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Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
Results show that CCND1 expression is regulated by LET7A which directly targets its 3'UTR in A549 lung cancer cells.
Authors found that the phenotypic alterations by miR (show MLXIP Proteins)-365 were partially due to downregulation of CCND1 and BCL2 (show BCL2 Proteins) oncogenes.
USP22 (show USP22 Proteins) and CCND1 levels correlate in patient lung and colorectal cancer samples and our preclinical studies indicate that targeting USP22 (show USP22 Proteins) in combination with CDK (show CDK4 Proteins) inhibitors may offer an approach for treating cancer patients whose tumors exhibit elevated CCND1.
miR449a5p may control squamous cell carcinoma proliferation through the negative regulation of cyclin D1 expression.
Findings demonstrated that Cyclin D1 is overexpressed in hepatocellular carcinoma cells (HCC (show FAM126A Proteins)) and that its silencing can suppress cell proliferation and promote cell apoptosis of HCC (show FAM126A Proteins).
uc.338 could promote proliferation and cell cycle G1/S transition, and might target p21 (show CDKN1A Proteins) downregulation and cyclin D1 upregulation.
overexpressed PKM2 (show PKM Proteins) led to increased CCND1 and decreased CDKN1A expression, whereas underexpressed PKM2 (show PKM Proteins) led to decreased CCND1 and increased CDKN1A expression in ovarian cancer cells.
High CCND1 Expression is associated with breast cancer.
CCND1 G870A polymorphism may increase the risk of lung cancer in smokers from North India, and it may be associated with the overall survival of small-cell lung cancer patients
these results define a tumor-supportive role for CDCA3 (show CDCA3 Proteins).
results suggest that DGKdelta controls the down-regulation of cyclin D1 expression by attenuating the PKC signaling pathway for C2C12 myogenic differentiation
the focal adhesion component paxillin (show PXN Proteins) is a cytoplasmic substrate of Ccnd1.Cdk4 (show CDK4 Proteins).
Since miR (show MLXIP Proteins)-290 cluster miRNAs are the most dominant stem-cell-specific miRNAs, our results revealed an important cause for the absence of Cyclin D1 in mouse embryonic stem cells
beta-catenin (show CTNNB1 Proteins) and p65 (show NFkBP65 Proteins) are activated in separate cellular compartments during liver regeneration, with p65 (show NFkBP65 Proteins) activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin (show CTNNB1 Proteins), cyclin D1 expression, and subsequent proliferation
Ablation of periostin (show POSTN Proteins) suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin (show POSTN Proteins) is essential for myocardial regeneration.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF (show CSF1R Proteins)/c-Fms (show CSF1R Proteins)-mediated downstream signaling pathways like activation of ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (show CTNNB1 Proteins)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (show PAX5 Proteins) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Methylparabens exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a (show SMC1A Proteins) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (show MEIS1 Proteins) regulating cyclin D1 and c-myc (show MYC Proteins) transcription in the embryonic eye.
Results suggest that the TCF (show HNF4A Proteins)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (show CDK2 Proteins) and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (show MAPK3 Proteins) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1