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AG1024+U0126 acted synergistically to downregulate "synergy" genes, especially STAT6 and PDAP1, which displayed significant expression codependency and a common expression pattern linked with other key "synergy" genes, supporting their predicted role in an STAT6-ERK-nuclear factor kappa beta (NF-kappaB) network. Daunorubicin and PDAP1 loss were synergistic, so PDAP1 is important for the response to this anthracycline.
PDAP-1 as an effecter of PDGF signaling in glioma cells
The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity.
28 kDa heat- and acid-stable phosphoprotein
, pdgfa associated protein 1
, PDGF-associated protein
, PDGFA-associated protein 1
, heat- and acid-stable phosphoprotein of 28 kDa
, kinase substrate HASPP28