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Browse our PITRM1 Proteins (PITRM1)

Full name:: Pitrilysin Metallopeptidase 1 Proteins (PITRM1)

On www.antibodies-online.com are 8 Pitrilysin Metallopeptidase 1 (PITRM1) Proteins from 5 different suppliers available. Additionally we are shipping PITRM1 Antibodies (64) and PITRM1 Kits (4) and many more products for this protein. A total of 80 PITRM1 products are currently listed.

Synonyms:: 2310012C15Rik, AA410010, mKIAA1104, MP-1, MP1, Ntup1, PITRM1, PreP, wu:fa03d09, zgc:55469

list all proteins	Gene Name	GeneID	UniProt
	PITRM1	10531	Q5JRX3
	PITRM1	69617	Q8K411
	PITRM1	307081
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PI3K-Akt Signaling

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Human Pitrilysin Metallopeptidase 1 (PITRM1) interaction partners

Mutational disruption of electrostatic interactions in proximity of Pitrm1 arginine 183 residue contributes to the loss of enzyme activity.The arginine-to-glutamine substitution mutant Pitrm1 R183Q has been implicated in inherited amyloidogenic neuropathy.
Redox control of hPreP in the mitochondrial matrix and the protective role of the conserved methionine 206 residue as an internal antioxidant.
The authors identified two siblings carrying a homozygous PITRM1 missense mutation (c.548G>A, p.Arg183Gln) associated with an autosomal recessive, slowly progressive syndrome characterised by mental retardation, spinocerebellar ataxia, cognitive decline and psychosis.
Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria.
This study demonstrated decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria.
our data suggest that genetic variation in the hPreP gene PITRM1 may potentially contribute to mitochondrial dysfunctions
The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified.
Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease.

Mouse (Murine) Pitrilysin Metallopeptidase 1 (PITRM1) interaction partners

results suggest that pitrilysin regulates islet amyloid polypeptide in beta cells and suggest the presence of an intramitochondrial pool of islet amyloid polypeptide involved in beta-cell apoptosis.
Pitrm1 is expressed in Pax3-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.

PITRM1 Protein Profile

Protein Summary

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.

Alternative names and synonyms associated with PITRM1

pitrilysin metallopeptidase 1 (PITRM1)
pitrilysin metallepetidase 1 (Pitrm1)
pitrilysin metallopeptidase 1 (Pitrm1)
pitrilysin metallopeptidase 1 L homeolog (pitrm1.L)
pitrilysin metallopeptidase 1 (pitrm1)

2310012C15Rik protein
AA410010 protein
mKIAA1104 protein
MP-1 protein
MP1 protein
Ntup1 protein
PITRM1 protein
PreP protein
wu:fa03d09 protein
zgc:55469 protein

Protein level used designations for PITRM1

PreP peptidasome , metalloprotease 1 (pitrilysin family) , pitrilysin metalloproteinase 1 , presequence protease, mitochondrial , nuclear transplantation upregulated protein 1 , pitrilysin metalloprotease 1 , pitrilysin metallepetidase 1 , Pitrilysin metalloproteinase 1 , metalloprotease 1

GENE ID	SPECIES
10531	Homo sapiens
69617	Mus musculus
307081	Rattus norvegicus
100189669	Pongo abelii
379672	Xenopus laevis
406808	Danio rerio
100723006	Cavia porcellus
100070807	Equus caballus
478018	Canis lupus familiaris
513230	Bos taurus
100344768	Oryctolagus cuniculus

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