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anti-Rat (Rattus) ASXL2 Antibodies:
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after KIT and NRAS, ASXL2 is among the most frequently mutated genes in t(8;21)-positive acute myeloid leukemia (AML), occurring in almost 17% of the patients in the cohort; high incidence and the exclusivity of ASXL2 mutation in this AML subset implies its particular role as a potential co-operating event in leukemogenesis of t(8;21)-positive AML
ASXL2 and ZBTB7A mutations were frequently identified in Japanese AML patients with t(8;21), but not in those with inv(16). Further analysis is required to clarify the detailed biological mechanism of AE9a regulation of the cohesin complex.
Loss of ASXL2 expression is associated with tumorigenesis.
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.
Infrequent occurrence of TET1, TET3, and ASXL2 mutations in myelodysplastic/myeloproliferative neoplasms
Data indicate higher ASXL2 expression in ERalpha-positive patients, suggesting that ASXL2 could be a prognostic marker in breast cancer.
Mutation in ASXL2 is associated with core-binding factor acute myeloid leukemia.
ASXL2 mutation is associated with acute myeloid leukemia.
de novo truncating variants in ASXL2 underlie a neurodevelopmental syndrome with a clinically recognizable phenotype; this report expands the germline disorders that are linked to the ASXL genes
inactivation of the BAP1/ASXL2 axis might contribute to cancer development.
ASXL1, ASXL2 and ASXL3 are epigenetic scaffold proteins that are involved in the pathogenesis of non-cancerous diseases and cancers.[Review]
identify a high-frequency mutation in t(8;21)/RUNX1-RUNX1T1 acute myekoid leukemia (AML) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 mutations in this unique subset of AML
WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.
ASXL1 represses, whereas ASXL2 increases, the expression of adipogenic genes, most of which are PPARgamma targets
the apparent occurrence of an unusual TG 3' splice site in intron 2 is discussed
ASXL2 functions as a tumour suppressor to maintain normal Hematopoietic stem cell function.
ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis
Asxl2-/- neonates have patent ductus arteriosus and consequent lung hemorrhage and die soon after birth.
ASXL2 and WTIP are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP participate in regulation of retinoic acid signaling during heart development.
ASXL2 and PRC2 interact in the adult heart and co-localize to target promoters.
Chromatin factors like Asxl2 function in the adult heart to regulate cell type- and stage-specific patterns of gene expression.
the knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts.
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003
additional sex combs like 2
, additional sex combs like 2 (Drosophila)
, chimeric MOZ-ASXH2 fusion protein-like
, putative Polycomb group protein ASXL2-like
, additional sex combs-like protein 2
, polycomb group protein ASXH2
, putative Polycomb group protein ASXL2
, polycomb group protein ASXH2 homolog