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anti-Human ATG13 Antibodies:
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Human Polyclonal ATG13 Primary Antibody for DB - ABIN1881081
Chan, Longatti, McKnight, Tooze: Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. in Molecular and cellular biology 2008
Show all 5 Pubmed References
Human Polyclonal ATG13 Primary Antibody for WB - ABIN1881080
Koh, Lin, Jedd, Wong: Sirius PSB: a generic system for analysis of biological sequences. in Journal of bioinformatics and computational biology 2009
Show all 5 Pubmed References
Human Polyclonal ATG13 Primary Antibody for ELISA, FACS - ABIN4282073
Joo, Dorsey, Joshi, Hennessy-Walters, Rose, McCastlain, Zhang, Iyengar, Jung, Suen, Steeves, Yang, Prater, Kim, Thompson, Youle, Ney, Cleveland, Kundu: Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. in Molecular cell 2011
these results demonstrate the effective anti-autophagic of NRAGE (show MAGED1 Antibodies) in non-small-cell lung cancer cells through AMPK (show PRKAA1 Antibodies)/Ulk1 (show ULK1 Antibodies)/Atg13 autophagy signaling pathways. Therefore, NRAGE (show MAGED1 Antibodies) could be used as a potential therapeutic target for lung cancer.
These results show that the SiMoA technology can detect quantitatively low levels of endogenous biomarkers with the ability to detect the loss of pSer(318)-Atg13 upon ULK1 (show ULK1 Antibodies) inhibition.
Structure of the human Atg13-Atg101 (show C12orf44 Antibodies) HORMA heterodimer in the ULK1 (show ULK1 Antibodies) complex that controls autophagy has been described.
Specific affinity of the LC3 (show MAP1LC3A Antibodies) isoforms to the Atg13 LC3 (show MAP1LC3A Antibodies)-interacting region is required for proper autophagosome formation.
In response to DNA damage, ULK1 (show ULK1 Antibodies) and ULK2 (show ULK2 Antibodies) are upregulated by p53 (show TP53 Antibodies). The upregulation of ULK1 (show ULK1 Antibodies) (ULK2 (show ULK2 Antibodies))/ATG13 complex by p53 (show TP53 Antibodies) is necessary for the sustained autophagy activity induced by DNA damage.
The gene product is the functional homologue of yeast Atg13, and required for autophagy in mammalian cells.
mTORC1 suppresses autophagy through direct regulation of the approximately 3-MDa ULK1 (show ULK1 Antibodies)-Atg13-FIP200 (show RB1CC1 Antibodies) complex.
The ULK-Atg13-FIP200 (show RB1CC1 Antibodies) complexes are direct targets of mTOR (show FRAP1 Antibodies) and important regulators of autophagy in response to mTOR (show FRAP1 Antibodies) signaling.
ATG13 and ULK1 (show ULK1 Antibodies) are phosphorylated by the mTOR (show FRAP1 Antibodies) pathway in a nutrient starvation-regulated manner, indicating that the ULK1 (show ULK1 Antibodies).ATG13.FIP200 (show RB1CC1 Antibodies) complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis.
The identification of the novel protein, Atg101 (show C12orf44 Antibodies), and the validation of Atg13 and Atg101 (show C12orf44 Antibodies) as ULK1 (show ULK1 Antibodies)-interacting proteins, suggests an Atg1 (show ULK1 Antibodies) complex is involved in the induction of macroautophagy in mammalian cells.
ATG7 (show ATG7 Antibodies), but not ATG13 or ULK1 (show ULK1 Antibodies) has a role in functional autophagy in glioblastoma development
ATG13 phosphorylation plays a crucial role in autophagy regulation.
autophagy can be executed by mechanisms that are dependent or independent of the ULK1 (show ULK1 Antibodies)/2-ATG13 interaction.
Atg13-deficient embryos show growth retardation and myocardial growth defects.
Autophagy factor required for autophagosome formation (By similarity). Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex (By similarity).
ATG13 autophagy related 13 homolog
, autophagy-related protein 13
, harbinger transposase derived 1
, hypothetical protein