Adenomatous Polyposis Coli (APC) (Middle Region) Peptide
APC
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512735
Quick Overview for Adenomatous Polyposis Coli (APC) (Middle Region) Peptide (ABIN5512735)
Target
APC
(Adenomatous Polyposis Coli (APC))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- SETFDNIDNL SPKASHRSKQ RHKQSLYGDY VFDTNRHDDN RSDNFNTGNM
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-APC Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APC (Adenomatous Polyposis Coli (APC))
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Background
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This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Alias Symbols: GS, DP2, DP3, BTPS2, DP2.5, PPP1R46
Protein Size: 1304 -
Gene ID
- 324
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NCBI Accession
- NM_000038, NP_000029
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UniProt
- E9PFT7
Target
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