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Our results implicate a novel role for Carboxypeptidase E that mainly affects the expression of motility-associated genes via several signal pathways
This study has uncovered a human CPE/NF-alpha1 gene mutation that could lead to comorbidity of dementia and depression, emphasizing the importance of this gene in cognitive function.
CPE through its N'-terminal sequence, forms aggregates with Wnt3a and possible endoplasmic reticulum (ER) stress leading to its loss of function.
we have identified a novel SNP in the CPE gene which results in the loss of its neuroprotective function in cells and may confer neurological disorders in humans
High-level CPE [ carboxypeptidase E] expression was associated with a poor prognosis in early-stage cervical cancer. CPE may serve as a biomarker for predicting PLNM [ pelvic lymph node metastasis ] and survival in these patients.
Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.
Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin and contribute to the formation of cholesterol gallstone.
Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.
Disruption of insulin receptor (IR) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor Eif4g1.
Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.
Data suggest that splice variant of carboxypeptidase E (CPE-DeltaN) that CPE-DeltaN expression might be a potential prognostic marker for colorectal cancer patients.
CPE is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested
CPE forms a complex, probably through sequences located at its N-terminal domain, with Wnt3a and the extracellular cysteine rich domain of Fz1.
Neither high glucose nor insulin (with low glucose) regulates beta-cell CPE (but either up-regulates CPD).
CPE may play a role in promoting tumor growth and invasion.
Carboxypeptidase E is differently expressed in subcutaneous and visceral fat of obese subjects
protein binding with Con A in seminal plasma
cDNA microarray analysis led to the identification of 2 novel biomarkers that should facilitate molecular diagnosis and further study of pulmonary neuroendocrine tumors.
A possible role for mutations in CPE in the development of coronary heart disease.
the severity of the coronary atherosclerosis estimated by Gensini score was significantly influenced by the presence of the A2925G mutant and G2855A mutant of the CPE gene
Cpe knockout leads to dysfunction of BDNF-TRKB signaling in hippocampus and lack of long-term potentiation formation.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP-positive astrocytes for normal neurodevelopment.
we show by RNA silencing that CPE and SgIII play a synergistic role in the trafficking of POMC to granules of the regulated secretory pathway in AtT20 cells
An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.
This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior
The neuroprotective effect of CPE-DeltaN against neuronal glutamate neurotoxicity was mediated by secreted FGF2.
Carboxypeptidase E is an important modulator of RANKL-induced osteoclast differentiation.
Report the effects of ovalbumin sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.
This study has identified CPE as a new neurotrophic factor that can protect neurons against degeneration.
Data suggests that CPE plays critical role in neuroprotection/allostasis in hippocampal neurons during mild chronic stress; up-regulation of CPE and BCL2 (B cell leukemia/lymphoma 2) expression is possibly mediated by glucocorticoids.
There are multiple mechanisms for sorting proglucagon to the regulated secretory pathway, including a role for carboxypeptidase E in pancreatic alpha cells, initial cleavage at K70R71 and multiple sorting signals.
The results, whereby RNAi was used to acutely suppress CPE, do not support a role for this protein as necessary for or central to sorting of POMC/ACTH to the regulated secretory pathway in AtT-20 cells.
Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10]
These results demonstrate that a 25% increase in body weight is sufficient to augment pulmonary responses to O3, but innate AHR is not manifest until the mice become much heavier.
CPE cytoplasmic tail mediates the localization of synaptic vesicles in the actin-rich pre-active zone in hypothalamic neurons and PC12 pheochromocytoma cells.
patients, bearing CPE and cocaine- and amphetamine-regulated transcript mutations leading to inactive forms of these molecules, may be at a higher risk of developing osteoporosis
Our findings suggest that CPE is an important, novel player in mediating appropriate dendritic patterning and spine formation in CNS neurons.
Data suggest that ischemia has an adverse impact on the neuropeptide-processing system in the brain and that the lack of an active carboxypeptidase E neuropeptide-processing enzyme exacerbates ischemic brain injury.
CPE KO mice display a wide range of neural and endocrine abnormalities and suggest that CPE may have additional physiological roles beyond those ascribed to peptide processing and sorting of prohormones in cells.
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
, carboxypeptidase E preproprotein
, carboxypeptidase E-like
, carboxypeptidase H
, cobalt-stimulated chromaffin granule carboxypeptidase
, enkephalin convertase
, insulin granule-associated carboxypeptidase
, prohormone-processing carboxypeptidase