Browse our anti-p53 (TP53) Antibodies

Human Tumor Protein P53 (TP53) interaction partners

1. Differentiation-dependent downregulation of p53 is a prerequisite for activating autophagy in the syncytiotrophoblast.

2. Significant increase in frequencies ofTP53 (rs1042522 G/C), BRCA1 (rs71361504 -/GTT, rs3092986T/C) genotypes and alleles in polycystic ovary patients compared to controls.

3. p53 expression showed a statistically significant impact on renal cell carcinoma (show MOK Antibodies) disease progression , albeit not on cancer-specific mortality.

4. Deletion of NF1 (show NF1 Antibodies) leads to mutant oligodendrocyte precursor cell (OPC) expansion through increased proliferation and decreased differentiation, the deletion of p53 impairs OPC senescence. Signaling analysis showed that, while PI3K (show PIK3CA Antibodies) and MEK (show MAP2K1 Antibodies) pathways go through stepwise over-activation, mTOR (show FRAP1 Antibodies) signaling remains at the basal level in pre-transforming mutant OPCs but is abruptly up-regulated in tumor OPCs.

5. Study discovered that a p53-dependent tumor-suppressor (TS) network triggered by nucleolar stress is tuned by miR (show MLXIP Antibodies)-101. Activation of this network, the p53-miR (show MLXIP Antibodies)-101 circuit, enables induction of apoptosis in p53 WT cancer cells by G2 phase-specific positive-feedback regulation of p53 mediated by direct repression of EG5 (show KIF11 Antibodies).

6. In silico molecular docking and dynamics studies with MDM2 (show MDM2 Antibodies)-p53 protein revealed that HTMF was more potent compound that could inhibit the binding of MDM2 (show MDM2 Antibodies) with p53 and, therefore, could trigger apoptosis in cancer cell.

7. Expression of Ki-67 (show MKI67 Antibodies) was lower and expression of p53 was higher in primary tumors than in ascitic cells

8. This review outlines the roles of important E3(Ub)-ligases and their splice variants in maintaining cellular p53 protein homeostasis. [review]

9. This result suggests that p53 has an important role in hemangioma endothelial cell (HemEC) apoptosis. The results of the present study additionally suggest that the propranololinduced HemEC apoptosis pathway is a mitochondrial apoptosis pathway and is regulated by p53BAX signaling.

10. Our findings suggested that RBM38 (show RBM38 Antibodies) may be a core contributor in stabilizing the p53-mdm2 (show MDM2 Antibodies) loop function to prevent hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and a potential novel target to provide a therapeutic strategy for HCC (show FAM126A Antibodies) by inhibiting mdm2 (show MDM2 Antibodies) and rescuing p53 from inactivation.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

1. Inhibition of p53 signaling pathway can reverse the cell cycle arrest in G0/G1 phase induced by Porcine epidemic diarrhea virus infection.

2. in a pig model of human familial adenomatous polyposis, p53 plays a role in the early precancerous stages of polyp development

3. Knockdown of p53 led to three outcomes: 1) cell death was attenuated; 2) Tunicamycin-induced redistribution of GRP78 (show HSPA5 Antibodies) from the nucleus to the endoplasmic reticulum lumen was recovered; and 3) the endoplasmic reticulum-fluorescence/EGFP-calreticulin (show CALR Antibodies) was recovered.

4. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

5. SIRT1 (show SIRT1 Antibodies), p53 and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

6. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

7. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Antibodies)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Antibodies)).

8. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Antibodies) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

9. role of transcription factor p53 and the metabolic hormone leptin (show LEP Antibodies), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

10. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

Rabbit Tumor Protein P53 (TP53) interaction partners

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (show MAPK14 Antibodies) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Antibodies) plays a role by way of stimulating NF-kappaB (show NFKB1 Antibodies), p53 and caspase-3 (show CASP3 Antibodies) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Antibodies) proteins.

4. Chronically activated, monomeric PDGFRA (show PDGFRA Antibodies) induced prolonged activation of Akt (show AKT1 Antibodies) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) interaction partners

1. Nkx2.5 signaling via activation of Nkx2.5-Calr (show CALR Antibodies)-p53 signaling pathway results in cardiac dysfunction and hyperglycemia-induced cardiomyopathy.

2. In the hsf4 (show HSF4 Antibodies)(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas (show FASN Antibodies) and bax (show BAX Antibodies) mRNA into the mutant embryos, we directly proved that HSF4 (show HSF4 Antibodies) promotes lens fiber cell differentiation by activating p53 and its downstream regulators

3. p53-target genes in Danio rerio have been identified.

4. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

5. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

6. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

7. results suggest that trim69 (show TRIM69 Antibodies) participates in tp53-mediated apoptosis during zebrafish development.

8. mutant Mdm2 (show MDM2 Antibodies) was unable to rescue a p53-induced apoptotic phenotype.

9. C/ebpalpha (show CEBPA Antibodies) plays a role in liver growth regulation via the p53 pathway.

10. Results demonstrate a novel role of Klf8 (show KLF8 Antibodies), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A (show DNMT3A Antibodies) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (show AKT1 Antibodies) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

1. Deletion of NF1 (show NF1 Antibodies) leads to mutant oligodendrocyte precursor cell (OPC) expansion through increased proliferation and decreased differentiation, the deletion of p53 impairs OPC senescence. Signaling analysis showed that, while PI3K and MEK (show MDK Antibodies) pathways go through stepwise over-activation, mTOR (show FRAP1 Antibodies) signaling remains at the basal level in pre-transforming mutant OPCs but is abruptly up-regulated in tumor OPCs.

2. findings uncover a new function of p53 in the regulation of Akt (show AKT1 Antibodies) signaling and reveal how p53, ASS1 (show ASS1 Antibodies), and Akt (show AKT1 Antibodies) are interrelated to each other.

3. Rlip deficiency suppresses spontaneous malignancy in p53(-/-) mice.

4. Obtained results suggest that Wip1 (show PPM1D Antibodies) deficiency sensitizes cells to sodium butyrate and to MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) inhibitors independently from Wip1 (show PPM1D Antibodies) main target protein - p53. Data acquired give insights into role of Wip1 (show PPM1D Antibodies) in cellular responses to treatment with HDAC (show HDAC3 Antibodies) and MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) inhibitors.

5. CYLD removes K48-linked ubiquitin chains from p53 indirectly by cleaving K63 chains, suggesting that p53 is decorated with complex ubiquitin chains.

6. tumor suppressor p53 functions as an essential antiviral molecule against Japanese encephalitis virus

7. Results show that p53 expression and mutational status do not interfere with CES2 expression in colorectal neoplasm.

8. the beta-catenin (show CTNNB1 Antibodies) C-terminus indirectly represses p53, and this function is essential for embryogenesis.

9. Results suggest that the chronic inflammation due to constitutive overexpression of TNF (show TNF Antibodies) is not sufficient to significantly accelerate tumorigenesis driven by the loss of p53.

10. the MDM2 (show MDM2 Antibodies)-p53-PC signalling axis links mitochondrial metabolism to insulin (show INS Antibodies) secretion and glucose homeostasis, and could represent a therapeutic target in diabetes.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Antibodies), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

1. Expression of p53 and Ki67 (show MKI67 Antibodies) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) interaction partners

1. miR (show MYLIP Antibodies)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) interaction partners

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.