Browse our PIK3R5 Proteins (PIK3R5)

Full name:: Phosphoinositide-3-Kinase, Regulatory Subunit 5 Proteins (PIK3R5)

On www.antibodies-online.com are 3 Phosphoinositide-3-Kinase, Regulatory Subunit 5 (PIK3R5) Proteins from 2 different suppliers available. Additionally we are shipping PIK3R5 Antibodies (75) and many more products for this protein. A total of 84 PIK3R5 products are currently listed.

Synonyms:: AV230647, F730038I15Rik, FOAP-2, P101, P101-PI3K, RGD1563261

list all proteins	Gene Name	GeneID	UniProt
	PIK3R5	23533	Q8WYR1
Rat PIK3R5	PIK3R5	497931
	PIK3R5	320207	Q5SW28
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Human Phosphoinositide-3-Kinase, Regulatory Subunit 5 (PIK3R5) interaction partners

data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma (show PIK3CG Proteins) activation.
PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma.
expression and activities of PI3Kgamma (show PIK3CG Proteins) are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma (show PIK3CG Proteins) signaling pathways.
Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis.
p101 has a role in membrane recruitment and activation of PI3K gamma (show PIK3CG Proteins)
analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma
Overexpression of p101 activates PI3Kgamma (show PIK3CG Proteins) signaling and is associated with T-cell lymphomas

PIK3R5 Protein Profile

Protein Summary

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.

Alternative names and synonyms associated with PIK3R5

phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5)
phosphoinositide-3-kinase regulatory subunit 5 S homeolog (pik3r5.S)
phosphoinositide-3-kinase, regulatory subunit 5 (Pik3r5)
phosphoinositide-3-kinase regulatory subunit 5 (Pik3r5)

AV230647 protein
F730038I15Rik protein
FOAP-2 protein
P101 protein
P101-PI3K protein
RGD1563261 protein

Protein level used designations for PIK3R5

PI3-kinase regulatory subunit 5 , phosphoinositide-3-kinase, regulatory subunit 5, p101 , PI3-kinase p101 subunit , phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit , phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit , phosphoinositide 3-kinase regulatory subunit 5 , protein FOAP-2 , ptdIns-3-kinase p101 , Phosphoinositide 3-kinase regulatory subunit 5 , IB PI3-kinase p101 subunit , p101-PI3K , ptdIns-3-kinase regulatory subunit

GENE ID	SPECIES
417319	Gallus gallus
23533	Homo sapiens
432272	Xenopus laevis
612805	Canis lupus familiaris
396851	Sus scrofa
614838	Bos taurus
497931	Rattus norvegicus
320207	Mus musculus

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