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Chicken Polyclonal GCG Primary Antibody for IEM, ICC - ABIN617889
Pak, Cha, Rajotte, McArthur, Yoon: Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody. in Diabetologia 1991
Show all 48 Pubmed References
Human Monoclonal GCG Primary Antibody for IHC (p) - ABIN3043073
Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct. in Lymphology 2011
Show all 6 Pubmed References
Human Monoclonal GCG Primary Antibody for CyTOF, FACS - ABIN4900763
Kornete, Beauchemin, Polychronakos, Piccirillo: Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. in Autoimmunity 2013
Show all 3 Pubmed References
Human Monoclonal GCG Primary Antibody for ELISA, WB - ABIN966191
Geliebter, Hashim, Gluck: Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED). in Physiology & behavior 2008
Show all 2 Pubmed References
Human Polyclonal GCG Primary Antibody for ICC, IF - ABIN451504
Rovira, Scott, Liss, Jensen, Thayer, Leach: Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Polyclonal GCG Primary Antibody for ELISA, IF - ABIN2473808
Koistinaho, Hatanpää, Hervonen: Human paraganglion cells differentiate into adrenergic neurons in culture. in Experimental neurology 1990
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Human Monoclonal GCG Primary Antibody for ELISA, WB - ABIN969171
Arnés, González, Tornero-Esteban, Sancho, Acitores, Valverde, Delgado, Villanueva-Peñacarrillo: Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle. in International journal of molecular medicine 2008
Human Monoclonal GCG Primary Antibody for IHC, ELISA - ABIN1585964
Hayes, Zhang, Becker, Haldeman, Stephens, Arlotto, Moss, Newgard, Hohmeier: A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. in Molecular and cellular biology 2017
Human Monoclonal GCG Primary Antibody for IF, IHC (p) - ABIN111416
Eissele, Göke, Willemer, Harthus, Vermeer, Arnold, Göke: Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. in European journal of clinical investigation 1992
Show all 2 Pubmed References
Human Polyclonal GCG Primary Antibody for IF (p), IHC (p) - ABIN704246
Sun, Nie, Wang, Yang, Meng, Xiao, Xiang, Li, Fu, Wang: Factors that Affect Pancreatic Islet Cell Autophagy in Adult Rats: Evaluation of a Calorie-Restricted Diet and a High-Fat Diet. in PLoS ONE 2016
Glucagon-like peptide (GLP-2) stimulates cancer myofibroblast proliferation, migration and invasion; GLP-2 acts indirectly on epithelial cells partly via increased Insulin (show INS Antibodies)-like growth factor (IGF) expression in myofibroblasts.
Describe model, in which the release of GIP (show GIP Antibodies)/GLP-1 is stimulated by glucose in the proximal small intestine, and no differences in the secretion dynamics between healthy individuals and patients with T2D are identified after taking differences in glucose profiles into account.
the solvent exposure of the two Phe sites along the glucagon sequence was determined, showing that 4F-Phe6 was fully solvent exposed and 4F-Phe22 was only partially exposed
Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 = glucagon-like peptide 1)
GLP-2 could be considered an hormone causing positive energy balance, which, however has the role to mitigate the metabolic dysfunctions associated with hyper-adiposity. [review]
Studies indicate that nutrient-induced glucagonlike peptide-1 (GLP-1) response was one of the best predictors of type 2 diabetes mellitus (T2DM) remission after Roux-en-Y-gastric-bypass (RYGB).
Insulin (show INS Antibodies) resistance in non-diabetic individuals is associated with raised fasting GLP-1 levels but reduced GLP-1 responses to meal stimulation.
we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor (show EGFR Antibodies) and activation of Foxo1 (show FOXO1 Antibodies), resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase (show AMY Antibodies) and lipase (show LIPG Antibodies) levels in subjects treated with GLP-1 receptor (show GLP1R Antibodies) agonists reflect adaptive growth rather than early-stage pancreatitis.
Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Data suggest early peaks in glucagon-like peptide-1 and glucagon secretion/blood level together trigger exaggerated insulinotropic response (high insulin (show INS Antibodies) secretion/level) to eating and consequent hypoglycaemia in patients with postprandial hypoglycaemia as a postoperative complication following Roux-en-Y gastric bypass for obesity complicated by type 2 diabetes; this retrospective cohort study was conducted in London.
in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 (show FFAR1 Antibodies) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
Enteric GLP-1 activates NO production by enteric neurons that is impaired in type 2 diabetes. Gut (show GUSB Antibodies) microbiota dysbiosis induces enteric neuropathy. Gut (show GUSB Antibodies) microbiota dysbiosis is responsible for the GLP-1 resistance.
of glucagon-like peptide-1 in vagotomized mice may prevent VLDL overproduction and insulin (show INS Antibodies) resistance induced by high-fat diet.
beta-cell function, plasma active GLP-1 levels, the GLP-1R (show GLP1R Antibodies) pathway in beta cells and L cell differentiation, were investigated.
CCK (show CCK Antibodies)/GLP-1 play contributory roles in anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol.
The role of syntaxin 1A (show STX1A Antibodies) in GLP1 release from intestinal cells as a response to external stimuli is reported.
GCG neurons likely stimulate separate populations of downstream cells to produce a change in food intake and glucose homeostasis and that these effects depend on the metabolic state of the animal.
Together, our data indicate effects of AgoPAMs that go beyond glucose lowering previously observed with GPR40 (show FFAR1 Antibodies) partial agonist treatment with additional potential for weight loss.
pancreatic reactivation of Gcg fully restored the effect of exendin-[9-39] to impair both oral and intraperitoneal glucose tolerance.
these findings identify distinct roles for DPP4 (show DPP4 Antibodies) in the endothelial cell versus the bone marrow compartment for selective incretin degradation and DPP4 (show DPP4 Antibodies) inhibition-mediated glucoregulation.
data demonstrate that cattle express proglucagon and glucagon-like peptide 2 receptor (show GLP2R Antibodies) mRNA primarily in small intestinal and colon tissues and increased nutrient intake increases ileal proglucagon mRNA and plasma glucagon-like peptide 2
Data suggest that casein, safflower oil, sucrose, and sweetening agent rebaudioside A stimulate GLP1 release/secretion from enteroendocrine cells. (GLP1 = glucagon-like peptide 1, a peptide fragment derived from proglucagon)
The patterns of colocalization of the K cell marker, glucagon-like insulinotropic peptide, and L cell markers, glucagon like peptide-1 and peptide YY, in enteroendocrine cells of the small intestine and colon of mouse and pig, were investigated.
The findings indicate that the brainstem preproglucagon neuronal system is highly conserved between rat and non-human primate
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I
, glucagon-like peptide-1
, preproglucagon B
, glucagon preproprotein
, preproglucagon A
, glucagon I
, proglucagon I