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Human C-MYC Protein expressed in HEK-293 Cells - ABIN2715370
Garcia-Sanz, Quintanilla, Lafita, Moreno-Bueno, García-Gutierrez, Tabor, Varela, Shiio, Larsson, Portillo, Leon: Sin3b interacts with Myc and decreases Myc levels. in The Journal of biological chemistry 2014
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This study reveals a stringent association between FGFR (show FGFR2 Proteins) and the downstream effector c-Myc in FGFR (show FGFR2 Proteins)-dependent cancers, and suggests the potential therapeutic value of c-Myc in FGFR (show FGFR2 Proteins)-targeted cancer therapy.
ROCK inhibitor Y-27632 cooperated with Myc to immortalize keratinocytes efficiently, indicating that apoptosis is a major barrier to Myc-induced immortalization of keratinocytes.
we uncovered pathogenic MYC mutations that appear restricted to acute myeloid leukemias with NUP98-NSD1 translocations
modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 (show RPS6KB1 Proteins) and MYC activity
Further analysis indicated that JQ1 inhibited the recruitment of BDR4 to the promoter complex of the Myc and Ccnd1 (show CCND1 Proteins) genes in rat thyroid follicular PCCL3 cells, resulting in decreased MYC expression at the mRNA and protein levels to inhibit tumor cell proliferation
Data show that inhibition of sphingosine kinase-2 (show SPHK2 Proteins) by ABC294640 is synergistically cytotoxic with gemcitabine toward three pancreatic cancer cell lines, resulting in decreased expression of both ribonucleotide reductase regulatory subunit M2 (RRM2 (show RRM2 Proteins)) and c-MYC protein (Myc) in all three cell lines.
Data show that tripartite motif-containing protein 33 (TRIM33 (show TRIM33 Proteins)) silencing attenuates down-regulation of MYC and TGF-beta (show TGFB1 Proteins) signaling in response to bromodomain and extraterminal domain protein inhibitors (BETi).
C-MYC is related to GATA3 (show GATA3 Proteins) and Ki-67 (show MKI67 Proteins) expression and associated with poor prognosis in nodal peripheral T-cell lymphomas
Strong cytoplasmic c-myc expression and weak nuclear expression in adrenocortical tumours associated with malignancy and shorter survival.
MYC genetic heteroclonality is a frequent event in diffuse large B-cell lymphoma and may have a relevant role in modulating MYC expression.
Ouabain-induced proliferation might be attributed, at least in part, to decrease of intracellular free calcium and increase of c-myc mRNA expression, and that may be directly or indirectly involved in regulation of blood pressure.
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
High c-myc expression is associated with gliomagenesis.
In a mouse lung model of KRas(G12D)-driven adenomas, co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma.
the role of phosphorylation on AID serine38 in AID activity at the Immunoglobulin switch region and off-target Myc gene, is reported.
This study demonstrates that LMP2A uses the role of MYC in the cell cycle, particularly in the p27(kip1 (show CDKN1B Proteins)) degradation process, to accelerate lymphomagenesis in vivo.
Results show Myc to be dispensable for sustained in vivo hepatocyte proliferation but necessary for maintaining normal lipid homeostasis.
Data show that the induction of BIM (show BCL2L11 Proteins) in the MYC- and RAS-driven leukemia is mediated by the downregulation of miR-17-92, and suggest that induction of BIM (show BCL2L11 Proteins)-mediated apoptosis may be a therapeutic approach for acute lymphoblastic leukemia (ALL).
Pin1 (show PIN1 Proteins) silencing in lymphomas retarded disease progression in mice, making Pin1 (show PIN1 Proteins) an attractive therapeutic target in Myc-driven tumors.
beta-catenin (show CTNNB1 Proteins) cooperates with the transcription factor Myc to activate the progenitor renewal program.
Gfi1 (show ZNF163 Proteins) disruption antagonized the tumor-promoting effects of Ezh2 (show EZH2 Proteins) loss; conversely, Gfi1 (show ZNF163 Proteins) overexpression collaborated with Myc to bypass effects of Trp53 (show TP53 Proteins) inactivation in driving medulloblastoma progression in primary cerebellar neuronal progenitors.
rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, Miz1 (show PIAS2 Proteins), to promote self-renewal. The finding that cMyc operates in a non-canonical manner in the premigratory neural crest highlights the importance of examining its role at specific time points and in an in vivo context.
Apoptosis was also observed with myca expression; introduction of homozygous tp53 (show TP53 Proteins)(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.
MYC down-regulation induces mitochondrial apoptosis in T lymphoblasts.
These findings not only reveal a novel role of Mad1 (show MXD1 Proteins) in regulating developmental cell death but also suggest that a balance of Mad and Myc controls cell fate determination during adult organ development.
Thyroid hormone (show PTH Proteins) activates protein arginine methyltransferase 1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development.(
c-Myc has a direct role in the control of DNA replication
Findings support a model in which Myc, Twist and Slug/Snail2 function in a regulatory circuit within lateral plate mesoderm that directs normal vessel formation in both the vascular and lymphatic systems.
tissue-specific downregulation of the Drosophila homolog of human c-myc proto-oncogene (dMyc) suppresses tau-mediated morphological and functional deficits by reducing abnormal tau hyperphosphorylation and restoring the heterochromatin loss.
dMyc has an essential role in preventing JNK (show MAPK8 Proteins)-mediated retinal glial activation
the key target of the Psi/MED network in controlling developmentally regulated tissue growth is the transcription factor MYC.
Myc dosage plays crucial role in determining sex-specific size in Drosophila larvae and adult tissue. Double dose of Myc in females serves at least twice in development to promote sexual size dimorphism.
BicC (show BICC1 Proteins) down regulates Myc in the Malpighian tubule.
activation of the TOR-Myc axis in midgut stem and progenitor cells influences a variety of traits in Drosophila
Drosophila adult muscle precursors display homing behavior to muscle niche and the niche-driven Insulin (show INS Proteins)-Notch (show NOTCH1 Proteins)-dMyc cascade plays a key role in setting the activated state of adult muscle precursors.
a functional link between Myc, a renowned oncogene (show RAB1A Proteins), and the essential nucleotide biosynthetic enzyme CTPsyn.
MYC and S6K (show RPS6KB1 Proteins) cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A (show RRN3 Proteins).
The data demonstrate that dMYC repression and dMYC-dependent overgrowth in the Hfp hypomorph is further impaired in the C-terminal Hay/XPB (show GTF2H5 Proteins) mutant background.
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
avian myelocytomatosis viral oncogene homolog
, class E basic helix-loop-helix protein 39
, myc proto-oncogene protein
, myc-related translation/localization regulatory factor
, proto-oncogene c-Myc
, transcription factor p64
, v-myc myelocytomatosis viral oncogene homolog
, c-myc proto-oncogene
, avian myelocytomatosis viral (v-myc) oncogene homolog
, Avian myelocytomatosis viral (v-myc) oncogene homolog
, myelocytomatosis viral oncogene homolog
, v-myc avian myelocytomatosis viral oncogene homolog
, cellular myelocytomatosis oncogene
, Proto-oncogene c-Myc
, Transcription factor p64
, transcriptional regulator Myc-A
, MYC II
, transcriptional regulator Myc-B
, Myc proto-oncogene protein
, CG10798 gene product from transcript CG10798-RB
, Diminutive protein
, lethal (1) G0354
, lethal (1) G0359