH transcription factor (Myc)
myelocytomatosis oncogene (Myc)
MYC proto-oncogene, bHLH transcription factor a (myca)
MYC proto-oncogene, bHLH transcription factor L homeolog (myc.L)
v-myc myelocytomatosis viral oncogene homolog (avian) (MYC)
CG10798 gene product from transcript CG10798-RB (Myc)

anon-WO03040301.171 protein
AU016757 protein
bHLHe39 protein
bHLHe57 protein
c-MYC protein
c-myc II protein
CG10798 protein
CMyc protein
d-myc protein
da protein
dm protein
dm/dMyc protein
dm/myc protein
Dmel\CG10798 protein
dmyc protein
dmyc1 protein
EG:BACN5I9.1 protein
l(1)G0139 protein
l(1)G0354 protein
l(1)G0359 protein
LOC100136746 protein
mMyc protein
MRTL protein
myc protein
myc-B protein
myc2 protein
MYCC protein
Niard protein
Nird protein
RNCMYC protein
zc-myc protein

Protein level used designations for MYC

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , avian myelocytomatosis viral oncogene homolog class E basic helix-loop-helix protein 39 myc proto-oncogene protein myc-related translation/localization regulatory factor proto-oncogene c-Myc transcription factor p64 v-myc myelocytomatosis viral oncogene homolog c-myc proto-oncogene avian myelocytomatosis viral (v-myc) oncogene homolog c-Myc Avian myelocytomatosis viral (v-myc) oncogene homolog myelocytomatosis viral oncogene homolog v-myc avian myelocytomatosis viral oncogene homolog cellular myelocytomatosis oncogene Proto-oncogene c-Myc Transcription factor p64 C-Myc1 c-Myc-A cmyca transcriptional regulator Myc-A MYC II transcriptional regulator Myc-B Myc proto-oncogene protein CG10798 gene product from transcript CG10798-RB CG10798-PA CG10798-PB Diminutive protein Myc-PA Myc-PB dMyc1 diminuitive diminutive lethal (1) G0354 lethal (1) G0359

GENE ID	SPECIES
4609	Homo sapiens
464393	Pan troglodytes
403924	Canis lupus familiaris
511077	Bos taurus
448810	Sus scrofa
420332	Gallus gallus
100327265	Oryctolagus cuniculus
100136746	Oncorhynchus mykiss
24577	Rattus norvegicus
443447	Ovis aries
17869	Mus musculus
694626	Macaca mulatta
100379628	Felis catus
30686	Danio rerio
399315	Xenopus laevis
100407754	Callithrix jacchus
100972175	Pan paniscus
100724557	Cavia porcellus
31310	Drosophila melanogaster

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Show all V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) Proteins (MYC) with Pubmed References