CHEK2 Proteins

12 Checkpoint Kinase 2 (CHEK2) Proteins from 6 manufacturers are available on www.antibodies-online.com.

Data Quality
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Type
  • 12
    Protein
Antigen
  • 12
Reactivity
  • 10
  • 2
Application
  • 6
  • 5
  • 4
  • 4
  • 2
Host
  • 4
  • 3
  • 2
  • 2
  • 1
Binding Specificity
  • 3
  • 2
  • 1
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Conjugate
  • 2
  • 5
  • 3
  • 1
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Protein Type
  • 12
Format
  • 6
  • 1
Biological Activity
  • 4
12 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3091285
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3137621
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1349305
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Insect Cells (Source)
ReactivityHuman
Application Func, SDS
Order details Cat. No. ABIN5570206
$478.67
5 μg
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2713979
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, Insect cells (Sf9) (Source)
ReactivityHuman
Order details Cat. No. ABIN2128528
$540.71
5 μg
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
Recombinant Protein, Baculovirus infected Insect Cells (Source), Purity SDS-PAGE: ≥90 %
ReactivityHuman
Application Func, SDS, WB
Order details Cat. No. ABIN411919
$295.00
5 μg
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1349307
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Baculovirus infected Insect Cells (Source), Purity > 95 % as determined by SDS-PAGE.
ReactivityHuman
Application SDS
Order details Cat. No. ABIN5499790
$427.77
Plus shipping costs $45.00
Delivery in 14 to 16 Business Days
Recombinant Protein, Insect Cells (Source), Purity 70 % - 90 %
ReactivityHuman
Application Func
Order details Cat. No. ABIN5508871
$340.00
10 μg
Plus shipping costs $45.00
Delivery in 3 to 4 Business Days
Recombinant Protein, Baculovirus infected Insect Cells (Source), Purity > 90 % as determined by SDS-PAGE
ReactivityMouse (Murine)
Application SDS
Order details Cat. No. ABIN2007792
ISO
$388.88
Plus shipping costs $45.00
Delivery in 14 to 16 Business Days
Recombinant Protein, Insect cells (Sf9) (Source)
ReactivityHuman
Order details Cat. No. ABIN5777010
$651.38
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 6 to 7 Business Days
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CHEK2 Protein Profile

Protein Summary

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CHEK2

  • checkpoint kinase 2 (CHEK2) antibody
  • checkpoint kinase 2 (chek2) antibody
  • checkpoint kinase 2 (Chek2) antibody
  • serine/threonine-protein kinase chk2 (MCYG_07308) antibody
  • checkpoint kinase 2 L homeolog (chek2.L) antibody
  • cds1 antibody
  • chek2 antibody
  • chk2 antibody
  • fa66f08 antibody
  • hCds1 antibody
  • hucds1 antibody
  • lfs2 antibody
  • pp1425 antibody
  • rad53 antibody
  • wu:fa66f08 antibody
  • zgc:55865 antibody

Protein level used designations for Checkpoint Kinase 2 Proteins (CHEK2)

CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , protein kinase CHK2 , checkpoint and tumor suppressor protein 2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2 , CHK2 checkpoint homolog (S. pombe) , serine/threonine-protein kinase Chk2-like , serine/threonine-protein kinase chk2 , checkpoint kinase 2 L homeolog , protein kinase Cds1

GENE ID SPECIES
11200 Homo sapiens
486338 Canis lupus familiaris
458733 Pan troglodytes
100192447 Sus scrofa
336998 Danio rerio
768913 Gallus gallus
50883 Mus musculus
114212 Rattus norvegicus
100059288 Equus caballus
100404949 Callithrix jacchus
100467146 Ailuropoda melanoleuca
100594542 Nomascus leucogenys
9226831 Arthroderma otae CBS 113480
398179 Xenopus laevis