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Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK (show MAPK1 Proteins) signaling pathway in pluripotent cells
The data suggest that Spred1 negatively regulates group 2 innate lymphoid cell development and functions through the suppression of the Ras-ERK (show EPHB2 Proteins) pathway.
Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1).
show that neurofibromin (show NF1 Proteins), the NF1 (show NF1 Proteins) gene product, is a Spred1-interacting protein that is necessary for Spred1's inhibitory function
The results suggest that Spred1 negatively regulates mast cell activation, which is modulated by miR126.
SPRED1 is a likely substrate of SHP2 (show PTPN11 Proteins), whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK (show EPHB2 Proteins) pathway.
Data show that both SPRED1 and SPRED2 (show SPRED2 Proteins) inhibit the ability of DYRK1A (show DYRK1A Proteins) to phosphorylate its substrates.
These data suggest that Spreds are key regulators of RhoA (show RHOA Proteins)-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.
Spred-1 and Spred-2 (show SPRED2 Proteins) were found to be expressed predominantly in brain
The EVH1 domain of Spred1 binds to the noncatalytic portion of the GAP-related domain of neurofibromin (show NF1 Proteins).
Results provide genetic evidence that miR (show MLXIP Proteins)-126, through its target gene Spred-1, plays a critical role in the development of retinal vascular layers.
In one case we identified a nonsense mutation c.46C>T (p.Arg16*) in exon 2 of SPRED1 gene, confirming diagnosis of Legius syndrome. This mutation was reported previously.
PURA (show PURA Proteins) may be a potential target of miR (show MLXIP Proteins)-144 and observed downregulation of PURA (show PURA Proteins) may be caused by increased expression of miR (show MLXIP Proteins)-144. The other predicted target of miR (show MLXIP Proteins)-144 SPRED1, was found to be downregulated in 69 per cent EC tissues as compared to matched distant non-malignant tissues.
Data suggest SPRED1 EVH1 domain interacts with NF1 (show NF1 Proteins) GRD domain [N-term. 16AA/C-term. 20AA of GTPase-activating protein (show RASA1 Proteins)-related domain]; SPRED1 EVH1 and NF1 (show NF1 Proteins) GRD mutations observed in Legius syndrome reduce binding affinity between EVH1/GRD domains.
SPRED1 decreased expression correlated with genetic features of AML (show RUNX1 Proteins). Our study reveals a new mechanism which contributes to deregulate RAS MAPK (show MAPK1 Proteins) pathway in the vast majority of paediatric AMLs
Antisense-mediated knockdown (anti-miR (show MLXIP Proteins)) revealed that miR (show MLXIP Proteins)-206/21 coordinately promote RAS-ERK (show EPHB2 Proteins) signaling and the corresponding cell phenotypes by inhibiting translation of the pathway suppressors RASA1 (show RASA1 Proteins) and SPRED1.
SPRED1 seems to play an important role in recruiting neurofibromin (show NF1 Proteins) to the plasma membrane. (Review)
Older age and deletions of IKZF1 (show IKZF1 Proteins) and SPRED1 were also associated with poor overall survival of pediatric B-cell precursor acute lymphoblastic leukemia.
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
sprouty-related, EVH1 domain-containing protein 1
, sprouty-related protein with EVH-1 domain 1
, sprouty-related, EVH1 domain containing 1
, sprouty-related, EVH1 domain-containing protein 1-like
, sprouty-related protein 1 with EVH-1 domain
, suppressor of Ras/MAPK activation
, sprouty protein with EVH-1 domain 1, related sequence