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anti-Human CHEK1 Antibodies:
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Human Polyclonal CHEK1 Primary Antibody for ICC, IF - ABIN151911
Karnani, Dutta: The effect of the intra-S-phase checkpoint on origins of replication in human cells. in Genes & development 2011
Show all 6 Pubmed References
Human Polyclonal CHEK1 Primary Antibody for IHC - ABIN965885
Zhang, Otterness, Chiang, Xie, Liu, Mercurio, Abraham: Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. in Molecular cell 2005
Show all 4 Pubmed References
Human Polyclonal CHEK1 Primary Antibody for IP, PLA - ABIN151777
Sun, Shieh: Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. in Oncogene 2009
Show all 3 Pubmed References
Human Monoclonal CHEK1 Primary Antibody for WB - ABIN387806
Greenow, Clarke, Jones: Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. in Oncogene 2009
Show all 2 Pubmed References
Human Polyclonal CHEK1 Primary Antibody for IHC - ABIN965886
Clarke, Colantonio, Heslegrave, Rhodes, Links, Conn: Holocaust experience and suicidal ideation in high-risk older adults. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004
Show all 2 Pubmed References
Human Polyclonal CHEK1 Primary Antibody for ELISA, WB - ABIN965881
Sanchez, Wong, Thoma, Richman, Wu, Piwnica-Worms, Elledge: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. in Science (New York, N.Y.) 1997
Show all 2 Pubmed References
Human Monoclonal CHEK1 Primary Antibody for ELISA, WB - ABIN969476
OConnell, Raleigh, Verkade, Nurse: Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. in The EMBO journal 1997
Show all 2 Pubmed References
Human Polyclonal CHEK1 Primary Antibody for IF (p), IHC (p) - ABIN757072
Guo, Cui, Peng, Fang, Zuo, Deng, Wang, Wu, Chen, Deng: Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney. in Oncotarget 2015
Human Monoclonal CHEK1 Primary Antibody for WB - ABIN446614
Chang, Chan, R McGhie, Udugama, Mayne, Collas, Mann, Wong: CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. in Nucleic acids research 2015
Human Polyclonal CHEK1 Primary Antibody for ELISA, ICC - ABIN6260805
Jiang, Wang, Xing, Shen, Lian, Yi, Zhang, Yang, Liu, Zhang: Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro. in Archives of toxicology 2017
Chk1 and 14-3-3 (show YWHAQ Antibodies) proteins cooperate to inactivate the transcriptional repressor functions of atypical E2F (show E2F1 Antibodies) proteins. This mechanism might be of particular importance to cancer cells, since they are exposed frequently to DNA-damaging therapeutic reagents.
Study provides evidence that expression of CHEK1 protein is high in breast tumors arising in Nigerian women and is associated with aggressive cancer phenotypes and is a prognostic marker.
This study reports the crystal structure of the human Chk1 putative kinase-associated 1 (KA1 (show GRIK4 Antibodies)) domain, demonstrating striking structural homology with other sequentially diverse KA1 (show GRIK4 Antibodies) domains. Separately purified Chk1 kinase and KA1 (show GRIK4 Antibodies) domains are intimately associated in solution, which results in inhibition of Chk1 kinase activity.
The nuclear transcription factor Y subunit beta (NFYB (show NFYB Antibodies))-E2F transcription factor 1 (E2F1 (show E2F1 Antibodies)) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC (show CALR Antibodies)) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC (show CALR Antibodies).
Blocking apoptosis alone is insufficient to allow the subsequent outgrowth of primary B cells lacking CHK1 in vivo or B lymphoma lines in vitro, as these cells trigger p53- dependent cell cycle arrest in response to the accumulating DNA damage.
Chk1 and Chk2 (show CHEK2 Antibodies) are significantly expressed in human sperm. In case of sperm DNA damage, up-regulated Chk1 expression may enhance sperm apoptosis and lead to asthenospermia, while increased Chk2 (show CHEK2 Antibodies) expression may inhibit spermatogenesis and result in oligospermia.
CHK1 and CHK2 (show CHEK2 Antibodies) and their activated forms are frequently expressed in HGSC effusions, with higher expression following exposure to chemotherapy, and their expression is related to survival.
expression of AURKA (show AURKA Antibodies) and CHEK1 was linked with detrimental outcome in patients. Our data describe a synthetic lethality interaction between CHEK1 and AURKA (show AURKA Antibodies) inhibitors with potential translation to the clinical setting
DNA alkylation damage leads to ATR (show ANTXR1 Antibodies)-Chk1 activation in cancer cells and ATR (show ANTXR1 Antibodies)-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage.
Expression levels of phosphorylated cdc25A (p-cdc25A) and phosphorylated Chk1 (p-Chk1), belonging to the ATR pathway, were decreased by treatment with Dclk1 inhibitor LRRK2-IN-1 (LRRK), indicating Dclk1 involvement in the ATR pathway
Inhibition of Drf1 (show DBF4B Antibodies) is the primary mechanism by which Chk1 blocks cell-cycle progression in the early embryo and is an essential function of Chk1 at the blastula-to-gastrula stage of development.
The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.
ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.
Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (show CDC45 Antibodies) onto chromatin and thereby serves to antagonize the initiation of replication.
The MRN complex, in particular the nuclease (show DCLRE1C Antibodies) activity of Mre11 (show MRE11A Antibodies), plays an important role in the activation of Chk1 in response to stalled replication forks.
DNA polymerase kappa (show POLK Antibodies)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.
APE2 (show APEX2 Antibodies) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (show APEX2 Antibodies) is essential for Chk1 phosphorylation, indicating a Claspin (show CLSPN Antibodies)-like but distinct role for APE2 (show APEX2 Antibodies) in ATR (show ATR Antibodies)-Chk1 signaling.
Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK (show MAPK8 Antibodies).
Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH Antibodies)(16) by Chk1.
mechanism of Chk1 activation at the DNA replication checkpoint
CHK1 expression levels control the timing of lymphomagenesis
During neurogenesis, cortical neurons became protected from S-phase Chk1 pathway activation by the DNA methyltransferase (show DNMT1 Antibodies) Dnmt1 (show DNMT1 Antibodies), and underwent cell death after S-phase progression.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1/2-controlled DNA-damage response pathways.
Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan (show SUPT6H Antibodies)-nuclear immunostaining pattern of Histone H2AX.
RAD9 (show RAD9A Antibodies) has a prominent role in the ATR (show ATR Antibodies)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
Acute inactivation of E4F1 (show E4F1 Antibodies) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (show ROS1 Antibodies) production, energy stress, and inhibition of de novo pyrimidine synthesis
Altogether, our results classify E4F1 (show E4F1 Antibodies) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.
Heterozygous loss of Chk1 in a Wnt (show WNT2 Antibodies)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.
PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity
ATM (show ATM Antibodies) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.
The Chk1 directly phosphorylates eNOS (show NOS3 Antibodies) Ser (show SIGLEC1 Antibodies)(1179) in response to UV irradiation, which is dependent on Hsp90 (show HSP90 Antibodies) interaction.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
CHK1 checkpoint homolog
, Serine/threonine-protein kinase Chk1-like protein
, serine/threonine-protein kinase Chk1
, serine/threonine-protein kinase chk1
, Checkpoint, S. pombe, homolog of, 1
, cell cycle checkpoint kinase
, checkpoint kinase-1
, Chk1 checkpoint kinase
, checkpoint kinase 1 homolog
, rad27 homolog
, integral membrane protein 1