Browse our anti-p53 (TP53) Antibodies

Human Tumor Protein P53 (TP53) interaction partners

1. Low TP53 expression is associated with clear cell and endometrioid carcinoma of the ovary and the endometrium.

2. Tumor suppressor p53 protein mutation from lung carcinoma patients stimulates cell spreading and migration. Mutant p53 (R175H) decrease the expression of Rho GTPase activating protein 44 (show ARHGAP44 Antibodies) in both mRNA and protein level.

3. On the contrary, BMP7 (show BMP7 Antibodies) specific antibody inhibits the HNK-induced activation of p53 in colon cancer cells and partly decreases the total level of p53. Our findings suggested that HNK may be a promising anticancer drug for CRC (show CALR Antibodies); activation of p53 plays an important role in the anticancer activity of HNK, which may be initialized partly by the HNK-induced upregulation of BMP7 (show BMP7 Antibodies).

4. that COP1 (show CARD16 Antibodies) may play a role in promoting glioma cell proliferation by interacting with and downregulating tumor suppressor p53 rather than oncogenic protein c (show PROC Antibodies)-JUN (show JUN Antibodies)

5. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53-dependent apoptosis (PUMA (show BBC3 Antibodies)) and autophagy (DRAM (show DRAM1 Antibodies)) gene occurred, modifying the ADR (show AKR1B1 Antibodies)-induced cancer cell death in HG both in vitro and in vivo.

6. p53 in cytoplasm improves the accuracy of DNA synthesis of HIV-1 reverse transcriptase by removal of the non-canonical dU from the nascent DNA.

7. Inhibition of the remaining family member FXR1 (show FXR1 Antibodies) selectively blocks cell proliferation in human cancer cells containing homozygous deletion of both TP53 and FXR2 (show FXR2 Antibodies) in a collateral lethality manner.

8. miR612 is identified as associated with esophageal squamous cell carcinoma development and metastasis, likely through the regulation of TP53 expression.

9. Low TP53 expression is associated with non-small-cell lung cancer.

10. These data suggested that Annexin A2 (show ANXA2 Antibodies) induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 signaling, and provided an evidence that blockade of Annexin A2 (show ANXA2 Antibodies) could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

2. SIRT1 (show SIRT1 Antibodies), p53 and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

4. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Antibodies)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Antibodies)).

5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Antibodies) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

6. role of transcription factor p53 and the metabolic hormone leptin (show LEP Antibodies), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Antibodies) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

9. Suppressive effect of FSH (show BRD2 Antibodies) and LH on p53 expression and caspase-3 (show CASP3 Antibodies) activity with parallel increase in bcl-2 (show BCL2 Antibodies) expression and increased P production was observed.

10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (show MAPK14 Antibodies) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Antibodies) plays a role by way of stimulating NF-kappaB (show NFKB1 Antibodies), p53 and caspase-3 (show CASP3 Antibodies) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Antibodies) proteins.

4. Chronically activated, monomeric PDGFRA (show PDGFRA Antibodies) induced prolonged activation of Akt (show AKT1 Antibodies) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) interaction partners

1. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

2. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

3. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

4. results suggest that trim69 (show TRIM69 Antibodies) participates in tp53-mediated apoptosis during zebrafish development.

5. mutant Mdm2 (show MDM2 Antibodies) was unable to rescue a p53-induced apoptotic phenotype.

6. C/ebpalpha (show CEBPA Antibodies) plays a role in liver growth regulation via the p53 pathway.

7. Results demonstrate a novel role of Klf8 (show KLF8 Antibodies), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

8. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

9. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (show MDM2 Antibodies) pathway.

10. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A (show DNMT3A Antibodies) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (show AKT1 Antibodies) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

1. These results illustrate the importance of the cooperative activities of p53 and Mdm2 (show MDM2 Antibodies) in a network of miRNAs that function to impose a barrier against aberrant cardiomyocyte cell cycle re-entry to maintain cardiac homeostasis.

2. these observations suggest that hypoxic preconditioning of cardiac progenitor cells could lead to p53 inhibition by up-regulating

3. These data indicate the functional role of the MIF (show MIF Antibodies)-COX (show CPOX Antibodies)-p53 axis in inflammation and cancer at the genomic and proteomic levels in COX-2 (show COX2 Antibodies)-ablated cells.

4. p53 limits ferroptosis of colorectal cancer cells by blocking DPP4 (show DPP4 Antibodies) activity.

5. FGF1 protects neuroblastoma cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation.

6. We used the strategy of haploinsufficiency of Mdm2 (show MDM2 Antibodies) and Mdm4 (show MDM4 Antibodies) to induce mild p53 activation in vivo and found that Mdm2 (show MDM2 Antibodies)(+/-)Mdm4 (show MDM4 Antibodies)(+/-) double-heterozygous mice exhibited normal embryogenesis. However, closer examination demonstrated that the Mdm2 (show MDM2 Antibodies)(+/-)Mdm4 (show MDM4 Antibodies)(+/-) cells exhibited a growth disadvantage and were outcompeted during development in genetic mosaic embryos that contained wild-type cells.

7. The p53 R72P polymorphism did not differentially affect the physiological response to ionizing radiation in mice.

8. c-Abl (show ABL1 Antibodies) phosphorylation of Mdm2 (show MDM2 Antibodies) has a role in regulation of p53 tumor suppression and bone marrow failure

9. Astrocyte-endothelial cell transition could also be modulated by miR (show MLXIP Antibodies)-194, a microRNA downstream of p53 that affects expression of genes regulating angiogenesis.

10. This work documents the important role for p53 in the heart as a master regulator of the cardiac transcriptome.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Antibodies), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

1. Expression of p53 and Ki67 (show MKI67 Antibodies) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) interaction partners

1. miR (show MYLIP Antibodies)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) interaction partners

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.