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CaSR activation may play a fundamental role in selecting specific differentiation checkpoints of neurogenesis and osteogenesis
The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.
Calcium and the calcimimetic NPS (show NPS Proteins) R-467 reduce CaSR mRNA expression and stimulate cell growth/proliferation in equine size-sieved umbilical cord matrix mesenchymal stem cell.
GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR.
this study, demonstrates for the first time that calcium exerts an oncogenic action in the stomach through activation of CaSR and TRPV4 (show TRPV4 Proteins) channels. Both CaSR and TRPV4 (show TRPV4 Proteins) were involved in Ca2 (show CA2 Proteins)+-induced proliferation, migration, and invasion of gastric cancer cells through a Ca2 (show CA2 Proteins)+/AKT (show AKT1 Proteins)/beta-catenin (show CTNNB1 Proteins) relay, which occurred only in gastric cancer cells or normal cells overexpressing CaSR.
mutagenesis with a novel analytical approach and molecular modeling to develop an "enriched" picture of structure-function requirements for interaction between Ca(2 (show CA2 Proteins)+)o and allosteric modulators within the CaSR's 7 transmembrane (7TM) domain, is reported.
FLNA (show FLNA Proteins) is downregulated in parathyroid tumors and parallels the CASR expression levels. Loss of FLNA (show FLNA Proteins) reduces CASR mRNA and protein expression levels and the CASR-induced ERK (show EPHB2 Proteins) phosphorylation. FLNA (show FLNA Proteins) is involved in receptor expression, membrane localization and ERK (show EPHB2 Proteins) signaling activation of both 990R and 990G CASR variants.
A father and daughter with asymptomatic chronic hypocalcemia with low parathyroid hormone (show PTH Proteins) and inappropriate urinary calcium excretion had a missense mutation in exon 7: c.2621G>T (p.Cys874Phe).
These results support the emerging potential of CaSR as a therapeutic target in metastatic breast cancer whose pharmacological modulation would reduce IL-6 (show IL6 Proteins).
These structures reveal multiple binding sites for Ca(2 (show CA2 Proteins)+) and PO4(3-) ions. Both ions are crucial for structural integrity of the receptor. While Ca(2 (show CA2 Proteins)+) ions stabilize the active state, PO4(3-) ions reinforce the inactive conformation.
The endoplasmic reticulum-associated protein, OS-9 (show OS9 Proteins), behaves as a lectin in targeting the immature calcium-sensing receptor.
Glucose acts as a positive allosteric modulator of CaSR.
These studies indicate that the CaSR activation impairs glucose tolerance by a combination of alpha- and beta-cell defects and also influences pancreatic islet mass.
These findings indicate that cardiac function could be enhanced significantly by combination therapy with CaSR inhibition and ESC transplantation; the effect was better than ESC transplantation alone, and the mechanism might be associated with a reduction in cell apoptosis via the inhibition of the MAPK (show MAPK1 Proteins) pathway.
These findings suggest that trabecular bone formation can occur independently of the CaSR, and that the CaSR plays a collaborative role in the PTH (show PTH Proteins) anabolic effects on bone.
Vdr (show CYP27B1 Proteins) and Casr are required for beta-catenin (show CTNNB1 Proteins)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
we suggest that decreased Ca2 (show CA2 Proteins)+ levels and increased CaSR expression might be involved in increased insulin (show INS Proteins) secretion to compensate for insulin (show INS Proteins) resistance in aged mice.
physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR (show CFTR Proteins).
CaSR was localized in the basolateral membrane of basolateral membrane of type-B intercalated cell and was more expressed during alkali-loading
Demonstrate a role for CaSR in cardiovascular system and suggest physiologically relevant changes in extracellular Ca(2 (show CA2 Proteins)+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR.
Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.
fluoride might be able to affect calcium homeostasis by regulating PTH (show PTH Proteins), PTHrP, and CaSR
Heteromeric TRPV4 (show TRPV4 Proteins)-TRPC1 (show TRPC1 Proteins) channels mediate CaSR-induced vasorelaxation through NO production but not IKCa channel activation in rabbit mesenteric arteries.
Long-term activation of CaSR with cinacalcet disrupted the cadherin-catenin complex, induced cytoskeletal remodeling, actin fiber formation, and redistribution of CaSR to the nuclear area. These changes indicate a significant and complex role of CaSR in epithelial remodeling and barrier function of esophageal cells.
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
, vomeronasal receptor F-1
, calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, parathyroid gland calcium-sensing receptor
, extracellular calcium-sensing receptor-like
, extracellular calcium-sensing receptor
, parathyroid Ca(2+)-sensing receptor 1
, parathyroid cell calcium-sensing receptor
, parathyroid Cell calcium-sensing receptor
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism)
, Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
, G protein coupled receptor, family C, group 2, member A
, G protein-coupled receptor, family C, group 2, member A
, cation sensing receptor