Forkhead Box O4 (FOXO4) (C-Term) Peptide
FOXO4
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all FOXO4 products
- FOXO4 (Forkhead Box O4 (FOXO4))
- Protein Region
- C-Term
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PPVMAGAPIP KVLGTPVLAS PTEDSSHDRM PQDLDLDMYM ENLECDMDNI
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Foxo4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FOXO4 (Forkhead Box O4 (FOXO4))
- Background
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Foxo4 is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. It down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. It represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin.
Alias Symbols: Afxh, MGC117660, Mllt7, afx
Protein Size: 505 - Molecular Weight
- 54 kDa
- Gene ID
- 54601
- NCBI Accession
- NM_001005872, NP_001005872
- UniProt
- Q99MK2
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