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we conclude that TMPRSS11D could play a role in non-small cell lung cancer development and progression
HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas
H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin (show HA Proteins) are activated by matriptase (show ST14 Proteins) in addition to HAT (show MGEA5 Proteins) and TMPRSS2 (show TMPRSS2 Proteins) and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity.
TMPRSS2 (show TMPRSS2 Proteins) and HAT (show MGEA5 Proteins) are expressed by important influenza and SARS (show SARS Proteins)-coronavirus target cells and could thus support viral spread in the human host.
results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAT)
HAT cleaves proMSP at the physiological activation site
Human HAT cleaved severe acute respiratory syndrome coronavirus spike protein at R667, as determined by mutagenesis and mass spectrometry.
HAT (show MGEA5 Proteins) regulates cellular functions of human bronchial epithelial cells via activation of protease-activated receptor-2 (show F2RL1 Proteins).
HAT (show MGEA5 Proteins) might promote PAR-2 (show F2RL1 Proteins)-mediated IL-8 (show IL8 Proteins) production to accumulate inflammatory cells in the epidermal layer of psoriasis.
results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts
A comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, TMPRSS11A and HAT, was performed.
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
airway trypsin like protease
, airway trypsin-like protease
, transmembrane protease serine 11D
, adrenal secretory serine protease
, airway spesific trypsin-like protease
, transmembrane serine protease 11D