Browse our anti-p53 (TP53) Antibodies

Human Tumor Protein P53 (TP53) interaction partners

1. results showed that a) alterations of the p53 and Rb pathways are associated with high proliferation of tumor cells in BUC and b) high expression of cell-cycle proteins is associated with adverse histopathological parameters of these tumors

2. Moreover, under positive p53 expression, low expression of ATM[ataxia telangiectasia mutated] was highly predictive of poor survival in ACC[Adenoid cystic carcinoma] (p=0.017). CONCLUSION: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic marker for assessing survival rate in patients with ACC [Adenoid cystic carcinom]of the salivary glands.

3. These results suggest that the wild type p53 plays a role in regulating ZIP14 (show SLC39A14 Antibodies), but not DMT1 (show DMRT1 Antibodies) in HepG2 cells.

4. these results suggested that Aloin may induce apoptosis in A549 cells via the ROSmitogen activated protein kinase (show CDK7 Antibodies) signaling pathway, with p53 phosphorylation. These results implicate Aloin as a potential therapeutic agent for the treatment of lung cancer.

5. Data demonstrates that p53 inhibits OSX (show MID1 Antibodies) binding to their responsive Sp1 (show PSG1 Antibodies)/GC-rich (show RELB Antibodies) sites in the promoters of their osteogenic target genes, such as IBSP (show IBSP Antibodies) or COL1A1 (show COL1A1 Antibodies).

6. A two-hit loss involving VHL (show VHL Antibodies) predicted for clear-cell renal cell carcinoma (show MOK Antibodies)(ccRCC ) and a better prognosis, whereas mutations in PTEN, TP53, or RELN (show RELN Antibodies) predicted for Sarcomatoid clear-cell renal cell carcinoma (show MOK Antibodies) and worse prognosis.

7. Nongenotoxic p53 activation suppresses mTOR (show FRAP1 Antibodies) activity. Moreover, p53 reactivation via RG7388, a second-generation MDM2 (show MDM2 Antibodies) inhibitor, strongly enhances the in vivo antitumor activity of temsirolimus

8. Low TP53 expression is associated with hepatocellular carcinoma.

9. Our results suggest that TP53 may be linked with type 2 diabetes mellitus (T2DM). The fluctuations of serum TP53 level may reflect metabolic and oxidative stress associated with chronic hyperglycaemia

10. Vorinostat synergizes with AZD1775 in head and neck squamous cell carcinoma (HNSCC)cells with mutant p53 in vitro and in vivo A strategy combining HDAC (show HDAC3 Antibodies) and WEE1 (show WEE1 Antibodies) inhibition deserves further clinical investigation in patients with advanced HNSCC.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

2. SIRT1 (show SIRT1 Antibodies), p53 and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

4. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Antibodies)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Antibodies)).

5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Antibodies) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

6. role of transcription factor p53 and the metabolic hormone leptin (show LEP Antibodies), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Antibodies) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

9. Suppressive effect of FSH (show BRD2 Antibodies) and LH on p53 expression and caspase-3 (show CASP3 Antibodies) activity with parallel increase in bcl-2 (show BCL2 Antibodies) expression and increased P production was observed.

10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (show MAPK14 Antibodies) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Antibodies) plays a role by way of stimulating NF-kappaB (show NFKB1 Antibodies), p53 and caspase-3 (show CASP3 Antibodies) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Antibodies) proteins.

4. Chronically activated, monomeric PDGFRA (show PDGFRA Antibodies) induced prolonged activation of Akt (show AKT1 Antibodies) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) interaction partners

1. Nkx2.5 signaling via activation of Nkx2.5-Calr (show CALR Antibodies)-p53 signaling pathway results in cardiac dysfunction and hyperglycemia-induced cardiomyopathy.

2. In the hsf4 (show HSF4 Antibodies)(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas (show FASN Antibodies) and bax (show BAX Antibodies) mRNA into the mutant embryos, we directly proved that HSF4 (show HSF4 Antibodies) promotes lens fiber cell differentiation by activating p53 and its downstream regulators

3. p53-target genes in Danio rerio have been identified.

4. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

5. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

6. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

7. results suggest that trim69 (show TRIM69 Antibodies) participates in tp53-mediated apoptosis during zebrafish development.

8. mutant Mdm2 (show MDM2 Antibodies) was unable to rescue a p53-induced apoptotic phenotype.

9. C/ebpalpha (show CEBPA Antibodies) plays a role in liver growth regulation via the p53 pathway.

10. Results demonstrate a novel role of Klf8 (show KLF8 Antibodies), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A (show DNMT3A Antibodies) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (show AKT1 Antibodies) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

1. Activation of p53 blocks neural differentiation of miRNA-deficient pluripotent stem cells.

2. p53 mediates the regulation of bile acid disposition and attenuates cholic acid-induced cholestasis in mice

3. Data demonstrates that p53 inhibits OSX (show SP7 Antibodies) binding to their responsive Sp1 (show SP1 Antibodies)/GC-rich (show RELB Antibodies) sites in the promoters of their osteogenic target genes, such as IBSP (show IBSP Antibodies) or COL1A1 (show COL1A1 Antibodies).

4. A summary of current knowledge of p53-mediated tumor-suppressive mechanisms gleaned from in vivo studies in mouse models (review).

5. Increased Cdc7 (show CDC7 Antibodies)-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma.

6. Aging mouse models have revealed the complexity of the p53-Mdm2 (show MDM2 Antibodies) axis and have solidly placed the p53 network as being key to many aspects of both pathological aging conditions and normal aging (review).

7. In myoblasts silenced for the expression of muscle regulatory transcription factor MyoD (show MYOD1 Antibodies), tumor suppressor p53 binding to the PUMA (show BBC3 Antibodies) promoter is diminished in response to culture in differentiation medium.

8. Study provides evidence that high expression of CLDN6 (show CLDN6 Antibodies) confers chemoresistance on breast cancer which is mediated by GSTP1 (show GSTP1 Antibodies), the activity of which is regulated by p53.

9. AKI was associated with the upregulation of several known p53 target genes. This was attenuated in p53-KO mice. In human renal tubular epithelial cell line, vancomycin induced p53 accumulation. p53 was associated with the development of VAN (show SLC11A2 Antibodies)-induced AKI through upregulation of miR (show MLXIP Antibodies)-192-5p.

10. Recent work in a TP53(-/-)BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Antibodies), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

1. Expression of p53 and Ki67 (show MKI67 Antibodies) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) interaction partners

1. miR (show MYLIP Antibodies)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) interaction partners

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.