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anti-Human CARD8 Antibodies:
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Human Polyclonal CARD8 Primary Antibody for ICC, ELISA - ABIN1001986
Scholl, McLoughlin, Ehler, de Giovanni, Schäfer: DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis. in The Journal of cell biology 2000
Show all 3 Pubmed References
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
caspase recruitment domain family, member 8
, CARD inhibitor of NF-kappaB-activating ligands
, apoptotic protein NDPP1
, caspase recruitment domain-containing protein 8
, tumor up-regulated CARD-containing antagonist of CASP9
, tumor up-regulated CARD-containing antagonist of caspase nine