Browse our anti-PDPK1 (PDPK1) Antibodies

Full name:: anti-3-phosphoinositide Dependent Protein Kinase-1 Antibodies (PDPK1)

On www.antibodies-online.com are 458 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antibodies from 32 different suppliers available. Additionally we are shipping PDPK1 Proteins (30) and PDPK1 Kits (25) and many more products for this protein. A total of 545 PDPK1 products are currently listed.

Synonyms:: 3'-phosphoinositide-dependent protein kinase 1, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, 1210, ATP5A, AtPDK1, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, si:zfos-979f1.3, T32M21.110, T32M21_110, zgc:77318

list all antibodies	Gene Name	GeneID	UniProt
	PDPK1	81745	O55173
	PDPK1	5170	O15530
	PDPK1	18607	Q9Z2A0
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Most Popular Reactivities for anti-PDPK1 (PDPK1) Antibodies

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anti-Rat (Rattus) PDPK1 Antibodies:

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anti-Mouse (Murine) PDPK1 Antibodies:

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Relevant Pathways for anti-PDPK1 Antibodies

VEGFR1 Specific Signals

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Top referenced anti-PDPK1 Antibodies

Human PDPK1 Primary Antibody for IHC - ABIN966815 : Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. in Molecular and cellular biology 2005 (PubMed)
Show all 4 Pubmed References
Human Polyclonal PDPK1 Primary Antibody for IHC - ABIN966816 : Chen, Nystrom, Dong, Li, Song, Liu, Quon: Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism. in Biochemistry 2001 (PubMed)
Show all 5 Pubmed References
Human Monoclonal PDPK1 Primary Antibody for ICC, FACS - ABIN969347 : Seong, Jung, Kim, Ha: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. in The Journal of biological chemistry 2007 (PubMed)
Show all 3 Pubmed References
Human Polyclonal PDPK1 Primary Antibody for WB - ABIN250778 : Ho, Coomber: Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. in Experimental cell research 2015 (PubMed)
Show all 3 Pubmed References
Human Polyclonal PDPK1 Primary Antibody for ICC, IF - ABIN250776 : Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. in The Biochemical journal 2014 (PubMed)
Show all 3 Pubmed References
Human Polyclonal PDPK1 Primary Antibody for IF, IHC - ABIN361882 : Sato, Fujita, Tsuruo: Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. in The Journal of biological chemistry 2002 (PubMed)
Show all 6 Pubmed References
Human Polyclonal PDPK1 Primary Antibody for IF, IHC - ABIN362492 : Lim, Kikani, Wick, Dong: Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
Show all 6 Pubmed References
Human Monoclonal PDPK1 Primary Antibody for ICS - ABIN1177136 : Komander, Kular, Deak, Alessi, van Aalten: Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding. in The Journal of biological chemistry 2005 (PubMed)
Human Monoclonal PDPK1 Primary Antibody for ICS - ABIN1177137 : Wick, Ramos, Chen, Quon, Dong, Liu: Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop. in The Journal of biological chemistry 2003 (PubMed)

More Antibodies against PDPK1 Interaction Partners

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

miR (show MYLIP Antibodies)-375 directly targeted PDK1 (show PDK1 Antibodies) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

Our experimental results suggested that PDK1 (show PDK1 Antibodies) may promote chondrocyte apoptosis in osteoarthritis via p38 MAPK (show MAPK14 Antibodies) signaling pathway
ATP5G1 (show ATP5G1 Antibodies), ATP5G2 (show ATP5G2 Antibodies), and ATP5G3 (show ATP5G3 Antibodies) of the ATP synthase are not involved in forming the permeability transition pore.
our results offer significant insight into how PIK3CA (show PIK3CA Antibodies) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (show PIK3CA Antibodies)/PDK1 (show PDK1 Antibodies) and TGFb (show TGFB1 Antibodies) signaling in advanced HNSCC patients with PIK3CA (show PIK3CA Antibodies) amplification
Ribociclib, in combination with GSK2334470 or the PI3Kalpha (show PIK3CA Antibodies) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (show PIK3CA Antibodies)-PDK1 (show PDK1 Antibodies) signaling pathway in mediating acquired resistance to CDK4/6 (show CDK4 Antibodies) inhibitors.
Decreased PDK1 (show PDK1 Antibodies) protein expression in A2058 cells.
Together these results indicate a strong potential regulatory role for PDK1 (show PDK1 Antibodies) in OC stimulatory pathways (Akt (show AKT1 Antibodies), ERK (show EPHB2 Antibodies)) and autophagy induction (via mTORC1), which may contribute to the OC phenotype in Paget's disease of bone.
It targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT (show AKT1 Antibodies).
High (show PDK1 Antibodies)ly expressed PDK1 could promote cell invasion and secretion of IL-1beta and IL-6 in human rheumatoid arthritis s (show PDK1 Antibodies)ynovial (show PDK1 Antibodies)MH7A c (show RPS6KA3 Antibodies)ells. Inhib (show RPS6KA3 Antibodies)ition of RSK2 reduced the PDK (show ASF1A Antibodies)1-induced cell invasion and cytokines secretion (show PDK1 Antibodies) in M (show RPS6KA3 Antibodies)H7A cells. In response to TNF-alpha, PDK1 could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB.
In cancer cells resistant to PI3Kalpha (show PIK3CA Antibodies) inhibition, PDK1 (show PDK1 Antibodies) blockade restores sensitivity to these therapies. SGK1 (show SGK1 Antibodies), which is activated by PDK1 (show PDK1 Antibodies), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (show TSC2 Antibodies).
Results suggest that Ser (show SIGLEC1 Antibodies)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (show PDK1 Antibodies)-PKCtheta (show PRKCQ Antibodies);-mediated T cell activation.

