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anti-Human Hexokinase 2 Antibodies:
anti-Mouse (Murine) Hexokinase 2 Antibodies:
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Human Polyclonal Hexokinase 2 Primary Antibody for WB - ABIN1882090
Kuwabara, Ishikawa, Kobayashi, Kobayashi, Sugiyama: Renal clearance of a recombinant granulocyte colony-stimulating factor, nartograstim, in rats. in Pharmaceutical research 1996
Show all 5 Pubmed References
Human Monoclonal Hexokinase 2 Primary Antibody for FACS, IHC - ABIN969196
Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. in Cell 2006
Show all 3 Pubmed References
Human Monoclonal Hexokinase 2 Primary Antibody for ELISA, FACS - ABIN4317173
Fong, Jing, Smalley, Taccioli, Fahrmann, Barupal, Alder, Farber, Fiehn, Croce: Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia. in Oncotarget 1970
Human Polyclonal Hexokinase 2 Primary Antibody for IHC (p), WB - ABIN392755
Laakso, Malkki, Deeb: Amino acid substitutions in hexokinase II among patients with NIDDM. in Diabetes 1995
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Human Monoclonal Hexokinase 2 Primary Antibody for ELISA, WB - ABIN532978
Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997
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Human Polyclonal Hexokinase 2 Primary Antibody for IHC (p), ELISA - ABIN544931
Lehto, Huang, Davis, Le Beau, Laurila, Eriksson, Bell, Groop: Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity. in Diabetologia 1996
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Mouse (Murine) Polyclonal Hexokinase 2 Primary Antibody for IHC, WB - ABIN3021256
Guo, Yao, Zhan, Hu, Yue, Cheng, Liu, Ye, Qing, Zhang, Liu: N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. in Toxicology and applied pharmacology 2014
Human Polyclonal Hexokinase 2 Primary Antibody for WB - ABIN516456
Lee, Lee, Park, Park, Namgung: Relationship Between Dual-Time Point FDG PET and Immunohistochemical Parameters in Preoperative Colorectal Cancer: Preliminary Study. in Nuclear medicine and molecular imaging 2014
Human Monoclonal Hexokinase 2 Primary Antibody for ELISA, WB - ABIN516457
Richter, Richter, Mehta, Gribble, Sutherland-Smith, Stowell, Print, Ronimus, Wilson: Expression and role in glycolysis of human ADP-dependent glucokinase. in Molecular and cellular biochemistry 2012
our findings demonstrate for the first time that hypoxia-down-regulated miR-125a regulated HCC glycolysis and carcinogenesis by targeting hexokinase HK2, a key glycolytic enzyme for the Warburg effect, and add a new dimension to hypoxia-mediated regulation of cancer metabolism.
downregulation of HK2 gene may be caused by its negative regulation through microRNAs miR-9-5p, -98-5p, and -199-5p.
Mutation in c-Src phosphorylation site of either HK1 or HK2 remarkably abrogates the stimulating effects of c-Src on glycolysis, cell proliferation, migration, invasion, tumorigenesis and metastasis
this study reports the structure of HK2 in complex with glucose and glucose-6-phosphate (G6P).
Altogether, these findings provide strong support for the direct contribution of HK2 in B-cell lymphoma development and suggest that HK2 is a key metabolic driver of the diffuse large B-cell lymphoma phenotype.
Taken together, these findings suggested that UCA1 may have an important role in regulating radioresistance through the HK2/glycolytic pathway, providing novel potential targets to improve cervical cancer RT.
Data suggest that HK2 plays role in cisplatin resistance in ovarian cancer by regulating drug-induced, MAP kinase signaling-mediated autophagy.
miR-125b-5p-HK2 pathway as a novel mechanism in regulating the glycolysis and progression of Laryngeal squamous cell carcinoma.
These findings provide clues regarding the role of miR-216a-5p as a tumor suppressor in uveal melanoma through the inhibition of HK2.
Overexpression of miR-125b inhibits cellular glucose metabolism through direct targeting of hexokinase 2.
Data indicate that hexokinase-2 (HK2) was the direct target of miR-125b.
Tesults suggest that mTOR-STAT3-HK2 pathway is involved in the glycolysis of HCC cells and STAT3 may regulate HCC glycolysis through HK2 pathway.
our results demonstrate that deregulation of HK2 expression has an important function in the progression of TSCC and may serve as a biomarker of its metastatic potential in TSCC patients. HK2 enhances the metastatic potential of TSCC by stimulating the SOD2-H2O2 pathway.
present studies highlight miR-143 as a tumor suppressor in oral squamous cell carcinoma (OSCC) by the suppression of cell migration, glucose metabolism and proliferation through directly targeting HK2, rendering miR-143 a therapeutic strategy for the treatment of clinical OSCC patients.
FOXM1 bound directly to the GLUT1 and HK2 promoter regions and regulated the promoter activities and the expression of the genes at the transcriptional level. This reveals a novel mechanism by which glucose metabolism is regulated by FOXM1.
our findings supported a mechanism whereby targeting HK2 inhibition contributed to suppress HPV16 E7-induced tumor glycolysis metabolism phenotype, inhibiting tumor growth, and induced apoptosis, blocking the cancer cell energy sources and ultimately enhanced the sensitivity of HPV(+) cervical cancer cells to irradiation therapy
Data suggest Hexokinase 2 (HK2) as a potentially effective therapeutic target in Glioblastoma (GBM).
High HKII expresiion is associated with nasopharyngeal carcinoma.
Results show that the hexokinase 2 (HK2) promoter CpG island (HK2-CGI) surrounding regions N-shore was hypomethylated, thereby enhancing HK2 expression, the HK2-CGI was itself hypermethylated in some hepatocellular carcinomas (HCCs).
findings confirmed the tumorigenic activity of HK2 in glioma, and the involvement of the miR218/Bmi1 pathway in the regulation of its expression
Kaempferol inhibited mitochondrial fission and maintained mitochondrial HK-II through activation of Akt, and thereby protected neurons from succinate-mediated ischemi injury.
In high-fat diet fed mice, oral administration of mangiferin induced Akt phosphorylation, increased HK-II binding to mitochondria and resultantly protected vessel endothelial function, demonstrating its protective effect on endothelial integrity in vivo.
Studied melatonin's role in microvascular ischemia/reperfusion injury; found melatonin plays a protective role in mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis signal pathway suppression.
microcirculatory ischemia/reperfusion injury can be attributed to Mff-dependent mitochondrial fission via voltage-dependent anion channel 1/hexokinase 2-mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt-c release.
CD4 T cell mediated immuno-inflammatory responses to a virus infection were similar between WT and HK2 KO animals. The observations that the expression of HK2 appears non-essential for CD4 T cell responses against virus infections is of interest since it suggests that targeting HK2 for cancer therapy may not have untoward effects on CD4 T cell mediated immune response against virus infections.
BAG3 directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.
changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 mutations. HK2 is required for Pten-/p53-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS accumulation via increased pentose phosphate pathway flux.
phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt.
Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.
HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy.
We identified miR-143 as an essential regulator of cancer glycolysis via targeting HK2.
PPARgamma contributes to PKM2 and HK2 expression in fatty liver
In a cardiac low-flow ischaemia-reperfusion model, resulting in only mild injury, standard chow or reduced HKII does not significantly affect ischaemia-reperfusion damage.
Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, hexokinase 2
, likely hexokinase II