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Results showed activin (show Actbeta Antibodies)-C and follistatin (show FST Antibodies) are differentially expressed during prostate development and suggested that the antagonistic property of follistatin (show FST Antibodies) is secondary to the action of activin (show Actbeta Antibodies)-C. Study provides evidence to support a role of activin (show Actbeta Antibodies)-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.
Data reinforces the importance of activin (show Actbeta Antibodies)-betaC in reproductive biology and suggests that activin (show Actbeta Antibodies)-betaC is a tumor modulator with gonadal specificity.
Data support the conclusion that activin (show Actbeta Antibodies) inhibits adrenal tumor growth promoted by luteinizing hormone by inducing adrenal x-zone regression.
results indicate that the beta(C) and beta(E) subunits of activin (show Actbeta Antibodies) form homo- and heterodimers, and that the functions of the two subunits are quite different
Study shows an up-regulation of activin (show Actbeta Antibodies)-C in aggressive prostate cancer only, suggesting that activin (show Actbeta Antibodies)-C may play a role in the advanced stages of the disease.
Activin A (show INHBA Antibodies), B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin (show Actbeta Antibodies) AC is not biologically active and does not act as a competitive antagonist.
Serum inhibin levels correlate with clinical characteristics and mortality in epithelial ovarian cancer patients.
The inhibin-betaC subunit is down-regulated, while inhibin-betaE is up-regulated by interferon-beta1a in Ishikawa carcinoma cell line.
Single Nucleotide Polymorphisms in INHBC gene is associated with brain metastasis in non-small-cell lung cancer
Activin-beta (show Actbeta Antibodies)(C) is a regulator of activin-A (show INHBA Antibodies). Activin-beta (show Actbeta Antibodies)(C) is able to abolish cachexia and modulate reproductive tumour development in inhibin alpha-subunit (show INHA Antibodies) knockout mice (alpha-KO) mice.
inhibin-betaC in normal and pathological placental tissue was demonstrated, although no differences in staining intensity could be observed. Functional role of novel inhibin-betaC subunit in normal and pathological human placenta is still quite unclear.
Data show that inhibin A levels were significantly lower in the PCOS group compared to the control group, and inhibin B levels were comparable in the two groups.
the novel inhibin/activin (show Actbeta Antibodies)-betaC subunit is expressed in human endometrioid adenocarcinomas and in the human endometrial carcinoma cell line HEC (show NDC80 Antibodies)-1a
Expression of the inhibin betaC and betaE subunits was demonstrated at the protein level and at the transcriptional level in normal human endometrial tissue and in the Ishikawa human endometrial carcinoma cell line.
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.
inhibin, beta C
, Activin beta-C chain
, activin beta-C chain
, activin/inhibin beta C
, inhibin beta C chain