Browse our CARD8 Proteins (CARD8)

Full name:: Caspase Recruitment Domain Family, Member 8 Proteins (CARD8)

On www.antibodies-online.com are 5 Caspase Recruitment Domain Family, Member 8 (CARD8) Proteins from 0 different suppliers available. A total of 101 CARD8 products are currently listed.

Synonyms:: CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN

list all proteins	Gene Name	GeneID	UniProt
Human CARD8	CARD8	22900	Q9Y2G2
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Relevant Pathways for CARD8 Proteins

Positive Regulation of Endopeptidase Activity

More product categories related to CARD8 Protein

More Proteins for CARD8 Interaction Partners

Human Caspase Recruitment Domain Family, Member 8 (CARD8) interaction partners

Review/Meta-analysis: CARD8 p.C10X SNP were not associated with the susceptibility to rheumatoid arthritis.
these results identify a new CARD8 variant associated with periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis, and further suggest that disruption of the interaction between CARD8 and NLRP3 (show NLRP3 Proteins) can regulate autoinflammation in patients
The over expression of CARD8 due to higher promoter activity of the TT genotype may result in a dramatically inflammatory immune response and then increase the susceptibility to Arteriosclerosis Obliterans.
High CARD8 expression is associated with malignant melanoma.
The CARD8 rs2043211 genetic variants was not implicated in the development of gout in the male Korean population. However, we found that in a pair-wise comparison of the CA/TT P2X7R (show P2RX7 Proteins) and CARD8 genotype combination was shown to have an increased trend for the risk of gout.
The NLRP3 (show NLRP3 Proteins) rs10754558 gene polymorphism was significantly associated with the occurrence of CAD, while the CARD8 rs2043211 gene polymorphism was not involved.
In patients with ileal, stenotic or fistulizing Crohn's disease, the mutant-type CARD8 rs2043211 polymorphism may generate a potentially protective effect. (Meta-analysis)
There is evidence for association of gout with functional variants in CARD8, IL1B (show IL1B Proteins) and CD14 (show NDUFA2 Proteins).
The polymorphism of rs2043211 in CARD8 may be a relevant host susceptibility factor for the development of preeclampsia in the Chinese Han population.
A novel association between CARD8 and increased risk of surgical recurrence in Crohn's disease was observed and CARD8 could be a new marker for risk stratification and prevention of recurrent surgery.

CARD8 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.

Alternative names and synonyms associated with CARD8

caspase recruitment domain family, member 8 (CARD8)
caspase recruitment domain-containing protein 8 (LOC718594)
caspase recruitment domain family member 8 (CARD8)

CARD8 protein
CARDINAL protein
DACAR protein
DAKAR protein
NDPP protein
NDPP1 protein
TUCAN protein

Protein level used designations for CARD8

caspase recruitment domain family, member 8 , CARD inhibitor of NF-kappaB-activating ligands , apoptotic protein NDPP1 , caspase recruitment domain-containing protein 8 , tumor up-regulated CARD-containing antagonist of CASP9 , tumor up-regulated CARD-containing antagonist of caspase nine

GENE ID	SPECIES
456176	Pan troglodytes
718594	Macaca mulatta
22900	Homo sapiens
100172562	Pongo abelii

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