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anti-Human NLRP1 Antibodies:
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Human Polyclonal NLRP1 Primary Antibody for ICC, IF - ABIN4890403
Fahy, Exline, Gavrilin, Bhatt, Besecker, Sarkar, Hollyfield, Duncan, Nagaraja, Knatz, Hall, Wewers: Inflammasome mRNA expression in human monocytes during early septic shock. in American journal of respiratory and critical care medicine 2008
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Human Monoclonal NLRP1 Primary Antibody for ICC, IF - ABIN4340089
Kummer, Broekhuizen, Everett, Agostini, Kuijk, Martinon, van Bruggen, Tschopp: Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007
eight single nucleotide polymorphisms, four from NLRP1 (rs8079034, rs11651270, rs11657747, and rs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with Psoriasis Vulgaris and 612 healthy controls in the Chinese Han population, were genotyped.
the analysis of multiple sclerosis (MS) patients from Canada failed to identify potentially pathogenic mutations in NLRP1, including the previously described p.G587S mutation. Further studies are necessary to confirm a role of NLRP1 in the pathophysiology of MS.
Suggest inflammasome protein NLRP1 appears to have a specific role in the development of occlusive aortic disease.
Based on the data obtained from patients and in vitro cells, we concluded that both NLRP1 and NLRP3 inflammasomes are highly involved in the FLS inflammation and pyroptosis.
NLRP1 promotes cell line MCF-7 the proliferation, migration, and invasion through inducing EMT (show ITK Antibodies).
The CC genotype of NLRP1 rs878329 and TT genotype of PADI4 (show PADI4 Antibodies) rs2240340 were associated with Rheumatoid Arthritis susceptibility in Asians.
study results suggest variations in the inflammasome, particularly in NLRP1 and CARD11 (show CARD11 Antibodies), may be associated with chronic Chagas cardiomyopathy
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin (show MEFV Antibodies) domain 1 and 3 (NLRP1 and NLRP3 (show NLRP3 Antibodies)) inflammasomes and induced the release of IL-1beta (show IL1B Antibodies) and pyroptosis via a caspase-1 (show CASP1 Antibodies)-related mechanism in human periodontal ligament cells (HPDLCs).
Our study demonstrated the potentially significant role of NLRP1 rs878329 (G>C) in developing susceptibility to the partial seizures in a Chinese Han population
mRNA expression levels of NLRP1 and NLRC4 (show NLRC4 Antibodies) were not altered in chronic hepatitis B patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients.
NLRP1 deficiency protects against cardiomyocyte hypertrophy induced by isoproterenol (PE); this protective activity was associated with the arrest of MAPK (show MAPK1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling.
Curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta (show IL1B Antibodies) by inhibiting the aggregation of NALP1 inflammasome and the activation of the JAK2 (show JAK2 Antibodies)-STAT3 (show STAT3 Antibodies) cascade in astrocytes.
The findings indicate that NLRP1 inflammasome activation does not significantly contribute to acute neural injury in the murine model of moderate CCI injury.
the aim of this study was to evaluate the effects of chronic dexamethasone (DEX) treatment on nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 1 (show PYDC1 Antibodies) (NLRP-1) inflammasome in male mice.
NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18 (show IL18 Antibodies), preventing obesity and metabolic syndrome.
these data identify NLRP1 as an essential mediator of the host immune response during IBD and cancer.
Data show that eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 (show CASP1 Antibodies) activation by the NLR (show CXCR5 Antibodies) family leucine-rich repeat protein (show LRRC10 Antibodies) (NLRP)1 and NLRP3 (show NLRP3 Antibodies) inflammasomes.
The NOD-like receptor NLRP1a/Caspase-1 (show CASP1 Antibodies) pathway is the best candidate to mediate the parasite-induced cell death.
Caspase-8 (show CASP8 Antibodies) promotes NLRP1/NLRP3 (show NLRP3 Antibodies) inflammasome activation and IL-1beta (show IL1B Antibodies) production in acute glaucoma.
These findings reveal Toxoplasma gondii as a novel activator of the NLRP1 and NLRP3 (show NLRP3 Antibodies) inflammasomes in vivo and establish a role for these sensors in host resistance to toxoplasmosis.
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
NACHT, LRR and PYD containing protein 1
, NACHT, LRR and PYD domains-containing protein 1
, NACHT, leucine rich repeat and PYD (pyrin domain) containing 1
, NACHT, leucine rich repeat and PYD containing 1
, caspase recruitment domain protein 7
, caspase recruitment domain-containing protein 7
, death effector filament-forming Ced-4-like apoptosis protein
, nucleotide-binding domain and caspase recruitment domain
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
, NLR family, pyrin domain containing 1
, NLR family pyrin domain containing 1