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

our results offer significant insight into how PIK3CA (show PIK3CA Antibodies) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 and TGFb (show TGFB1 Antibodies) signaling in advanced HNSCC patients with PIK3CA (show PIK3CA Antibodies) amplification
PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of asymmetric cell division and the Notch (show NOTCH1 Antibodies)-dependent differentiation program.
Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.
PDK1 was highly expressed in synovia of collagen-induced-arthritis mice compared to control. The expressions of PDK1, p-PDK1, RSK2 (show RPS6KA3 Antibodies) and p-RSK2 (show RPS6KA3 Antibodies) were all up-regulated in CIA (show NCOA5 Antibodies) compared with normal. This indicated that PDK1/RSK2 (show RPS6KA3 Antibodies) may participate in inflammatory progress of RA.
PDK1 is required for Ca(2 (show CA2 Antibodies)+)-dependent platelet activation on stimulation of collagen receptor (show ITGA2 Antibodies) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.
In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Antibodies)/PDPK1/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1. This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati
Only when suboptimal doses of Akt (show AKT1 Antibodies)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 Antibodies) inhibition was seen. We conclude that the Akt (show AKT1 Antibodies) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 Antibodies) signaling.
Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (show NFKB1 Antibodies).
PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.
The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

The authors show that loss of frataxin homolog (fh (show FXN Antibodies)) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2 (show MYEF2 Antibodies)).
PDK1 is also a presynaptic protein, though it is distributed more broadly.
dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (show CDK7 Antibodies) 1, dPDK1

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 Antibodies) (PI3K)

Arabidopsis thaliana 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
PDK1 (show PDK1 Antibodies) undergoes autophosphorylation at several sites; mutation of Ser (show SIGLEC1 Antibodies)-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp (show ASIP Antibodies)-167, Thr (show TRH Antibodies)-176, & Thr (show TRH Antibodies)-211
PDK1 (show PDK1 Antibodies) is a potent enhancer of PID (show MTA2 Antibodies) activity.
specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis

PDPK1 Antigen Profile

Antigen Summary

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.

Alternative names and synonyms associated with PDPK1

3-phosphoinositide dependent protein kinase 1 (PDPK1) antibody
3-phosphoinositide dependent protein kinase 1 L homeolog (pdpk1.L) antibody
3-phosphoinositide dependent protein kinase 1 (pdpk1) antibody
3-phosphoinositide dependent protein kinase-1 (Pdpk1) antibody
3-phosphoinositide dependent protein kinase 1 (Pdpk1) antibody
ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) (ATP5G2) antibody
3-phosphoinositide-dependent protein kinase 1 (LOC100380750) antibody
pyruvate dehydrogenase kinase, isozyme 1 (pdk1) antibody
pyruvate dehydrogenase kinase 1 (PDK1) antibody
Phosphoinositide-dependent kinase 1 (Pdk1) antibody
3-phosphoinositide-dependent protein kinase 1 (pdk-1) antibody
pyruvate dehydrogenase kinase 1 (Pdk1) antibody
3'-phosphoinositide-dependent protein kinase 1 (PDK1) antibody
3-phosphoinositide dependent protein kinase 1b (pdpk1b) antibody

3'-phosphoinositide-dependent protein kinase 1 antibody
3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 antibody
1210 antibody
ATP5A antibody
AtPDK1 antibody
BG02759 antibody
CG1201 antibody
CG1210 antibody
Dmel\\CG1210 antibody
dPDK-1 antibody
dPDK1 antibody
dSTPK61 antibody
MGC82080 antibody
PDK antibody
PDK-1 antibody
Pdk1 antibody
PDK1/Pk61C antibody
pdpk1 antibody
PDPK2 antibody
pk61c antibody
Pk61C/PDK1 antibody
PRO0461 antibody
si:zfos-979f1.3 antibody
T32M21.110 antibody
T32M21_110 antibody
zgc:77318 antibody

Protein level used designations for PDPK1

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 3-phosphoinositide-dependent protein kinase 1 3-phosphoinositide dependent protein kinase-1 pkB kinase protein kinase B kinase PkB kinase like gene 1 Pkb kinase mPDK1 ATP synthase c subunit ATP synthase lipid-binding protein, mitochondrial ATP synthase proteolipid P2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) ATPase protein 9 ATPase subunit C mitochondrial ATP synthase, subunit C (subunit 9) CG1210-PA CG1210-PB CG1210-PC CG1210-PD CG1210-PE CG1210-PF CG1210-PG CG1210-PH CG1210-PI CG1210-PJ Pdk1-PA Pdk1-PB Pdk1-PC Pdk1-PD Pdk1-PE Pdk1-PF Pdk1-PG Pdk1-PH Pdk1-PI Pdk1-PJ phosphoinositide dependent kinase 1 phosphoinositide-dependent kinase 1 protein kinase 61C serine/threonine protein kinase pyruvate dehydrogenase kinase 1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

GENE ID	SPECIES
416588	Gallus gallus
444529	Xenopus laevis
479875	Canis lupus familiaris
100138102	Bos taurus
100192445	Sus scrofa
779524	Xenopus (Silurana) tropicalis
81745	Rattus norvegicus
5170	Homo sapiens
18607	Mus musculus
517	Homo sapiens
100380750	Salmo salar
555840	Danio rerio
100064091	Equus caballus
38017	Drosophila melanogaster
180475	Caenorhabditis elegans
100351323	Oryctolagus cuniculus
100715937	Cavia porcellus
101117211	Ovis aries musimon
830330	Arabidopsis thaliana
403000	Danio rerio

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Show all anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antibodies with Pubmed References