TNF Receptor-Associated Factor 6 (TRAF6) (C-Term) Peptide
TRAF6
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2182428
Quick Overview for TNF Receptor-Associated Factor 6 (TRAF6) (C-Term) Peptide (ABIN2182428)
Target
TRAF6
(TNF Receptor-Associated Factor 6 (TRAF6))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TRAF6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
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Background
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TRAF6 is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. It may be essential for the formation of functional osteoclasts. It seems to also play a role in dendritic cells (DCs) maturation and/or activation. It represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. It regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.
Alias Symbols: MGC:3310, RNF85
Protein Size: 522 -
Molecular Weight
- 57 kDa
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Gene ID
- 7189
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NCBI Accession
- NM_004620, NP_004611
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UniProt
- Q9Y4K3
Target
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