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Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
Further study revealed AP000439.3 can regulate expression of CCND1 through enhancing estrogen receptor (show ESR1 Proteins) induction of CCND1. This finding revealed lncRNAs may serve as important effectors of ER in regulation of gene expression and cell phenotype in breast cancer
miR (show MLXIP Proteins)-720 acted as a tumour suppressor in pancreatic cancer by directly targeting CCND1.
Results identified NKX2-1 (show NKX2-1 Proteins)-binding motifs in the cyclin D1 promoter and indicate that NKX2-1 (show NKX2-1 Proteins) directly and positively regulates transcription of cyclin D1 in lung adenocarcinoma.
Results suggest that dysregulation and activation of the cell cycle proteins CDK4 (show CDK4 Proteins)/CDK6 (show CDK6 Proteins)-CCND1-phospho-RB1 (show RB1 Proteins) axis is associated with higher proliferative index in neuroendocrine tumors (NETs).
Results indicated that miR (show MLXIP Proteins)-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting cyclin D1 (CCND1) and ETS (show ETS1 Proteins) proto-oncogene (show RAB1A Proteins) 1 (ETS1 (show ETS1 Proteins)) expression.
Greater frequency of cyclin D1 expression was revealed in normal endometrial tissues in comparison with carcinomas. The distribution pattern of cyclin D1 immunoexpression suggests poor prognoses in endometrial carcinoma patients.
High Expression of CCND1 is associated with liver cancer.
Impact of 9p deletion and p16, Cyclin D1, and Myc (show MYC Proteins) hyperexpression on the outcome of anaplastic oligodendrogliomas.
These findings indicate that miRNA494 and its target cyclin D1 may be a crucial axis for Nerve growth factor in regulating the proliferation of human corneal epithelial cell.
INSR (show INSR Proteins) rs1051690 SNP is associated with increased risk of gastric cancer, while polymorphisms in IL12B (show IL12B Proteins), CCND1 and IL10 (show IL10 Proteins) genes are not linked with the presence of gastric cancer
Since miR (show MLXIP Proteins)-290 cluster miRNAs are the most dominant stem-cell-specific miRNAs, our results revealed an important cause for the absence of Cyclin D1 in mouse embryonic stem cells
beta-catenin (show CTNNB1 Proteins) and p65 (show NFkBP65 Proteins) are activated in separate cellular compartments during liver regeneration, with p65 (show NFkBP65 Proteins) activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin (show CTNNB1 Proteins), cyclin D1 expression, and subsequent proliferation
Ablation of periostin (show POSTN Proteins) suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin (show POSTN Proteins) is essential for myocardial regeneration.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF (show CSF1R Proteins)/c-Fms (show CSF1R Proteins)-mediated downstream signaling pathways like activation of ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (show CTNNB1 Proteins)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (show PAX5 Proteins) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), Klf4 (show KLF4 Proteins), and c-Myc (show MYC Proteins) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (show PLCG1 Proteins) controls osteoclast numbers via a CSF-1 (show CSF1 Proteins)-dependent DAG/beta-catenin (show CTNNB1 Proteins)/cyclinD1 pathway.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a (show SMC1A Proteins) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (show MEIS1 Proteins) regulating cyclin D1 and c-myc (show MYC Proteins) transcription in the embryonic eye.
Results suggest that the TCF (show HNF4A Proteins)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (show CDK2 Proteins) and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (show MAPK3 Proteins) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1