CALML3 Protein (His tag)
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- Target See all CALML3 Proteins
- CALML3 (Calmodulin Like Protein 3 (CALML3))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CALML3 protein is labelled with His tag.
- Purpose
- Recombinant Human CALML3 Protein (His Tag)
- Sequence
- Met 1-Lys 149
- Characteristics
- A DNA sequence encoding the human CALML3 (P27482) (Met 1-Lys 149) was expressed, with a polyhistide tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CALML3 Protein
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Calmodulin Like Protein 3 (CALML3) (AA 1-149) protein (GST tag)
CALML3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Calmodulin Like Protein 3 (CALML3) (AA 1-149) protein (Strep Tag)Crystallography grade CALML3 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Calmodulin Like Protein 3 (CALML3) protein (Myc-DYKDDDDK Tag)CALML3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CALML3 (Calmodulin Like Protein 3 (CALML3))
- Alternative Name
- CALML3 (CALML3 Products)
- Synonyms
- CLP Protein, 2310068O22Rik Protein, AI326174 Protein, CALM3 Protein, CCM1 Protein, calmodulin like 3 Protein, calmodulin-like 3 Protein, CALML3 Protein, Calml3 Protein
- Background
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Background: Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a tumor-sensitive protein specifically expressed in normal epithelial cells but downregulated in tumorigenesis. Downregulation of the protein is an early event in breast cancer development. One of the most pressing questions raised by the discovery of CLP/CALML3 is that of its potential targets. Although it is 85 % identical to human calmodulin, the distinct properties of CLP suggest that it has specific targets or targets that only partially overlap with those of calmodulin. Research has identified the unconventional myosin-10 (Myo10) as a specific target of CALML3. The discovery of Myo10 as a specific target of CALML3 is highly significant and suggests multiple lines of further research such as investigations of the Ca2+ regulation of Myo10 and the role of the loss of CLP in epithelial differentiation, adhesion, and cancer. Cells expressing CALML3 displayed a striking increase in the number and length of myosin-10-positive filopodia and showed increased mobility in a wound healing assay.
Synonym: CLP
- Molecular Weight
- 18.7kDa
- UniProt
- P27482
- Pathways
- Phototransduction
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