Browse our anti-p53 (TP53) Antibodies

Human Tumor Protein P53 (TP53) interaction partners

1. The authors showed that homozygote proline/proline in controls was significantly higher compared with that in the patients. They may therefore, conclude that detection of allelic polymorphisms of codon 72 of the p53 gene including arginine/arginine could be a risk factor predisposition for breast cancer and valuable tool for determining prognosis, progress, and treatment purposes.

2. palmitate-induced apoptosis of vascular smooth muscle cell depends on the activation of the pathway involving TLR4 (show TLR4 Antibodies), ROS (show ROS1 Antibodies) and p53

3. Knockdown of CITED2 (show CITED2 Antibodies) led to a decreased interaction of p53 with its inhibitor MDM2 (show MDM2 Antibodies), which results in increased amounts of total p53 protein. Data indicate that CITED2 (show CITED2 Antibodies) functions in pathways regulating p53 activity.

4. Sertad1 (show SERTAD1 Antibodies) could antagonize iASPP (show PPP1R13L Antibodies) function by hindering its entrance into nuclei to interact with P53 in leukemic cells when iASPP (show PPP1R13L Antibodies) was in the stage of overproduction.

5. Among diffuse large B-cell lymphoma (DLBCL)cases, the TP53 mutations shortened both OS and PFS of patients treated with R-CHOP (show DDIT3 Antibodies) (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) and decreased both OS and PFS of patients with secondary DLBCL disease.

6. This study furthers implementation of clinical genomics in MDS (show PAFAH1B1 Antibodies) and identifies TP53 and IDH2 (show IDH2 Antibodies) as targets for pre- or post-transplant therapy

7. Under the same condition, p53 protein expression, but not mRNA expression, was reversed by MG132. Taken together, our data demonstrate that the level of FN expression is associated with the status and expression of p53 in breast cancer cells

8. These results indicate a critical role for p53 in rat germ cell survival and spermatogenesis.

9. In spinal cord tissue, lower PAX3 (show PAX3 Antibodies) expression, higher p53 expression, and increased levels of cleaved caspase 3 (show CASP3 Antibodies)(17kD) and cleaved caspase 8 (show CASP8 Antibodies) (18kD) were found in anencephaly cases but not in spina bifida cases when compared with controls.

10. our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1 (show XRCC1 Antibodies)), apoptosis genes (TP53), as well as of apoptosis inhibition genes (MDM2 (show MDM2 Antibodies)).

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

2. SIRT1 (show SIRT1 Antibodies), p53 and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

4. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Antibodies)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Antibodies)).

5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Antibodies) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

6. role of transcription factor p53 and the metabolic hormone leptin (show LEP Antibodies), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Antibodies) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

9. Suppressive effect of FSH (show BRD2 Antibodies) and LH on p53 expression and caspase-3 (show CASP3 Antibodies) activity with parallel increase in bcl-2 (show BCL2 Antibodies) expression and increased P production was observed.

10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (show MAPK14 Antibodies) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Antibodies) plays a role by way of stimulating NF-kappaB (show NFKB1 Antibodies), p53 and caspase-3 (show CASP3 Antibodies) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Antibodies) proteins.

4. Chronically activated, monomeric PDGFRA (show PDGFRA Antibodies) induced prolonged activation of Akt (show AKT1 Antibodies) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) interaction partners

1. In the hsf4 (show HSF4 Antibodies)(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas (show FASN Antibodies) and bax (show BAX Antibodies) mRNA into the mutant embryos, we directly proved that HSF4 (show HSF4 Antibodies) promotes lens fiber cell differentiation by activating p53 and its downstream regulators

2. p53-target genes in Danio rerio have been identified.

3. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

4. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

5. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

6. results suggest that trim69 (show TRIM69 Antibodies) participates in tp53-mediated apoptosis during zebrafish development.

7. mutant Mdm2 (show MDM2 Antibodies) was unable to rescue a p53-induced apoptotic phenotype.

8. C/ebpalpha (show CEBPA Antibodies) plays a role in liver growth regulation via the p53 pathway.

9. Results demonstrate a novel role of Klf8 (show KLF8 Antibodies), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

10. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A (show DNMT3A Antibodies) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (show AKT1 Antibodies) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

1. Study reports a high-incidence, low-variation spontaneous mouse model of spondyloarthropathy that delineates how the combination of inflammatory cytokine interleukin-27 (IL-27 (show IL27 Antibodies)) signaling deficiency and mitogenic signaling (mutant p53R172H) in vivo, leads to bone loss in the vertebral bodies and ossification of the cartilage in the intervertebral discs.

2. Knockdown of CITED2 (show CITED2 Antibodies) led to a decreased interaction of p53 with its inhibitor MDM2 (show MDM2 Antibodies), which results in increased amounts of total p53 protein. Data indicate that CITED2 (show CITED2 Antibodies) functions in pathways regulating p53 activity.

3. his study demonstrates that inhibition of Drp1 (show CRMP1 Antibodies) hyperactivation by a Drp1 (show CRMP1 Antibodies) peptide inhibitor P110 (show PIK3CA Antibodies) is neuroprotective in a MPTP (show PTPN2 Antibodies) animal model. Our data also suggest that the protective effects of P110 (show PIK3CA Antibodies) treatment might be mediated by inhibiting the p53 mediated apoptotic pathways in neurons through inhibition of Drp1 (show CRMP1 Antibodies)-dependent p53 mitochondrial translocation

4. It has been observed that PTEN expression downregulated by p53 deficiency induced the activation of STAT3 (show STAT3 Antibodies) in autoimmune arthritis.

5. these results indicate that IGF-I (show IGF1 Antibodies) induces senescence of hepatic stellate cells, inactivates these cells and limits fibrosis in a p53-dependent manner and that IGF-I (show IGF1 Antibodies) may be applied to treat nonalcoholic steatohepatitis and cirrhosis.

6. Conditional deletion of uterine Trp53 (p53(d/d)), molecularly linked to mTORC1 activation and causally linked to premature uterine senescence and preterm birth, results in aberrant lipid signatures within the heterogeneous cell types of embryo implantation sites on day 8 of pregnancy.

7. These results suggest that ASPP2 (show TP53BP2 Antibodies) plays an important role in p53-mediated neuronal apoptosis under gp120 (show ITIH4 Antibodies) stress.

8. This study shows that when cell death and cell cycle arrest pathways are inhibited, p53 can still mediate MGMT (show MGMT Antibodies)-dependent repair, to promote cell survival upon DNA damage.

9. DNA repair, mediated by DNA-PK, and cell cycle arrest, mediated by p53, cooperate to protect the stem cell niche after DNA damage.

10. Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Antibodies), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

1. Expression of p53 and Ki67 (show MKI67 Antibodies) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) interaction partners

1. miR (show MYLIP Antibodies)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) interaction partners

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.