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Therefore, the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
By ubiquitylating and degrading NOXA through activating CRL5, UBE2F (show UBE2F Proteins) selectively promotes lung cancer cell survival and could, therefore, serve as a novel cancer target
Data show that Noxa-mediated MCL-1 (show MCL1 Proteins) phosphorylation and degradation is regulated by CDK2 (show CDK2 Proteins).
the c-FLIP (show CFLAR Proteins) and NOXA/Mcl-1 (show MCL1 Proteins) axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells
Noxa is involved in X-ray-induced lung injury.
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and acts synergistically with antimicrotubule drugs.
knockdown of MCL-1 (show MCL1 Proteins) in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells
high levels of miR21 expression may induce gastric cancer migration and invasion via the downregulation of Noxa expression
Inhibition of SIRT1 (show SIRT1 Proteins) could induce the Noxa expression in A549/DDP (show TIMM8A Proteins) cells.
Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA and BIM (show BCL2L11 Proteins) upregulation.
Noxa demethylation has a role in Bortezomib resistance in mantle cell lymphoma
knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
In vivo upregulation of noxa was reduced by pifithrin-alpha, suggesting transcription may be partly p53 (show TP53 Proteins)-dependent.The present findings indicate Noxa does not serve as a proapoptotic BH3-only protein (show BAD Proteins) during seizure-induced neuronal death in vivo
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2 (show SALL2 Proteins)/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Our data demonstrate that ES cells are uniquely sensitive to CDK1 (show CDK1 Proteins) inhibition via a p53 (show TP53 Proteins)/NOXA/MCL1 (show MCL1 Proteins) pathway.
Overall, these data reveal a Noxa-mediated signaling pathway that couples lysosomal membrane permeabilization with mitochondrial outer membrane permeabilization and ultimate apoptosis during oxidative stress.
by preventing the consumption of IL-15 (show IL15 Proteins), Bim (show BCL2L11 Proteins) limits the role of Noxa and Puma (show BBC3 Proteins) in causing the death of effector cells with less memory potential.
Induction of noxa does not influence ischemic neuronal injury.
the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
phorbol-12-myristate-13-acetate-induced protein 1
, PMA-induced protein 1
, adult T cell leukemia-derived PMA-responsive
, immediate-early-response protein APR
, protein Noxa