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anti-Human Dopamine d2 Receptor Antibodies:
anti-Mouse (Murine) Dopamine d2 Receptor Antibodies:
anti-Rat (Rattus) Dopamine d2 Receptor Antibodies:
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Human Polyclonal Dopamine d2 Receptor Primary Antibody for IF (p), IHC (p) - ABIN730858
Xu, Wang, Chen, Chen, Li, Shao, Li, Lu, Zhou: Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. in Acta pharmacologica Sinica 2014
Show all 6 Pubmed References
Human Polyclonal Dopamine d2 Receptor Primary Antibody for IHC (p) - ABIN4305945
Srirajaskanthan, Watkins, Marelli, Khan, Caplin: Expression of somatostatin and dopamine 2 receptors in neuroendocrine tumours and the potential role for new biotherapies. in Neuroendocrinology 2009
Show all 2 Pubmed References
Human Monoclonal Dopamine d2 Receptor Primary Antibody for ELISA, WB - ABIN515070
Akimoto, Furuse: SCH23390, a dopamine D1 receptor antagonist, suppressed scratching behavior induced by compound 48/80 in mice. in European journal of pharmacology 2011
Human Polyclonal Dopamine d2 Receptor Primary Antibody for ELISA, WB - ABIN6261364
Liu, Geng, Zhang, Wang, Zhang, Duan, Zhang: Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway. in Marine drugs 2018
Bat Polyclonal Dopamine d2 Receptor Primary Antibody for IHC (p) - ABIN4305946
Saveanu, Sebag, Guillet, Archange, Essamet, Barlier, Palazzo, Taïeb: Targeting dopamine receptors subtype 2 (D2DR) in pheochromocytomas: head-to-head comparison between in vitro and in vivo findings. in The Journal of clinical endocrinology and metabolism 2013
Genetic variations in SLC6A3 and DRD2 may play an important role in pain expression among the elderly prior to orthopedic surgery
The findings of this study suggest that genetic subgrouping, in particular for DRD2, may be used to identify Parkinson's disease patient subgroups that are more dopamine responsive for gait function
Study results supported the hypothesis that DRD2 affected risperidone treatment. DRD1 had no significant effect on the response to risperidone, whereas DRD3 might be associated with an improvement in negative symptoms. [systematic review and meta-analysis]
The carriers of DRD2 risk haplotypes is at increased risk of dyskinesia.
Study found a 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated with heroin dependence in Han Chinese males. Study highlights the importance of considering haplotypes spanning adjacent genes and the cooperation and interaction of proximal variants or genes in genetic association studies.
Comparing the relative importance for the prediction of gIQ in an overlapping subsample, the results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission.
The more methamphetamine users chose to view methamphetamine images, the lower was their DRD2-type binding potential in the lateral orbitofrontal cortex, an important region in value-based choice.
the DRD2 Taq1A A1 allele magnifies the risk of Alzheimer's in aging African-Americans.
Results dhow that the presence of T allele (C/T, T/T) in c.957C > T SNP was associated with difficulty in impulse control, self-control of emotions, and conduct adjustment, which can contribute to improving the identification of mental and behavioral phenotypes associated with gene expression.
GxE interaction between DRD2, maternal parenting, and trajectories of depressive symptoms from early to mid-adolescence.
DRD2 TaqIA rs1822497 variation is an importance potential contributor to variation in maternal sensitivity and children's responses to such variation.
study assessed the effect of -141C insertion/deletion (Ins/Del) polymorphisms on DARPP-32 and CaN protein expression in the postmortem striatum of patients with schizophrenia and controls; expression levels of truncated DARPP and calcineurin were lower in Del allele carriers
Results provide first evidence of a link between genetic inter-individual variation in D2 receptor expression and goal-maintenance: carriers of two genes associated with lower striatal dopamine receptor density (C957T T+ and DRD2/ANKK1-TaqIA A+) perform at a higher level compared to non-carriers, and that this difference is specific to trials that require maintenance of active goal representations.
The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.
The prevalence of polymorphisms of the DRD3 gene and its association with the occurrence of metabolic syndrome in patients with refractory schizophrenia were evaluated
Significant DRD2xlead effects were found in the attention-deficit/hyperactivity disorder group, but not in the healthy control group in the frontal lobe. There was a significant negative correlation between the cortical thickness of the right superior frontal gyrus and inattention scores.
results reveal that the D2R can directly recruit GRK2 without G protein activation and that this mechanism may have relevance to achieving betaarr-biased signaling
The results from this study indicate that dopamine D2 receptor polymorphisms together with body mass index are important determinants to include in research that tests prediction error response of the brain.
DRD2 variant associated with task-specific anomaly in the directional flow of information or disconnection between the amygdala and the prefrontal cortex during emotional processing in persons with schizophrenia ant their siblings.
findings suggest that DRD2 levels might affect the progression of urothelial cell carcinoma (UCC), and the polymorphisms rs6277, rs1800497, and rs1799732 of DRD2 are probably associated with the susceptibility and clinicopathologic development of UCC in a Taiwanese population.
Studied a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to fescue toxicosis.
Drd2 signaling in the striatum alters the relationship between effort expenditure and extracellular dopamine.
