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anti-Mouse (Murine) Microtubule Star Antibodies:
anti-Human Microtubule Star Antibodies:
anti-Rat (Rattus) Microtubule Star Antibodies:
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Mouse (Murine) Monoclonal Microtubule Star Primary Antibody for IP, WB - ABIN1042659
Hombauer, Weismann, Mudrak, Stanzel, Fellner, Lackner, Ogris: Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. in PLoS biology 2007
Show all 8 Pubmed References
Human Polyclonal Microtubule Star Primary Antibody for IHC, ELISA - ABIN1585085
Ren, Shen, Sun, Shu, Shen, Bu, Ai, Zhang, Tang, Tian, Li, Li, Ma: Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development. in Cancer letters 2016
PP2B-Abeta (show APP Antibodies) limits platelet response to vascular injury by suppressing outside-in alphaII b beta3 integrin (show ITGB3 Antibodies) signaling
TRPV1 (show TRPV1 Antibodies) activation in endothelial cells may elicit a Ca(2 (show CA2 Antibodies)+) -dependent effect on PP2B-PKC (show PKC Antibodies) signalling, which leads to dephosphorylation of eNOS (show NOS3 Antibodies)
PP2A (show PPP2R2B Antibodies) activation via rapid, non-nuclear ER signaling may be a novel target for therapeutic approaches to inhibit vascular smooth muscle proliferation, which plays a central role in atherosclerosis and restenosis.
This study provides evidence that CaBP4 (show CABP4 Antibodies) is dephosphorylated by PP2A (show PPP2R2B Antibodies) in the retina.
generated conditional null alleles of Ppp2ca (show PPP2CA Antibodies) and Ppp2cb (show PPP2CA Antibodies) by flanking with loxP sites exons 3 to 5 of Ppp2ca (show PPP2CA Antibodies) and exon 3 of Ppp2cb (show PPP2CA Antibodies). Ppp2ca (show PPP2CA Antibodies)(fl/fl (show FLT3LG Antibodies)) mice did not display any visible phenotype
calcineurin signaling plays a critical role in regulating skeletal muscle fiber type switching but not hypertrophy
Protein phosphatase 2Ac (alpha) can negatively regulate integrin alpha(IIb)beta(3) signaling by suppressing the ERK1/2 (show MAPK1/3 Antibodies) signaling pathway
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
PP2A (show PPP2R2B Antibodies)/C provides a dual inhibitory effect on Bcl2 (show BCL2 Antibodies)'s survival function by both dephosphorylating Bcl2 (show BCL2 Antibodies) and enhancing p53 (show TP53 Antibodies)-Bcl2 (show BCL2 Antibodies) binding.
Moreover, PP2Acalpha2-overexpressed cells demonstrated increased expression of IGBP1 (show IGBP1 Antibodies), activated mTORC1 signaling to reduce basal autophagy and increased anchorage-independent growth. Our study provides new insights into the complex mechanisms of PP2A (show PPP2R4 Antibodies) regulation.
protein phosphatase 2A (PP2A (show PPP2R4 Antibodies))-mediated Raf (show RAF1 Antibodies)-MEK (show MAP2K1 Antibodies)-ERK (show EPHB2 Antibodies) signaling was involved in glutaminolysis in endothelial cells.
Studies indicate that protein phosphatase methylesterase-1 (PME-1 (show PPME1 Antibodies)) negatively regulates protein phosphatase 2A (PP2A (show PPP2R4 Antibodies)) activity by highly complex mechanisms.
Binding of PP2A (show PPP2R4 Antibodies) and Akt (show AKT1 Antibodies) increased in response to cAMP or phosphatidic acid (PA), suggesting that their binding is directly responsible for the inactivation of Akt (show AKT1 Antibodies) during decidualization.
Knockdown of Alpha4 preferentially impacts the expression of PP4c (show PPP4C Antibodies) and PP6c (show PPP6C Antibodies) compared to expression levels of PP2Ac (show PPP2CA Antibodies).
these data support a role for the novel PP2Ac (show PPP2CA Antibodies)-CIN85 (show SH3KBP1 Antibodies) complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
PP2Ac (show PPP2CA Antibodies) upregulation has a poor prognostic impact on the overall survival of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) patients and contributes to the aggressiveness of HCC (show FAM126A Antibodies). PP2Ac (show PPP2CA Antibodies) may represent a potential therapeutic target for HCC (show FAM126A Antibodies).
Data show that downregulating proto-oncogene (show RAB1A Antibodies) protein Akt (p-Akt (show AKT1 Antibodies)) by inhibiting PP2A (show PPP2R4 Antibodies) inhibitor SET-mediated protein phosphatase 2A (PP2A (show PPP2R4 Antibodies)) inactivation determined the pro-apoptotic effects of EMQA and paclitaxel combination treatment.
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) deficient castration resistant prostate cancer (CRPC) progression.
that loss of glucocerebrosidase function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
, protein phosphatase 2a, catalytic subunit, beta isoform
, serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
, protein phosphatase 2A catalytic subunit, alpha isoform
, replication protein C
, serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform