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Chicken Polyclonal GCG Primary Antibody for IEM, ICC - ABIN617889
Pak, Cha, Rajotte, McArthur, Yoon: Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody. in Diabetologia 1991
Show all 48 Pubmed References
Human Monoclonal GCG Primary Antibody for IHC (p) - ABIN3043073
Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct. in Lymphology 2011
Show all 6 Pubmed References
Human Monoclonal GCG Primary Antibody for CyTOF, FACS - ABIN4900763
Kornete, Beauchemin, Polychronakos, Piccirillo: Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. in Autoimmunity 2013
Show all 3 Pubmed References
Human Polyclonal GCG Primary Antibody for ELISA, IF - ABIN2473808
Koistinaho, Hatanpää, Hervonen: Human paraganglion cells differentiate into adrenergic neurons in culture. in Experimental neurology 1990
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Human Monoclonal GCG Primary Antibody for ELISA, WB - ABIN966191
Geliebter, Hashim, Gluck: Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED). in Physiology & behavior 2008
Show all 2 Pubmed References
Human Polyclonal GCG Primary Antibody for ELISA - ABIN2473805
Woods, Lutz, Geary, Langhans: Pancreatic signals controlling food intake; insulin, glucagon and amylin. in Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006
Human Polyclonal GCG Primary Antibody for IF (p), IHC (p) - ABIN704246
Sun, Nie, Wang, Yang, Meng, Xiao, Xiang, Li, Fu, Wang: Factors that Affect Pancreatic Islet Cell Autophagy in Adult Rats: Evaluation of a Calorie-Restricted Diet and a High-Fat Diet. in PLoS ONE 2016
Human Monoclonal GCG Primary Antibody for ELISA, WB - ABIN969171
Arnés, González, Tornero-Esteban, Sancho, Acitores, Valverde, Delgado, Villanueva-Peñacarrillo: Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle. in International journal of molecular medicine 2008
Human Polyclonal GCG Primary Antibody for RIA - ABIN2473807
Figueroa, Hess, Ky, Brown, Sandig, Hermanowski-Vosatka, Twells, Todd, Austin: Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000
Human Monoclonal GCG Primary Antibody for IF, IHC (p) - ABIN111416
Eissele, Göke, Willemer, Harthus, Vermeer, Arnold, Göke: Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. in European journal of clinical investigation 1992
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RYGB increased circulating bile acids, ileal Takeda G protein-coupled receptor 5 (show XCR1 Antibodies) (TGR5 (show GPBAR1 Antibodies)) and mTORC1 signaling activity, as well as GLP-1 production in both mice and human subjects. Inhibition of ileal mTORC1 signaling by rapamycin significantly attenuated the stimulation of bile acid secretion, TGR5 (show GPBAR1 Antibodies) expression and GLP-1 synthesis induced by RYGB in lean and diet-induced obese mice.
Glucagon role in the pathophysiology of type 2 diabetes.[review]
This review summarizes the current knowledge regarding the role of GLP-1 in the protection against oxidative damage and the activation of the Nrf2 (show GABPA Antibodies) signaling pathway. [review]
Study concludes that in healthy subjects, glucagon-like peptide-1 (GLP-1) increases cardiac output acutely due to a GLP-1-induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.
Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass.
The results demonstrate that glucagon-like peptide-1 and insulin (show INS Antibodies) synergistically and additively activate vagal afferent neurons.
DPP-4 (show DPP4 Antibodies) activity and GLP (show RCBTB1 Antibodies)-1total levels were higher in patients with microvascular complications associated with T2DM. Contrary to expectations, no negative correlation was seen between GLP-1 and DDP (show TIMM8A Antibodies)-4 levels. This result suggests the possible inefficacy of DDP (show TIMM8A Antibodies)-4 activity as a marker to predict in vivo degradation of endogenous GLP-1.
Data suggest that cAMP acts as amplifier of insulin (show INS Antibodies) secretion triggered by Ca2 (show CA2 Antibodies)+ elevation in beta-cells; both messengers are also positive modulators of glucagon release from alpha-cells, but in this case cAMP signaling may be the important regulator and Ca2 (show CA2 Antibodies)+ signaling has a more permissive role. [REVIEW]
This study provides evidence that, in HepG2 cells, GLP-1 may affect cholesterol homeostasis by regulating the expression of miR (show MLXIP Antibodies)-758 and ABCA1 (show ABCA1 Antibodies).
This study reports the transition dipole strengths and frequencies of the amyloid beta-sheet amide I mode for the aggregated proteins amyloid-beta1-40, calcitonin (show CALCA Antibodies), alpha-synuclein, and glucagon.
the results of the present study indicated that GLP1 may be a promising target for the development of novel therapeutic strategies for HGinduced nephropathy, and may function through the activation of SIRT1 (show SIRT1 Antibodies)
this study, we investigated whether glucagon and glucagon-like peptide-1 (GLP-1), hormones produced by alpha cells, contribute to insulin (show INS Antibodies) secretion in INS-1 cells, a beta (show SUCLA2 Antibodies) cell line. Co-treatment with glucagon and exendin-4 (Ex-4), a GLP-1 receptor (show GLP1R Antibodies) agonist, additively increased glucose-stimulated insulin (show INS Antibodies) secretion in INS-1 cells
FXR (show NR1H4 Antibodies) exerts its function in L cells through interacting with CREB (show CREB1 Antibodies), a crucial transcriptional regulator of cAMP-CREB (show CREB1 Antibodies) signaling pathway, to inhibit its transcriptional activity. Targeting FXR (show NR1H4 Antibodies) to rescue GLP-1 secretion may be a promising strategy for type II diabetes.
results show that glucagon controls gene expression and metabolic zonation in the liver through a counterplay with the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
Data (including data from studies using transgenic and knockout mice) suggest that Glp1/Glp1r (show GLP1R Antibodies) signaling in insulin (show INS Antibodies)-secreting cells plays important role in development of glucose intolerance in obesity; however, Glp1r (show GLP1R Antibodies) is not required in insulin (show INS Antibodies)-secreting cells for improvement in glucose intolerance after weight loss due to bariatric surgery (here, vertical sleeve gastrectomy).
Chronic stress accelerates DPP4-mediated GLP-1 degradation and alters plasma adiponectin, accelerating vascular senescence and impairing ischemia-induced neovascularization.
Data suggest that metabolism of glutamine (show GFPT1 Antibodies) and related analogs by Gdh (show UGDH Antibodies) in intestinal L-cells explains why Glp1 secretion, but not that of insulin (show INS Antibodies) by pancreatic beta-cells, is activated by these secretagogues. (Gdh (show UGDH Antibodies) = glutamate (show GRIN1 Antibodies) dehydrogenase; Glp1 = glucagon-like peptide 1)
Glucokinase (show GCK Antibodies) governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 (show FFAR1 Antibodies) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
Enteric GLP-1 activates NO production by enteric neurons that is impaired in type 2 diabetes. Gut (show GUSB Antibodies) microbiota dysbiosis induces enteric neuropathy. Gut (show GUSB Antibodies) microbiota dysbiosis is responsible for the GLP-1 resistance.
data demonstrate that cattle express proglucagon and glucagon-like peptide 2 receptor (show GLP2R Antibodies) mRNA primarily in small intestinal and colon tissues and increased nutrient intake increases ileal proglucagon mRNA and plasma glucagon-like peptide 2
Data suggest that casein, safflower oil, sucrose, and sweetening agent rebaudioside A stimulate GLP1 release/secretion from enteroendocrine cells. (GLP1 = glucagon-like peptide 1, a peptide fragment derived from proglucagon)
The patterns of colocalization of the K cell marker, glucagon-like insulinotropic peptide, and L cell markers, glucagon like peptide-1 and peptide YY, in enteroendocrine cells of the small intestine and colon of mouse and pig, were investigated.
The findings indicate that the brainstem preproglucagon neuronal system is highly conserved between rat and non-human primate
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I
, glucagon-like peptide-1
, preproglucagon B
, glucagon preproprotein
, preproglucagon A
, glucagon I
, proglucagon I