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anti-Human Hexokinase 2 Antibodies:
anti-Mouse (Murine) Hexokinase 2 Antibodies:
anti-Rat (Rattus) Hexokinase 2 Antibodies:
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Human Polyclonal Hexokinase 2 Primary Antibody for WB - ABIN1882090
Kuwabara, Ishikawa, Kobayashi, Kobayashi, Sugiyama: Renal clearance of a recombinant granulocyte colony-stimulating factor, nartograstim, in rats. in Pharmaceutical research 1996
Show all 5 Pubmed References
Human Monoclonal Hexokinase 2 Primary Antibody for FACS, IHC - ABIN969196
Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. in Cell 2006
Show all 3 Pubmed References
Human Polyclonal Hexokinase 2 Primary Antibody for WB - ABIN516456
Lee, Lee, Park, Park, Namgung: Relationship Between Dual-Time Point FDG PET and Immunohistochemical Parameters in Preoperative Colorectal Cancer: Preliminary Study. in Nuclear medicine and molecular imaging 2014
Human Monoclonal Hexokinase 2 Primary Antibody for ELISA, WB - ABIN516457
Richter, Richter, Mehta, Gribble, Sutherland-Smith, Stowell, Print, Ronimus, Wilson: Expression and role in glycolysis of human ADP-dependent glucokinase. in Molecular and cellular biochemistry 2012
Human Monoclonal Hexokinase 2 Primary Antibody for ELISA, FACS - ABIN4317173
Fong, Jing, Smalley, Taccioli, Fahrmann, Barupal, Alder, Farber, Fiehn, Croce: Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia. in Oncotarget 1970
Human Polyclonal Hexokinase 2 Primary Antibody for IHC (p), WB - ABIN392755
Laakso, Malkki, Deeb: Amino acid substitutions in hexokinase II among patients with NIDDM. in Diabetes 1995
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Mouse (Murine) Polyclonal Hexokinase 2 Primary Antibody for IHC, WB - ABIN3021256
Guo, Yao, Zhan, Hu, Yue, Cheng, Liu, Ye, Qing, Zhang, Liu: N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. in Toxicology and applied pharmacology 2014
Tesults suggest that mTOR (show FRAP1 Antibodies)-STAT3 (show STAT3 Antibodies)-HK2 pathway is involved in the glycolysis of HCC (show FAM126A Antibodies) cells and STAT3 (show STAT3 Antibodies) may regulate HCC (show FAM126A Antibodies) glycolysis through HK2 pathway.
our results demonstrate that deregulation of HK2 expression has an important function in the progression of TSCC and may serve as a biomarker of its metastatic potential in TSCC patients. HK2 enhances the metastatic potential of TSCC by stimulating the SOD2 (show SOD2 Antibodies)-H2O2 pathway.
present studies highlight miR (show MLXIP Antibodies)-143 as a tumor suppressor in oral squamous cell carcinoma (OSCC) by the suppression of cell migration, glucose metabolism and proliferation through directly targeting HK2, rendering miR (show MLXIP Antibodies)-143 a therapeutic strategy for the treatment of clinical OSCC patients.
FOXM1 (show FOXM1 Antibodies) bound directly to the GLUT1 (show SLC2A1 Antibodies) and HK2 promoter regions and regulated the promoter activities and the expression of the genes at the transcriptional level. This reveals a novel mechanism by which glucose metabolism is regulated by FOXM1 (show FOXM1 Antibodies).
our findings supported a mechanism whereby targeting HK2 inhibition contributed to suppress HPV16 E7-induced tumor glycolysis metabolism phenotype, inhibiting tumor growth, and induced apoptosis, blocking the cancer cell energy sources and ultimately enhanced the sensitivity of HPV(+) cervical cancer cells to irradiation therapy
Data suggest Hexokinase 2 (HK2) as a potentially effective therapeutic target in Glioblastoma (GBM).
High HKII expresiion is associated with nasopharyngeal carcinoma.
Results show that the hexokinase 2 (HK2) promoter CpG island (HK2-CGI) surrounding regions N-shore was hypomethylated, thereby enhancing HK2 expression, the HK2-CGI was itself hypermethylated in some hepatocellular carcinomas (HCCs (show HCCS Antibodies)).
findings confirmed the tumorigenic activity of HK2 in glioma, and the involvement of the miR218/Bmi1 (show BMI1 Antibodies) pathway in the regulation of its expression
BAG3 (show BAG3 Antibodies) directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.
Studied melatonin's role in microvascular ischemia/reperfusion injury; found melatonin plays a protective role in mitochondrial fission-VDAC1 (show VDAC1 Antibodies)-HK2-mPTP (show PTPN2 Antibodies)-mitophagy axis signal pathway suppression.
microcirculatory ischemia/reperfusion injury can be attributed to Mff (show MFF Antibodies)-dependent mitochondrial fission via voltage-dependent anion channel 1 (show VDAC1 Antibodies)/hexokinase 2-mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt-c (show CYCS Antibodies) release.
CD4 (show CD4 Antibodies) T cell mediated immuno-inflammatory responses to a virus infection were similar between WT and HK2 KO animals. The observations that the expression of HK2 appears non-essential for CD4 (show CD4 Antibodies) T cell responses against virus infections is of interest since it suggests that targeting HK2 for cancer therapy may not have untoward effects on CD4 (show CD4 Antibodies) T cell mediated immune response against virus infections.
changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (show SIRT3 Antibodies) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 (show TP53 Antibodies) mutations. HK2 is required for Pten-/p53 (show TP53 Antibodies)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (show SLC2A1 Antibodies) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, hexokinase 2
, likely hexokinase II