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His596 is involved in anchoring the carboxy terminal of arachidonic acid during catalysis, while Leu407 is involved in positioning the substrate correctly.
5-LOX does not react with 5,15-diHpETE, although it can produce lipoxin A4 when 15-HpETE is the substrate. In contrast, both 12-LOX and 15-LOX-1 react with 5,15-diHpETE, forming specifically lipoxin B4.
The results suggested that genetic variation in ALOX12 might influence BMD variations in our recruited participants. As for the patients with lower serum Se levels, it was observed that serum Se deficiency was accompanied by some ALOX12 variation, contributing to the development of osteoporosis.
ALOX12 missense mutations from human cancers abrogate its ability to oxygenate polyunsaturated fatty acids and to induce p53-mediated ferroptosis. Notably, ALOX12 is dispensable for ferroptosis induced by erastin or GPX4 inhibitors; conversely, ACSL4 is required for ferroptosis upon GPX4 inhibition but dispensable for p53-mediated ferroptosis
this study has revealed previously uncharacterized metabolic reprogramming involving an ALOX12-12-HETE-GPR31 axis that functionally determines hepatic ischemia-reperfusion injury procession
This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases. [Review]
ALOX15 orthologs, commonly known as 12/15-lipoxygenases, were suggested to exhibit mainly arachidonic acid 12-lipoxygenating specificity in mammals ranked in evolution lower than gibbons and 15-lipoxygenating specificity in the higher ranking primates [Review].
ALOX12 rs14309 GG genotype expression was found to be significantly associated with Cardiovascular events in patients with Diabetic Nephropathy.
Data suggest that ALOX12 is involved in oxidative stress and endoplasmic reticulum stress in liver and other tissues leading to non-alcoholic fatty liver disease. [REVIEW]
12(S)-HETrE, a 12-lipoxygenase oxylipin of dihomo-gamma-linolenic acid, inhibits thrombosis via Galphas signaling in platelets.
Results identified a novel ALOX12 locus (indicated by two SNPs in perfect linkage disequilibrium: rs1042357 and rs10852889) that moderated the association between PTSD and reduced thickness of the right prefrontal cortex.
The regulation of important oxylipin metabolic genes in peripheral blood mononuclear cells varied with the extent of change in arachidonic acid concentrations in the case of PTGS1 and ALOX12 regulation.
ITGB4 stimulation leads to recruitment of 12-LOX from the cytosol to the membrane.
In the highest tertile with ALOX12.
the amount of LPL expressed in muscle and heart governed both the binding of chylomicron particles and the assimilation of chylomicron lipids in the tissue.
Results suggest that Alox12 protein polymorphisms did not discriminate for psoriasis severity.
Results indicate that secreted phospholipase A2 IIA (sPLA2-IIA) as an enzyme working in concert with platelet microparticles (MPs) 12-lipoxygenase (12-LO) to promote internalization.
IGF-1 reduces lipid oxidation and foam cell formation via downregulation of 12/15-LOX to prevent atherosclerosis.
The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease
The costaining of pancreatic polypeptide and vimentin suggests that 12-LO participates in the process leading to beta-cell dedifferentiation in the islet.
these results indicate that Alox12 loss activates a compensatory increase in Alox15 that sensitizes mouse beta cells to oxidative stress.
Data show that the coordinated action of phospholipase A2 IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO) promotes inflammatory arthritis.
Data indicate that 12/15-LO knockout (KO) mice were protected from high fat (HF) diet with high dietary omega6/omega3 ratio (11ratio1, HFH)-induced fatty liver.
These results suggest that cardiac 12/15-LOX-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy and that inhibition of 12/15-LOX could be a novel treatment for this condition.
EET-heme oxygenase-1 crosstalk as an important cytoprotective mechanism in the amelioration of vascular and adipocyte dysfunction resulting from diet-induced obesity.
Overexpression of 15-lipoxygenase increases anxiety behavior in female mice.
Findings suggest 12/15-LOX expressed in non-epithelial cells such as macrophages and fibroblasts leads to bronchial epithelial injury.
Data indicate that intravenous injection of B16F10 melanoma cells caused lung nodule formation, which was markedly attenuated in 12/15-Lipoxygenase (12/15-LOX) null mice.
Following middle cerebral artery occlusion to induce stroke, immunohistochemistry shows both Sema3A and 12/15-LOX are increased in the cortex up to 2 wk.
ALOX12 may have a role in growth of breast cancer, and its inhibition may be a strategy for inhibiting tumor growth
IT delivery of 12-LOX metabolites of arachidonic acid 12(S)-HpETE, 12(S)-HETE, HXA(3), or HXB(3) evoked profound, persistent tactile allodynia, but 12(S)-HpETE and HXA(3) produced relatively modest, transient heat hyperalgesia
These data indicate that 12/15-LO and its metabolites have a prominent antifibrotic role during dermal fibrosis.
reduction of alox12 activity or expression could provide a new therapeutic target to reduce ER stress and
Arachidonic acid epoxygenase and 12(S)-lipoxygenase jointly produce a hitherto uncharacterized compound acting as oxygen messenger in the ductus arteriosus.
Increased expression of 12/15LO in the vessel wall enhances Id3-dependent cell proliferation, fibronectin deposition, and neointimal formation in response to carotid artery injury.
12/15-LOX and AIF are sequential actors in a common cell death pathway that may contribute to stroke-induced brain damage.
In the developing epidemis, DeltaNp63alpha directly induces the expression of Alox12, a gene involved in epidermal barrier formation, by interacting with a response element in the promoter of Alox12.
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity
, arachidonate 12-lipoxygenase, 12S-type
, platelet 12-LOX
, platelet-type 12-lipoxygenase
, platelet-type lipoxygenase 12
, arachidonate 12-lipoxygenase
, LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, 12S-type