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Human Polyclonal BIM Primary Antibody for ELISA, IHC - ABIN4284640
Zhang, Gillespie, Borrow, Hersey: The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. in Molecular cancer therapeutics 2004
Show all 7 Pubmed References
Human Polyclonal BIM Primary Antibody for WB - ABIN222941
Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007
Show all 3 Pubmed References
Human BIM Primary Antibody for IHC - ABIN965668
Fukazawa, Noguchi, Masumi, Murakami, Uehara: BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. in Molecular cancer therapeutics 2004
Show all 2 Pubmed References
Human Polyclonal BIM Primary Antibody for IHC - ABIN965669
Luciano, Jacquel, Colosetti, Herrant, Cagnol, Pages, Auberger: Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. in Oncogene 2003
Show all 2 Pubmed References
Human Polyclonal BIM Primary Antibody for ELISA, WB - ABIN250248
Jiang, Lucas, Avery-Kiejda, Wade, deBock, Thorne, Allen, Hersey, Zhang: Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. in Cancer research 2008
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Human Polyclonal BIM Primary Antibody for IF (p), IHC (p) - ABIN682873
Gogada, Yadav, Liu, Tang, Zhang, Schneider, Seshadri, Sun, Aldaz, Tang, Chandra: Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. in The Journal of biological chemistry 2013
Human Polyclonal BIM Primary Antibody for IHC, IHC (p) - ABIN4284636
Cash, Gruber, Hartman, Henske, Simon: Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription. in Oncogene 2011
Human Polyclonal BIM Primary Antibody for IHC (p), WB - ABIN388101
Chen, Zhou: Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Cloning and functional analysis of the bim gene.
Hypermethylation of the proapoptotic genes BCL2 L11 and TNFRSF25 (show TNFRSF25 Antibodies) is observed in pleomorphic adenoma of the salivary glands. However, this phenomenon did not impact mRNA transcription.
Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator (show PTBP2 Antibodies) SRP55 (show SRSF6 Antibodies); SRP55 (show SRSF6 Antibodies)-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM, BAX (show BAX Antibodies)), JNK (show MAPK8 Antibodies) signaling, and endoplasmic reticulum stress. (SRP55 (show SRSF6 Antibodies) = pre-mRNA-splicing factor SRP55 (show SRSF6 Antibodies); BAX (show BAX Antibodies) = apoptosis regulator BAX (show BAX Antibodies))
Bim expression was significantly different in the four molecular subtypes of breast cancer.
BIM deletion is a significant predictor of shorter PFS and OS on EGFR (show EGFR Antibodies)-TKIs. Further studies to determine its effect on response to other BIM-dependent therapeutic agents are needed, so that alternative treatment strategies may be devised.
These findings indicate the importance of developing HDAC3 (show HDAC3 Antibodies)-selective inhibitors, and their combined use with osimertinib, for treating EGFR (show EGFR Antibodies)-mutated lung cancers carrying the BIM deletion polymorphism
Low BIM expression is associated with renal cell carcinoma (show MOK Antibodies).
The decreased miR (show MLXIP Antibodies)-101-3p caused elevated Bim expression by targeting its 3'-untranslated region (3'-UTR (show UTS2R Antibodies)).
The mitochondrial apoptotic pathway, activated by BH3-only (show BBC3 Antibodies) proteins, BIM and PUMA (show BBC3 Antibodies), is essential for endoplasmic reticulum stress-induced cell death; DR5 (show TNFRSF10B Antibodies) as well as caspase-8 (show CASP8 Antibodies) are not required for this process.
sequestration of Bim by Mcl-1 (show MCL1 Antibodies) is a mechanism of intrinsic ABT-199 resistance and supports the clinical development of ABT-199 in combination with cytarabine or daunorubicin for the treatment of AML (show RUNX1 Antibodies).
Knock down of VDR (show CYP27B1 Antibodies) and BIM reduces the enhancement of cell death treated with Cytarabine (AraC) followed by the addition of Doxercalciferol together with Carnosic acid (CA).
the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival.
Proapoptotic proteins BIM and PUMA (show BBC3 Antibodies) are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL (show BCL2L1 Antibodies).
Increased expression of miR-214 suppresses PTEN expression and represses Bim1 expression.
Study provides evidence that Bim transcription which is dependent of FOXO3A (show FOXO3 Antibodies) protects mice from a high fat diet via inhibition of activation of the NLRP3 (show NLRP3 Antibodies) inflammasome by facilitating autophagy flux in Kupffer cells.
We propose that the GC-induced mitochondrial accumulation of Bax (show BAX Antibodies) and the interaction between the GR and Bim, Bcl-xL (show BCL2L1 Antibodies) and Bak (show BAK1 Antibodies) could play a role in the regulation of thymocyte apoptosis.
Bcl2l11 as the direct target of miR (show MLXIP Antibodies)-9 and manipulation of miR (show MLXIP Antibodies)-9 induces the corresponding changing of Bcl2l11 protein level.
these data suggest that the Bim may be a novel therapeutic target in the treatment of systemic lupus erythematosus.
Data show that the induction of BIM in the MYC (show MYC Antibodies)- and RAS-driven leukemia is mediated by the downregulation of miR-17-92, and suggest that induction of BIM-mediated apoptosis may be a therapeutic approach for acute lymphoblastic leukemia (ALL).
Conversion of Bim-BH3 from Activator to Inhibitor of Bak (show BAK1 Antibodies) through Structure-Based Design.
Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 Antibodies)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 Antibodies)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Antibodies).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein