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BCL2 (show BCL2 ELISA Kits) expression in mesennchymal lung cancer cells was induced by ERK1 (show MAPK3 ELISA Kits) activity through the upregulation of the MEK1 (show MAP2K1 ELISA Kits)/ERK1 (show MAPK3 ELISA Kits) scaffold protein (show HOMER1 ELISA Kits) MEK partner-1. Interfering with the MEK1 (show MAP2K1 ELISA Kits)/MP1/ERK1 (show MAPK3 ELISA Kits) axis using a MEK1 (show MAP2K1 ELISA Kits) inhibitor or MP1 depletion repressed BCL2 (show BCL2 ELISA Kits) expression and sensitized MLCCs to chemoradiotherapy.
The present study was aimed at investigating whether the miR (show MLXIP ELISA Kits)-29c binding site single nucleotide polymorphisms within the 3'-UTRs of LAMTOR3 gene affected the gastric cancer risk.
we demonstrate that the MAPK (show MAPK1 ELISA Kits) scaffold protein (show HOMER1 ELISA Kits) MEK partner 1 (MP1) is important for gastrin (show GAST ELISA Kits)-induced phosphorylation of ERK1 (show MAPK3 ELISA Kits) and ERK2 (show MAPK1 ELISA Kits) and that MP1 promotes gastrin (show GAST ELISA Kits)-induced proliferation of AGS (show JAG1 ELISA Kits)-GR cells
identified polymorphisms in LAMTOR2 (show LAMTOR2 ELISA Kits) and LAMTOR3 do not seem to play a relevant role in breast cancer
A complex encoded by the MAPKSP1, ROBLD3 (show LAMTOR2 ELISA Kits), and c11orf59 (show LAMTOR1 ELISA Kits) genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
We investigated the neuroprotective effect of glial-derived neurotrophic factor (GDNF) upon alcohol-exposed B92 cultures, as well as the role of the cytoskeleton and mitogen-activated protein kinase (show MAPK1 ELISA Kits) (MAPK (show MAPK1 ELISA Kits)) pathways in this effect.
This novel mechanism for localization of intracellular Leishmania amazonensis-mediated ERK1/2 phosphorylation required the endosomal scaffold protein MP1 and localized to Leishmania amazonensis parasitophorous vacuoles.
We show an essential function for late endosomes carrying the p14 (show PCOLCE ELISA Kits)-MP1 (LAMTOR2 (show LAMTOR2 ELISA Kits)/3) complex in focal adhesion dynamics.
Data indicate that LAMTOR3 protein is stabilized by associating with LAMTOR2 (show LAMTOR2 ELISA Kits).
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.
MP1 and the MP1*P14 (show PCOLCE ELISA Kits) complex have the potential to differentially modulate activating and inhibiting signals in the Raf (show RAF1 ELISA Kits)-MKK1 (show MAP2K1 ELISA Kits)/2-ERK1/2 (show MAPK1/3 ELISA Kits) pathway.
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
MAPK scaffold protein 1
, mitogen-activated protein kinase kinase 1 interacting protein 1
, MEK binding partner 1
, late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
, mitogen-activated protein kinase scaffold protein 1
, ragulator complex protein LAMTOR3
, MEK-binding partner 1
, mitogen activated protein, binding protein
, mitogen-activated protein kinase kinase 1-interacting protein 1
, MEK partner 1
, Mitogen-activated protein kinase kinase 1-interacting protein 1
, Mitogen-activated protein kinase scaffold protein 1
, putative mitogen-activated protein kinase kinase 1 interacting protein 1