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We identified calmodulin-like protein 3 (CALML3) as a key sensor of this SNP and a coregulator of ERalpha (show ESR1 Proteins), which contributes to differential gene transcription regulation in an estrogen and SERM-dependent fashion. Furthermore, using CRISPR/Cas9-engineered ZR75-1 breast cancer cells with different ZNF423 SNP genotypes, striking differences in cellular responses to SERMs and PARP inhibitors, alone or in combination
Loss of CALML3 predicts shorter overall and relapse-free survival in postoperative hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients, thus providing a prognostic biomarker and therapy target in HCC (show FAM126A Proteins).
Increased CALML3 expression in suprabasal layers is characteristic for differentiating keratinocytes in normal epidermis, and nuclear expression of CALML3 inversely correlates with expression of the proliferation marker Ki-67 (show MKI67 Proteins).
CLP may be required during terminal differentiation to increase myosin-10 function as cells migrate toward the upper layers and establish new adhesive contacts.
increased CLP expression and CLP-mediated Myo10 function are important for skin differentiation and wound reepithelialization
AtCML3 mediates dimerization of peroxisomal processing protease AtDEG15 and contributes to normal peroxisome metabolism. [AtCML3]
CML3 and CML30 are localized in peroxisomes and mitochondria, respectively. CML3 is targeted via an unusual C-terminal PTS1-like tripeptide while CML30 utilizes an N-terminal, non-cleavable transit peptide. [CML3]
May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates.
calmodulin-like protein 3
, caM-like protein
, calmodulin-related protein NB-1
, calmodulin 3 (phosphorylase kinase, delta)
, calmodulin, striated muscle