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Zebrafish Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1) interaction partners

Human Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1) interaction partners

1. Healthy human eosinophils express functional P2X1 receptors whose activation leads to eosinophil alphaMbeta2 integrin-dependent adhesion. P2X1 responses are constitutively reduced in asthmatic compared with healthy eosinophils, probably as the result of an increase in extracellular nucleotide concentration.

2. the expression of P2X1 transcript and its splicing variant P2X1del in most human monocytes

3. These data suggest that vascular smooth muscle cells from human gastro-omental arteries express P2X1 and P2X4 (show P2RX4 Proteins) receptor subunits

4. enhances platelet activation evoked by mild stimulants via the p38 (show CRK Proteins) signalling pathway

5. In conclusion, our results demonstrate for the first time that adenine nucleotides acting at P2X1 receptors inhibit the proliferation of human coronary smooth muscle cells via the induction of the early gene NR4A1 (show NR4A1 Proteins).

6. With the development of leukemia, the expression of P2X7R (show P2RX7 Proteins) increased in both bone marrow and spleen macrophages whereas expression of P2X1 Receptor increased in spleen macrophages.

7. Increased P2X1 receptor expression and ATP release may have contributed to the augmentation of contractile response induced by hypoxia-glucopenia and reoxygenation in he detrusor muscles.

8. Data indicate that MgATP2- activates P2X1 and P2X3 (show P2RX3 Proteins), but not P2X2 (show P2RX2 Proteins) and P2X4 (show P2RX4 Proteins) receptors.

9. These results suggest that conformational change in the P2X1 receptor is required for co-ordination of ATP action.

10. HSP90 (show HSP90 Proteins) inhibitors may be as effective as selective antagonists in regulating platelet P2X1 receptors, and their potential effects on hemostasis should be considered in clinical studies.

Mouse (Murine) Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1) interaction partners

1. Quite the reverse is seen in P2X1(-/-) mice, which had markedly lower cytokine levels and less coagulation activation compared to controls after exposure to uropathogenic Escherichia coli.

2. secretion of IL-22 (show IL22 Proteins) in the regenerating liver is modulated by the ATP receptor (show P2RX4 Proteins), P2X1

3. Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor (show TBXA2R Proteins), which partially requires the activation of P2X1R through an endothelium-dependent mechanism.

4. This study reveals a major role for the P2X1 receptor in LPS (show TLR4 Proteins)-induced lethal endotoxemia through its critical involvement in neutrophil emigration from venules.

5. NTPDase1 (show ENTPD1 Proteins) controls male fertility via the regulation of P2X1 activation.

6. The presence of the P2X1 receptor on both polymorphonuclear neutrophils and platelets is important for fibrin generation and thrombus formation in vivo.

7. Male contraception via simultaneous knockout of alpha1A (show CACNA1A Proteins)-adrenoceptors and P2X1-purinoceptors in mice.

8. loss of Dicer (show DICER1 Proteins) may impair the expression of miRNAs that are capable of targeting P2x mRNAs.

9. The activity of P2X2 (show P2RX2 Proteins)/3 receptors in nodose ganglion neurons is involved in the transmission of myocardial ischemic nociceptive signal.

10. The P2X receptor phenotype in megakaryocytes and (by inference) platelets is due to expression of homomeric P2X1 receptors.

Pig (Porcine) Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1) interaction partners

1. The authors show that porcine circovirus type 2 infection upregulated calcium/calmodulin-dependent protein kinase kinase-beta (show CAMKK2 Proteins) (CaMKKbeta) by increasing cytosolic Ca(2 (show CA2 Proteins)+) via inositol 1,4,5-trisphosphate receptor (IP3R (show ITPR1 Proteins)).