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Our findings suggest that p84 (show PPP1R12C Proteins) binding to p110gamma (show PIK3CG Proteins) may represent a novel negative feedback signal that terminates PI3Kgamma (show PIK3CG Proteins) activity.
expression and activities of PI3Kgamma (show PIK3CG Proteins) are modified differently by p87 and p101 (show PIK3R5 Proteins) in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma (show PIK3CG Proteins) signaling pathways.
knockdown of p84 (show PPP1R12C Proteins) in MDA-MB-231 cells enhanced Akt (show AKT1 Proteins) phosphorylation and lung colonization
GPCR (show NMUR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
ablation of PI3Kgamma (show PIK3CG Proteins) reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
RACK1 (show GNB2L1 Proteins) regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC (show HSPG2 Proteins) beta and PI3K gamma (show PIK3CG Proteins)
These data demonstrate PI3Kgamma (show PIK3CG Proteins)-dependent signalling downstream of IL-17RA (show IL17RA Proteins), which plays a pivotal role in regulating IL-17 (show IL17A Proteins) production in T cells.
GPCR (show GPBAR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
that genetic deletion of PI3Kgamma (show PIK3CG Proteins) enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2 (show F2RL1 Proteins))-dependent itch.
PI3Kgamma (show PIK3CG Proteins) has a role in the induction of CXCR3 (show CXCR3 Proteins) on T cells
Results suggest that the CXCR2 (show CXCR2 Proteins) and PI3Kgamma (show PIK3CG Proteins) signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage.
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors.
PI3Kgamma adapter protein of 87 kDa
, p84 PI3K adapter protein
, p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
, phosphoinositide 3-kinase regulatory subunit 6
, p87 PI3K adapter protein
, phosphoinositide 3-kinase gamma adapter protein of 87 kDa
, p87 phosphoinositide 3-kinase gamma adapter