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Human Polyclonal EXOC7 Primary Antibody for IHC (p), IHC - ABIN409080
Xu, Shen, Li, Pacheco-Rodriguez, Moss, Vaughan: Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. in Proceedings of the National Academy of Sciences of the United States of America 2005
the results identify Exo70 as a novel transcriptional target of HNF4alpha (show HNF4A Antibodies) to promote cell cycle progression in hepatoma, thus provide a basis for the development of therapeutic strategies for hepatocellular carcinoma.
the expression of CTTN (show CTTN Antibodies), Exo70 and MMP-9 (show MMP9 Antibodies) in HCC (show FAM126A Antibodies) cells was detected and their relations with the ability of migration and invasion of hepatoma carcinoma cells were evaluated
GIV (show CCDC88A Antibodies) directly and constitutively binds the exocyst complex subunit Exo-70 and also associates with GLUT4 (show SLC2A4 Antibodies)-storage vesicles (GSVs) exclusively upon insulin (show INS Antibodies) stimulation.
We show that Exo70, a component of the exocyst complex, undergoes isoform switching mediated by ESRP1 (show ESRP1 Antibodies), a pre-mRNA splicing factor (show SNRPB Antibodies) that regulates epithelial mesenchymal transition.
Exo70 thus represents a membrane-bending protein that may couple actin dynamics and plasma membrane remodeling for morphogenesis.
Exo70 is involved in caveolin-1 (show CAV1 Antibodies) recycling to the plasma membrane during re-adhesion of the cells to the substratum.
Exocyst component Exo70 is a direct substrate of the extracellular signal-regulated kinases 1/2, their phosphorylation enhances the binding of Exo70 to other exocyst components and promotes the assembly of the exocyst complex.
PIPKIgamma and phosphatidyl inositol phosphate pools at nascent E-cadherin (show CDH1 Antibodies) contacts cue Exo70 targeting and orient the tethering of exocyst-associated E-cadherin (show CDH1 Antibodies)
BIG2 (show ARFGEF2 Antibodies) and Exo70 interact in trans-Golgi network and centrosomes, as well as in exocyst structures or complexes that move along microtubules to the plasma membrane.
The exocyst complex is required for targeting of Glut4 (show SLC2A4 Antibodies) to the plasma membrane by insulin (show INS Antibodies)
Exo70 mediates AMPA (show GRIA3 Antibodies) receptor insertion at the postsynaptic membrane, but it does not participate in receptor targeting.
Given the low level of sequence conservation within Exo70, this structure provides new insights into our understanding of many species-specific functions of the exocyst
Results show that Snapin (show SNAPIN Antibodies) interacts with the exocyst Exo70 and plays a modulatory role in GLUT4 (show SLC2A4 Antibodies) vesicle trafficking.
fusion of GLUT4 (show SLC2A4 Antibodies) vesicles is the rate-limiting step regulated by insulin (show INS Antibodies) downstream of Exo70-mediated tethering
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4.
exocyst complex component Exo70
, exocyst component protein 70 kDa homolog
, exocyst complex component 7
, Exocyst complex component 7