Drd2 and Htr3a genes may play the key role in the synchronization of other genes of neurotransmitter systems in the ventral tegmental area of depressive male mice.
The reduction in goal-directed behavior is associated with dysfunction of D2R signaling via increased peripheral PYY.
The finding confirm the role of the dopamine D2 autoreceptors in reversal learning and suggest a broader involvement in behavioral inhibition mechanisms.
Results present evidence for the role of D2 dopamine receptors in structural alterations induced by the administration of the typical antipsychotic haloperidol and that chronic administration of clozapine has a limited influence on brain structure.
Impaired recruitment of dopamine neurons occurred during working memory in mice with striatal D2 receptor overexpression.
Findings show that loss-of-function of dopamine receptor type 2-expressing striatal medium spiny neurons (D2-MSNs) within ventrolateral striatum (VLS) is sufficient to reduce goal-directed behaviours.
Dopamine 2 receptor upregulation is associated with obesity.
D1/D2 medium spiny neurons in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease.
The present study evaluates the behavioral effects of pharmacological manipulation and genetic blockade of A2A R and D2 R within the frame of such a predominant striatal heteromeric population.
DRD2 in primary mesencephalic neurons had a significant regulative effect on the adipogenesis genes.
Dopamine D2 receptor deletion from parvalbumin interneurons in mouse causes an impaired inhibitory activity in the ventral hippocampus and a dysregulated dopaminergic system resulting in schizophrenia-like phenotypes.
boosting dopamine signaling in the striatum by acute cocaine administration reveals that absence of D2L, but not of D2S, strongly impairs the motor and cellular response to the drug, in a manner similar to the ablation of both isoforms. These results suggest that when the dopamine system is challenged, D2L signaling is required for the control of striatal circuits regulating motor activity.
These findings suggest the importance of Paraventricular Thalamus inhibition by D2Rs in modulating the sensitivity to cocaine, a finding that may have novel implications for human drug use.
This study explored the spatial distribution of D2 medium-sized spiny neurons across the rostral-caudal axis of the striatum using D2-eGFP double transgenic mice.
Pre- and postsynaptic colocalization of kappa opioid receptor and D2R supports a role for kappa opioid receptor potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens.
Study shows that social isolation to a series of schizophrenia-related deficits and that potential interactions among histidine triad nucleotide binding protein 1, NMDA receptor 1, and dopamine receptor 2 may underlie the behavioral deficits induced by social isolation.
These results are in support of intrastriatal connections of D2R(+)-MSNs (iMSNs) with dMSNs and indicate that D2R signaling in MSNs is critical for the function of intrastriatal circuits.
Activation of ventral tegmental area dopamine neurons promotes wakefulness via D2/D3 receptors.
Dopamine D2L isoform receptors and nucleus accumbens D2 receptor medium spiny neurons act to suppress the influence of previously correct behavioral strategies allowing transfer of behavioral control to new strategies.
Study shows that blocking dopamine D1Rs or stimulating dopamine D2Rs increased low-frequency theta and alpha oscillations known to be involved in learning and memory. In contrast, only D1R inhibition enhanced high-frequency beta oscillations, whereas only D2R stimulation increased gamma oscillations linked to top-down and bottom-up attentional processing.
findings highlight complementary modulatory contributions of dopamine d1 & d2 receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.
Extrastriatal D2, D3, and D4 receptor activation in external pallidal segments also influences direct pathway elements in the basal ganglia under normal and parkinsonian conditions.
Mapped associations occur between changes in D2 and D3 dopamine receptor occupancy and brain hemodynamics
These data provide evidence for a predisposition to self-administer cocaine based on dopamine D2 receptor availability, and demonstrate that the brain dopamine system responds rapidly following cocaine exposure.
The amount of dopamine d1 receptor, dopamine D2 receptor, and follicle stimulating hormone receptor mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.
The pig DRD2 gene was cloned, investigated its distribution in tissues and polymorphisms were identified.
The increase in NOS protein seen in both the endothelium and vascular smooth muscle in response to cerebral vasospasm is enhanced by dopamine in a D(2)R-dependent mechanism.
Damb receptor uniquely activates Gq to mobilize Ca(2+) signaling with greater efficiency and dopamine sensitivity
Findings suggest a role for dopamine D1-like receptor Dop1R2 in the repression of genes that coordinate metamorphosis.
Results suggest that the activation state of DAMB protein contributes to oxidative stress susceptibility in Drosophila and lead to a proposed model for paraquat neurotoxicity.
DD2R gene is expressed in the fat body, and its expression is higher in young females than in sexually mature females. The DD2R gene expression was not detected in ovarian follicular cells.
Dopamine D2 receptor play role in memory consolidation.
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia\; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
D(2) dopamine receptor
, dopamine D2 receptor
, dopamine receptor D2 isoform
, seven transmembrane helix receptor
, D2 dopamine receptor
, Dopamine D2 receptor
, dopamine receptor D2b
, dopamine D2 receptor 2
, D2 receptor
, dopamine receptor 2
, D(2) dopamine receptor A
, D2R 1
, dopamine receptor D2
, dopamine receptor 2 protein
, D[]-like receptor
, dopamine receptor in mushroom bodies
, dopamine-2 receptor