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anti-Human NLRP1 Antibodies:
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Human Polyclonal NLRP1 Primary Antibody for ICC, IF - ABIN4890403
Fahy, Exline, Gavrilin, Bhatt, Besecker, Sarkar, Hollyfield, Duncan, Nagaraja, Knatz, Hall, Wewers: Inflammasome mRNA expression in human monocytes during early septic shock. in American journal of respiratory and critical care medicine 2008
Show all 5 Pubmed References
Human Polyclonal NLRP1 Primary Antibody for IF, WB - ABIN541194
Chu, Pio, Xie, Welsh, Krajewska, Krajewski, Godzik, Reed: A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. in The Journal of biological chemistry 2001
Show all 3 Pubmed References
Human Monoclonal NLRP1 Primary Antibody for IF, IHC (p) - ABIN535031
Dai, Sayama, Tohyama, Shirakata, Hanakawa, Tokumaru, Yang, Hirakawa, Hashimoto: Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes. in The Journal of allergy and clinical immunology 2011
Human Monoclonal NLRP1 Primary Antibody for ICC, IF - ABIN4340089
Kummer, Broekhuizen, Everett, Agostini, Kuijk, Martinon, van Bruggen, Tschopp: Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007
the NLRP1 inflammasome is a key negative regulator of protective, butyrate-producing commensals, which therefore promotes inflammatory bowel disease
not associated with obesity in this study
eight single nucleotide polymorphisms, four from NLRP1 (rs8079034, rs11651270, rs11657747, and rs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with Psoriasis Vulgaris and 612 healthy controls in the Chinese Han population, were genotyped.
the analysis of multiple sclerosis (MS) patients from Canada failed to identify potentially pathogenic mutations in NLRP1, including the previously described p.G587S mutation. Further studies are necessary to confirm a role of NLRP1 in the pathophysiology of MS.
Suggest inflammasome protein NLRP1 appears to have a specific role in the development of occlusive aortic disease.
Based on the data obtained from patients and in vitro cells, we concluded that both NLRP1 and NLRP3 inflammasomes are highly involved in the FLS inflammation and pyroptosis.
NLRP1 promotes cell line MCF-7 the proliferation, migration, and invasion through inducing EMT.
The changes in the nucleotide-binding oligomerization domain-like receptors (NLRs) in human corneas with disease expression may reflect different susceptibility to infectious and non-infectious injuries in corneas with various diseases.
The CC genotype of NLRP1 rs878329 and TT genotype of PADI4 rs2240340 were associated with Rheumatoid Arthritis susceptibility in Asians.
study results suggest variations in the inflammasome, particularly in NLRP1 and CARD11, may be associated with chronic Chagas cardiomyopathy
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 1 and 3 (NLRP1 and NLRP3) inflammasomes and induced the release of IL-1beta and pyroptosis via a caspase-1-related mechanism in human periodontal ligament cells (HPDLCs).
Our study demonstrated the potentially significant role of NLRP1 rs878329 (G>C) in developing susceptibility to the partial seizures in a Chinese Han population
mRNA expression levels of NLRP1 and NLRC4 were not altered in chronic hepatitis B patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients.
NLRP1 senses cellular infection by distinct invasive pathogens.
NLRP1 promotes melanoma growth by enhancing inflammasome activation and suppressing apoptotic pathways.
Two new mutations in NLRP1 (c.3641C>G, p.Pro1214Arg and c.2176C>T; p.Arg726Trp) were found to cause a new autoinflammatory syndrome, NLRP1-associated autoinflammation with arthritis and dyskeratosis.
Th17 micro-milieu via IL-17A regulates NLRP1-dependent CASP5 activity in psoriatic skin autoinflammation.
HO-1 inhibited expression of activating transcription factor 4 (ATF4), which is a transcription factor regulating NLRP1 expression
Simvastatin intake in peripheral arterial disease patients increases in vitro reactivity of NLRP1 inflammasome gene expression in endothelial cells.
these findings establish a group of non-fever inflammasome disorders, uncover an unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence linking NLRP1 to skin inflammatory syndromes and skin cancer predisposition.
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
NACHT, LRR and PYD containing protein 1
, NACHT, LRR and PYD domains-containing protein 1
, NACHT, leucine rich repeat and PYD (pyrin domain) containing 1
, NACHT, leucine rich repeat and PYD containing 1
, caspase recruitment domain protein 7
, caspase recruitment domain-containing protein 7
, death effector filament-forming Ced-4-like apoptosis protein
, nucleotide-binding domain and caspase recruitment domain
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
, NLR family, pyrin domain containing 1
, NLR family pyrin domain containing 1