CARD8 Products
(Caspase Recruitment Domain Family, Member 8 (CARD8))
Categories
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
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Featured CARD8 Categories
CARD8 Antibodies
High quality antibodies with extensive validation data.
CARD8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CARD8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7146923
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN6260461
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (2)
Cat. No.
ABIN524838
Quantity
100 μL
Datasheet
Datasheet
Recommended CARD8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6202321
Quantity
96 tests
Datasheet
Datasheet
Recommended CARD8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348057
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348059
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348061
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our CARD8 products
: "Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease." in: The Journal of clinical investigation, Vol. 128, Issue 5, pp. 1793-1806, (2018) (PubMed).: "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13952-8, (2002) (PubMed).
: "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation." in: FEBS letters, Vol. 521, Issue 1-3, pp. 165-9, (2002) (PubMed).
: "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32220-9, (2001) (PubMed).
: "DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis." in: The Journal of cell biology, Vol. 151, Issue 3, pp. 495-506, (2000) (PubMed).
: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." in: Immunity, Vol. 6, Issue 1, pp. 79-88, (1997) (PubMed).
: "LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 9, pp. 4615-9, (1997) (PubMed).
Synonyms and alternative names related to CARD8
caspase recruitment domain family, member 8 (CARD8), caspase recruitment domain-containing protein 8 (LOC718594), caspase recruitment domain family member 8 (CARD8), CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCANProtein level used designations for CARD8
- caspase recruitment domain family, member 8
- CARD inhibitor of NF-kappaB-activating ligands
- apoptotic protein NDPP1
- caspase recruitment domain-containing protein 8
- tumor up-regulated CARD-containing antagonist of CASP9
- tumor up-regulated CARD-containing antagonist of caspase nine
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