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anti-Human p300 Antibodies:
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Human Monoclonal p300 Primary Antibody for ChIP, EM - ABIN152047
Eckner, Ludlow, Lill, Oldread, Arany, Modjtahedi, DeCaprio, Livingston, Morgan: Association of p300 and CBP with simian virus 40 large T antigen. in Molecular and cellular biology 1996
Show all 9 Pubmed References
Human Monoclonal p300 Primary Antibody for FACS, ICC - ABIN151948
Eckner, Yao, Oldread, Livingston: Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. in Genes & development 1996
Show all 6 Pubmed References
Human Polyclonal p300 Primary Antibody for DB - ABIN1881299
Zhang, Zhang, Rui, Liu: p300-mediated acetylation stabilizes the Th-inducing POK factor. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 5 Pubmed References
Human Polyclonal p300 Primary Antibody for ChIP, ICC - ABIN152981
Julien, Carriere, Moreau, Roux: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. in Molecular and cellular biology 2010
Show all 4 Pubmed References
Human Monoclonal p300 Primary Antibody for ChIP, ICC - ABIN152048
Eckner, Ewen, Newsome, Gerdes, DeCaprio, Lawrence, Livingston: Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. in Genes & development 1994
Show all 4 Pubmed References
Human Monoclonal p300 Primary Antibody for ChIPSeq, ChIP - ABIN2668569
Dallas, Yaciuk, Moran: Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. in Journal of virology 1997
Show all 3 Pubmed References
Human Monoclonal p300 Primary Antibody for ELISA, WB - ABIN969098
Stauffer, Chang, Huang, Dunn, Thayer: p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. in The Journal of biological chemistry 2007
Show all 2 Pubmed References
Human Monoclonal p300 Primary Antibody for ELISA, WB - ABIN966068
Geiger, Sharma, Kim, Nyborg: The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. in Molecular and cellular biology 2008
Show all 2 Pubmed References
Human Monoclonal p300 Primary Antibody for IF, IHC (p) - ABIN560748
Wong, Pickard, McCance: p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1). in PLoS ONE 2010
Human Polyclonal p300 Primary Antibody for DB, IHC (p) - ABIN389698
Aubry, Shin, Crary, Lefort, Qureshi, Lefebvre, Califano, Shelanski: Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression. in PLoS ONE 2015
p300 autoacetylation is associated with tongue neoplasms.
CREBBP (show CREBBP Antibodies) and p300 may contribute to genome stability by fine-tuning the functions of DNA damage signaling and DNA repair factors, thereby expanding their role as tumor suppressors. (Review)
Results show that p300 recruitment along with binding to histones are required for cMyb (show MYB Antibodies) to fully activate transcription of a chromatinembedded gene.
Our data show that the hyperacetylation of Tau by p300 histone acetyltransferase (HAT (show HAT Antibodies)) disfavors liquid-liquid phase separation , inhibits heparin-induced aggregation, and impedes access to LLPS-initiated microtubule assembly
EP300 variants are associated with Rubinstein-Taybi syndrome.
High P300 expression is associated with recurrence in prostate cancer.
Data generated with primary human hepatic stellate cells (HSC) supports that stiffness-mediated HSC activation requires p300.
The histone acylation activity of p300 can be activated by pre-existing lysine crotonylation through a positive feedback mechanism.
epigenomic profiling of clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC) establishes a compendium of somatically altered cis (show CISH Antibodies)-regulatory elements, uncovering new potential targets including ZNF395 (show ZNF395 Antibodies). Loss of VHL (show VHL Antibodies), a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a (show EPAS1 Antibodies) and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes
Histone acetyltransferase (show HAT Antibodies) EP300 is necessary for the transcription factor SOX2 (show SOX2 Antibodies) activity in basal cells, including for induction of the squamous fate. EP300 copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines.
Study in mouse model found that liver stiffness activates hepatic stellate cells differentiation into myofibroblasts, which required nuclear accumulation of p300 (show NOTCH1 Antibodies).
Data (including data from studies in knockout and transgenic mice) suggest that Ep300 and Crebbp (show CREBBP Antibodies) are limiting cofactors for pancreatic islet development (including gene expression regulation and cell proliferation), and hence for postnatal glucose homeostasis, with some functional redundancy. (Ep300 = E1A binding protein p300; Crebbp (show CREBBP Antibodies) = CREB binding protein (show CREBBP Antibodies))
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP (show NFAT5 Antibodies) is required for the recruitment of p300 (show NOTCH1 Antibodies). Increased expression of TonEBP (show NFAT5 Antibodies) enhances the NFkappaB activity and reduced TonEBP (show NFAT5 Antibodies) expression lowers it.
Enhancer-priming by MLL3/MLL4 (show MLL4 Antibodies) followed by enhancer-activation by CBP/p300 (show CREBBP Antibodies) sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS (show TLR4 Antibodies) induces endoplasmic reticulum (ER) stress and P300 (show NOTCH1 Antibodies) activity via the XBP1 (show XBP1 Antibodies)/IRE1 (show ERN1 Antibodies) pathway.
Loss of p300 (show NOTCH1 Antibodies) expression is associated with leukemogenesis.
UTX (show KDM6A Antibodies)-MLL4 (show MLL4 Antibodies)-p300 (show NOTCH1 Antibodies) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (show CREBBP Antibodies) and HDAC1-HDAC2 (show HDAC1 Antibodies) has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (show PRMT1 Antibodies) activity was necessary for c-Myc (show MYC Antibodies) binding to acetyltransferase p300 (show NOTCH1 Antibodies) in myeloid cells; Prmt1 (show PRMT1 Antibodies) inhibition decreases p300 (show NOTCH1 Antibodies) recruitment to c-Myc (show MYC Antibodies) target promoters and increased Hdac1 (show HDAC1 Antibodies) recruitment. [Prmt1 (show PRMT1 Antibodies), protein arginine N-methyltransferase 1 (show PRMT1 Antibodies); c-Myc (show MYC Antibodies) = Proto-Oncogene (show RAB1A Antibodies) Proteins c-myc (show MYC Antibodies); Hdac1 (show HDAC1 Antibodies) = histone deacetylase 1 (show HDAC1 Antibodies)]
In line with the acetyltransferase activity of p300 (show NOTCH1 Antibodies), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Antibodies) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Antibodies) to its gene
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT