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Our results implicate a novel role for Carboxypeptidase E that mainly affects the expression of motility-associated genes via several signal pathways
This study has uncovered a human CPE/NF-alpha1 gene mutation that could lead to comorbidity of dementia and depression, emphasizing the importance of this gene in cognitive function.
CPE through its N'-terminal sequence, forms aggregates with Wnt3a (show WNT3A Antibodies) and possible endoplasmic reticulum (ER) stress leading to its loss of function.
we have identified a novel SNP in the CPE gene which results in the loss of its neuroprotective function in cells and may confer neurological disorders in humans
High-level CPE [ carboxypeptidase E] expression was associated with a poor prognosis in early-stage cervical cancer. CPE may serve as a biomarker for predicting PLNM [ pelvic lymph node metastasis ] and survival in these patients.
Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.
Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin (show CCK Antibodies) and contribute to the formation of cholesterol gallstone.
Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.
Disruption of insulin receptor (IR (show INSR Antibodies)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (show EIF2A Antibodies) Eif4g1 (show EIF4G1 Antibodies).
Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.
Cpe knockout leads to dysfunction of BDNF (show BDNF Antibodies)-TRKB (show NTRK2 Antibodies) signaling in hippocampus and lack of long-term potentiation formation.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP Antibodies)-positive astrocytes for normal neurodevelopment.
we show by RNA silencing that CPE and SgIII (show SCG3 Antibodies) play a synergistic role in the trafficking of POMC (show POMC Antibodies) to granules of the regulated secretory pathway in AtT20 cells
An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.
This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 (show FGF2 Antibodies) and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior
The neuroprotective effect of CPE-DeltaN against neuronal glutamate (show GRIN1 Antibodies) neurotoxicity was mediated by secreted FGF2 (show FGF2 Antibodies).
Carboxypeptidase E is an important modulator of RANKL (show TNFSF11 Antibodies)-induced osteoclast differentiation.
Report the effects of ovalbumin (show OVA Antibodies) sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.
This study has identified CPE as a new neurotrophic factor (show NTF3 Antibodies) that can protect neurons against degeneration.
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
, carboxypeptidase E preproprotein
, carboxypeptidase E-like
, carboxypeptidase H
, cobalt-stimulated chromaffin granule carboxypeptidase
, enkephalin convertase
, insulin granule-associated carboxypeptidase
, prohormone-processing carboxypeptidase