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Full name:: Phosphoinositide-3-Kinase, Regulatory Subunit 6 Proteins (PIK3R6)

On www.antibodies-online.com are 4 Phosphoinositide-3-Kinase, Regulatory Subunit 6 (PIK3R6) Proteins from 2 different suppliers available. Additionally we are shipping PIK3R6 Antibodies (14) and many more products for this protein. A total of 21 PIK3R6 products are currently listed.

Synonyms:: BB220380, C17orf38, HsT41028, p84, p84 PIKAP, p87(PIKAP), p87PIKAP, RGD1560850

list all proteins	Gene Name	GeneID	UniProt
	PIK3R6	146850	Q5UE93
	PIK3R6	104709	Q3U6Q4
Rat PIK3R6	PIK3R6	497932
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Human Phosphoinositide-3-Kinase, Regulatory Subunit 6 (PIK3R6) interaction partners

Our findings suggest that p84 (show PPP1R12C Proteins) binding to p110gamma (show PIK3CG Proteins) may represent a novel negative feedback signal that terminates PI3Kgamma (show PIK3CG Proteins) activity.
expression and activities of PI3Kgamma (show PIK3CG Proteins) are modified differently by p87 and p101 (show PIK3R5 Proteins) in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma (show PIK3CG Proteins) signaling pathways.
knockdown of p84 (show PPP1R12C Proteins) in MDA-MB-231 cells enhanced Akt (show AKT1 Proteins) phosphorylation and lung colonization
GPCR (show NMUR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
ablation of PI3Kgamma (show PIK3CG Proteins) reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
RACK1 (show GNB2L1 Proteins) regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC (show HSPG2 Proteins) beta and PI3K gamma (show PIK3CG Proteins)

Mouse (Murine) Phosphoinositide-3-Kinase, Regulatory Subunit 6 (PIK3R6) interaction partners

These data demonstrate PI3Kgamma (show PIK3CG Proteins)-dependent signalling downstream of IL-17RA (show IL17RA Proteins), which plays a pivotal role in regulating IL-17 (show IL17A Proteins) production in T cells.
GPCR (show GPBAR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
that genetic deletion of PI3Kgamma (show PIK3CG Proteins) enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2 (show F2RL1 Proteins))-dependent itch.
p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
ablation of PI3Kgamma (show PIK3CG Proteins) reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
PI3Kgamma (show PIK3CG Proteins) has a role in the induction of CXCR3 (show CXCR3 Proteins) on T cells
Results suggest that the CXCR2 (show CXCR2 Proteins) and PI3Kgamma (show PIK3CG Proteins) signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage.

PIK3R6 Protein Profile

Protein Summary

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors.

Alternative names and synonyms associated with PIK3R6

phosphoinositide-3-kinase regulatory subunit 6 (PIK3R6)
phosphoinositide-3-kinase regulatory subunit 5 (Pik3r6)
phosphoinositide-3-kinase regulatory subunit 6 (Pik3r6)
phosphoinositide-3-kinase, regulatory subunit 6 (Pik3r6)

BB220380 protein
C17orf38 protein
HsT41028 protein
p84 protein
p84 PIKAP protein
p87(PIKAP) protein
p87PIKAP protein
RGD1560850 protein

Protein level used designations for PIK3R6

PI3Kgamma adapter protein of 87 kDa , p84 PI3K adapter protein , p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein , phosphoinositide 3-kinase regulatory subunit 6 , p87 PI3K adapter protein , phosphoinositide 3-kinase gamma adapter protein of 87 kDa , p87 phosphoinositide 3-kinase gamma adapter

GENE ID	SPECIES
146850	Homo sapiens
104709	Mus musculus
100729521	Cavia porcellus
497932	Rattus norvegicus
515621	Bos taurus

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