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this study showed that the CARD8-C10X (rs2043211) AT genotype contributed to the susceptibility of multiple myeloma
Our results showed that rs10754558 NLRP3 and rs2043211 CARD8 polymorphisms are associated with rheumatoid arthritis development (p value = 0.044, OR = 1.77, statistical power = 0.999) and severity measured by Health Assessment Questionnaire (HAQ) (p value = 0.03), respectively.
this study found that the AT genotype of CARD8 (rs2043211) was significantly higher compared to TT genotype in high and intermediate risk chronic myeloid leukemia patients
Review/Meta-analysis: CARD8 p.C10X SNP were not associated with the susceptibility to rheumatoid arthritis.
these results identify a new CARD8 variant associated with periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis, and further suggest that disruption of the interaction between CARD8 and NLRP3 can regulate autoinflammation in patients
The over expression of CARD8 due to higher promoter activity of the TT genotype may result in a dramatically inflammatory immune response and then increase the susceptibility to Arteriosclerosis Obliterans.
High CARD8 expression is associated with malignant melanoma.
The CARD8 rs2043211 genetic variants was not implicated in the development of gout in the male Korean population. However, we found that in a pair-wise comparison of the CA/TT P2X7R and CARD8 genotype combination was shown to have an increased trend for the risk of gout.
The NLRP3 rs10754558 gene polymorphism was significantly associated with the occurrence of CAD, while the CARD8 rs2043211 gene polymorphism was not involved.
In patients with ileal, stenotic or fistulizing Crohn's disease, the mutant-type CARD8 rs2043211 polymorphism may generate a potentially protective effect. (Meta-analysis)
There is evidence for association of gout with functional variants in CARD8, IL1B and CD14.
The polymorphism of rs2043211 in CARD8 may be a relevant host susceptibility factor for the development of preeclampsia in the Chinese Han population.
A novel association between CARD8 and increased risk of surgical recurrence in Crohn's disease was observed and CARD8 could be a new marker for risk stratification and prevention of recurrent surgery.
genetic polymorphism is associated with susceptibility to Crohn's disease under the dominant model and homozygote contrast in the European population; meta-analysis
Patients carrying genotype TT of CARD8 rs2043211 polymorphism had higher triglycerides levels compared to those carrying the AA genotype.
CARD8 might not play a role in the pathogenesis of Tourette syndrome in Chinese Han population
Data indicate 3 variants in 3 novel genes myc target 1 protein (MYCT1), caspase recruitment domain family member 8 (CARD8) and zinc finger protein 543 (ZNF543), associated with familial IgA nephropathy (IgAN).
we show that CARD8 plays a role as a negative regulator of NLRP3 inflammasome through its binding with NLRP3
levels of inflammasome-produced cytokines as a measure of inflammasome activation in healthy individuals carrying Q705K polymorphism in the NLRP3 gene combined with C10X in the CARD8 gene
ANRIL may increase the risk of ischemic stroke through regulation of the CARD8 pathway
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
caspase recruitment domain family, member 8
, CARD inhibitor of NF-kappaB-activating ligands
, apoptotic protein NDPP1
, caspase recruitment domain-containing protein 8
, tumor up-regulated CARD-containing antagonist of CASP9
, tumor up-regulated CARD-containing antagonist of caspase nine